IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
The link between mold sensitivity and asthma severity in a cohort of northern Chinese patients
Ma, Yanliang1; Tian, Guizhen2; Tang, Fei1; Yu, Bing1; Chen, Yanwen1; Cui, Yueli1; He, Quanying1; Gao, Zhancheng1
关键词Asthma sensitization severity molds allergy lung function
刊名JOURNAL OF THORACIC DISEASE
2015-04-01
DOI10.3978/j.issn.2072-1439.2015.01.04
7期:4页:585-590
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Respiratory System
资助者Research and Development funds of Peking University People&prime ; s Hospital ; Research and Development funds of Peking University People&prime ; s Hospital
研究领域[WOS]Respiratory System
关键词[WOS]SENSITIZATION ; PREVALENCE ; RISK ; RHINITIS ; FUNGI
英文摘要

Background: Mold sensitivity in asthmatic patients has recently attracted clinical interest; however the links between mold sensitivity and asthma severity in the Chinese population have been poorly characterized. In this study, we assess the relationship between asthma severity and airborne mold sensitivity in a cohort of northern Chinese patients.

Methods: Ninety-three non-smoking adult outpatients with asthma completed a questionnaire and underwent skin prick testing with five aeroallergens. For all patients, eosinophil cell counts, total serum IgE (sIgE) levels, and pulmonary function were measured. An asthma severity score was calculated based on the patient′s forced expiratory volume in one second (FEV1), number of asthma attacks, number of hospital admissions, and use of inhaled or oral corticosteroids in the past year.

Results: Ninety-three patients were divided into three groups based on the results of their allergy tests: negative results for all tested allergens (group A, n=32); positive reactions to aeroallergens including mold antigens (group B, n=41); and positive reactions to aeroallergens other than molds (group C, n=20). Patients in group B had a lower FEV1 (74.46%+/-23.09% predicted) compared with group A (85.52%+/-19.53%, P=0.023). Patients in both group B and C had elevated absolute eosinophil count (AEC) (group A: 3.12%+/-2.71%, group B: 5.41%+/-2.85%, group C: 6.1%+/-4.49%; group A vs. group B, P=0.008; group A vs. group C, P=0.002), and total sIgE values (group A: 117.36+/-144.90 IU/mL, group B: 195.86+/-155.87 IU/mL, group C: 253.31+/-152.41 IU/mL; group A vs. group B, P=0.031; group A vs. group C, P=0.002) compared with patients in group A. Asthma severity scores were higher in patients in group B compared to patients in group C (7 vs. 5.5, P<0.05). Patients allergic to molds were more likely to have severe asthma [odds ratio 3.636, 95% confidence interval (CI): 1.394 to 9.484; for severe versus mild asthma, P<0.05]. There was no association between asthma severity and sensitisation to house mites or weeds.

Conclusions: Mold sensitivity is positively correlated with asthma severity in our cohort of northern Chinese patients.

语种英语
所属项目编号RDC2009-16
资助者Research and Development funds of Peking University People&prime ; s Hospital ; Research and Development funds of Peking University People&prime ; s Hospital
WOS记录号WOS:000355276400020
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65601
Collection北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100044, Peoples R China
2.Peoples Liberat Army, Hosp 263, Dept Resp & Crit Care Med, Beijing 101100, Peoples R China
Recommended Citation
GB/T 7714
Ma, Yanliang,Tian, Guizhen,Tang, Fei,et al. The link between mold sensitivity and asthma severity in a cohort of northern Chinese patients[J]. JOURNAL OF THORACIC DISEASE,2015,7(4):585-590.
APA Ma, Yanliang.,Tian, Guizhen.,Tang, Fei.,Yu, Bing.,Chen, Yanwen.,...&Gao, Zhancheng.(2015).The link between mold sensitivity and asthma severity in a cohort of northern Chinese patients.JOURNAL OF THORACIC DISEASE,7(4),585-590.
MLA Ma, Yanliang,et al."The link between mold sensitivity and asthma severity in a cohort of northern Chinese patients".JOURNAL OF THORACIC DISEASE 7.4(2015):585-590.
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