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学科主题: 精神卫生
题名:
Heritability and familiality of neurological soft signs: evidence from healthy twins, patients with schizophrenia and non-psychotic first-degree relatives
作者: Xu, T.1; Wang, Y.1; Li, Z.1,2; Huang, J.1; Lui, S. S. Y.1,3; Tan, S. -P.4; Yu, X.5,6,7; Cheung, E. F. C.3; He, M. -G.8,9; Ott, J.10; Gur, R. E.11,12; Gur, R. C.11,12; Chan, R. C. K.1
关键词: Endophenotypes ; familiality ; healthy twins ; heritability ; neurological soft signs
刊名: PSYCHOLOGICAL MEDICINE
发表日期: 2016
DOI: 10.1017/S0033291715001580
卷: 46, 期:1, 页:117-123
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Social Sciences ; Science & Technology
类目[WOS]: Psychology, Clinical ; Psychiatry ; Psychology
研究领域[WOS]: Psychology ; Psychiatry
关键词[WOS]: MINOR PHYSICAL ANOMALIES ; ABNORMALITIES ; ENDOPHENOTYPES ; DISORDERS ; METAANALYSIS ; INVENTORY ; FEATURES
英文摘要:

Background. Neurological soft signs (NSS) have long been considered potential endophenotypes for schizophrenia. However, few studies have investigated the heritability and familiality of NSS. The present study examined the heritability and familiality of NSS in healthy twins and patient-relative pairs.

Method. The abridged version of the Cambridge Neurological Inventory was administered to 267 pairs of monozygotic twins, 124 pairs of dizygotic twins, and 75 pairs of patients with schizophrenia and their non-psychotic first-degree relatives.

Results. NSS were found to have moderate but significant heritability in the healthy twin sample. Moreover, patients with schizophrenia correlated closely with their first-degree relatives on NSS.

Conclusions. Taken together, the findings provide evidence on the heritability and familiality of NSS in the Han Chinese population.

语种: 英语
所属项目编号: 81088001 ; KSCX2-EW-J-8 ; Y2CX131003 ; Z151100000315020
项目资助者: Outstanding Young Investigator Award of the National Science Fund China ; Key Laboratory of Mental Health of the Chinese Academy of Sciences ; Knowledge Innovation Project of the Chinese Academy of Sciences ; CAS/SAFEA International Partnership Programme for Creative Research Team ; Beijing Training Project For The Leading Talents in S T
WOS记录号: WOS:000366651100010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65608
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Beijing Huilongguan Hosp, Beijing, Peoples R China
2.Peking Univ, Hosp 6, Beijing 100871, Peoples R China
3.Peking Univ Mental Hlth, Beijing, Peoples R China
4.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
5.Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
7.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
8.Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510275, Guangdong, Peoples R China
9.Univ Melbourne, Ctr Eye Res Australia, Melbourne, Vic 3010, Australia
10.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Stat Genet Lab, Beijing 100101, Peoples R China
11.Univ Penn, Dept Psychiat, Perelman Sch Med, Philadelphia, PA 19104 USA
12.Philadelphia Vet Adm Med Ctr, Philadelphia, PA USA

Recommended Citation:
Xu, T.,Wang, Y.,Li, Z.,et al. Heritability and familiality of neurological soft signs: evidence from healthy twins, patients with schizophrenia and non-psychotic first-degree relatives[J]. PSYCHOLOGICAL MEDICINE,2016,46(1):117-123.
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