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学科主题: 临床医学
题名:
The link between mold sensitivity and asthma severity in a cohort of northern Chinese patients
作者: Ma, Yanliang1; Tian, Guizhen2; Tang, Fei1; Yu, Bing1; Chen, Yanwen1; Cui, Yueli1; He, Quanying1; Gao, Zhancheng1
关键词: Asthma ; sensitization ; severity ; molds ; allergy ; lung function
刊名: JOURNAL OF THORACIC DISEASE
发表日期: 2015-04-01
DOI: 10.3978/j.issn.2072-1439.2015.01.04
卷: 7, 期:4, 页:585-590
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Respiratory System
研究领域[WOS]: Respiratory System
关键词[WOS]: SENSITIZATION ; PREVALENCE ; RISK ; RHINITIS ; FUNGI
英文摘要:

Background: Mold sensitivity in asthmatic patients has recently attracted clinical interest; however the links between mold sensitivity and asthma severity in the Chinese population have been poorly characterized. In this study, we assess the relationship between asthma severity and airborne mold sensitivity in a cohort of northern Chinese patients.

Methods: Ninety-three non-smoking adult outpatients with asthma completed a questionnaire and underwent skin prick testing with five aeroallergens. For all patients, eosinophil cell counts, total serum IgE (sIgE) levels, and pulmonary function were measured. An asthma severity score was calculated based on the patient′s forced expiratory volume in one second (FEV1), number of asthma attacks, number of hospital admissions, and use of inhaled or oral corticosteroids in the past year.

Results: Ninety-three patients were divided into three groups based on the results of their allergy tests: negative results for all tested allergens (group A, n=32); positive reactions to aeroallergens including mold antigens (group B, n=41); and positive reactions to aeroallergens other than molds (group C, n=20). Patients in group B had a lower FEV1 (74.46%+/-23.09% predicted) compared with group A (85.52%+/-19.53%, P=0.023). Patients in both group B and C had elevated absolute eosinophil count (AEC) (group A: 3.12%+/-2.71%, group B: 5.41%+/-2.85%, group C: 6.1%+/-4.49%; group A vs. group B, P=0.008; group A vs. group C, P=0.002), and total sIgE values (group A: 117.36+/-144.90 IU/mL, group B: 195.86+/-155.87 IU/mL, group C: 253.31+/-152.41 IU/mL; group A vs. group B, P=0.031; group A vs. group C, P=0.002) compared with patients in group A. Asthma severity scores were higher in patients in group B compared to patients in group C (7 vs. 5.5, P<0.05). Patients allergic to molds were more likely to have severe asthma [odds ratio 3.636, 95% confidence interval (CI): 1.394 to 9.484; for severe versus mild asthma, P<0.05]. There was no association between asthma severity and sensitisation to house mites or weeds.

Conclusions: Mold sensitivity is positively correlated with asthma severity in our cohort of northern Chinese patients.

语种: 英语
所属项目编号: RDC2009-16
项目资助者: Research and Development funds of Peking University People&prime ; s Hospital
WOS记录号: WOS:000355276400020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65601
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100044, Peoples R China
2.Peoples Liberat Army, Hosp 263, Dept Resp & Crit Care Med, Beijing 101100, Peoples R China

Recommended Citation:
Ma, Yanliang,Tian, Guizhen,Tang, Fei,et al. The link between mold sensitivity and asthma severity in a cohort of northern Chinese patients[J]. JOURNAL OF THORACIC DISEASE,2015,7(4):585-590.
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