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学科主题: 临床医学
题名:
Serum complement factor H is associated with clinical and pathological activities of patients with lupus nephritis
作者: Wang, Feng-mei1,2,3,4; Yu, Feng1,2,3,4; Tan, Ying1,2,3,4; Song, Di1,2,3,4; Zhao, Ming-hui1,2,3,4
关键词: SLE ; lupus nephritis ; complement factor H
刊名: RHEUMATOLOGY
发表日期: 2012-12-01
DOI: 10.1093/rheumatology/kes218
卷: 51, 期:12, 页:2269-2277
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: HEMOLYTIC-UREMIC SYNDROME ; CLASS-IV-G ; DISEASE-ACTIVITY ; ACTIVATION PRODUCTS ; ITALIAN FAMILY ; FACTOR-B ; ERYTHEMATOSUS ; PATHOGENESIS ; DEFICIENCY ; GLOMERULONEPHRITIS
英文摘要:

Objective. The aim of this study was to investigate serum complement factor H (CFH) and its associations with clinical and pathological features in patients with LN.

Methods. Serum CFH was detected in 241 LN patients, 38 active and 11 inactive patients with SLE without clinical evidence of renal involvement and 51 normal controls. Serum CFH autoantibodies and CFH Tyr402His were screened in the 241 LN patients. CFH deposition in kidneys was detected in some patients.

Results. Serum CFH levels in patients with LN at active phase were significantly lower than in 38 SLE patients or in normal controls. No serum anti-CFH autoantibodies were detected in patients with LN, and there was no significant difference in CFH Tyr402His distribution between patients with LN and normal controls. Glomerular expression of CFH was stronger than in normal controls. Serum CFH levels were mildly negatively associated with SLEDAI scores (r = -0.204, P = 0.001) and positively associated with serum C3 (r = 0.367, P < 0.001) and haemoglobulin levels (r = 0.193, P = 0.003). Patients with LN class III, subclass IV-S and those with thrombotic microangiopathy had the lowest serum CFH.

Conclusion. Serum CFH levels were associated with disease activity of LN.

语种: 英语
所属项目编号: 2012CB517702 ; 81021004 ; 81100497 ; 7102150
项目资助者: Chinese 973 project ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000311901700060
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65607
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
4.Minist Educ China, Key Lab Chron Kidney Dis Prevent & Treatment, Beijing, Peoples R China

Recommended Citation:
Wang, Feng-mei,Yu, Feng,Tan, Ying,et al. Serum complement factor H is associated with clinical and pathological activities of patients with lupus nephritis[J]. RHEUMATOLOGY,2012,51(12):2269-2277.
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