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学科主题: 药学
题名:
Cholestane-3 beta,5 alpha,6 beta-triol inhibits osteoblastic differentiation and promotes apoptosis of rat bone marrow stromal cells
作者: Liu, HM; Yuan, L; Xu, SJ; Wang, K; Zhang, TL
关键词: cholestane-3 beta,5 alpha,6 beta-triol ; marrow stromal cells ; differentiation ; apoptosis ; intracellular Ca2+ ; reactive oxygen species
刊名: JOURNAL OF CELLULAR BIOCHEMISTRY
发表日期: 2005-09-01
DOI: 10.1002/jcb.20510
卷: 96, 期:1, 页:198-208
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: LOW-DENSITY-LIPOPROTEIN ; SMOOTH-MUSCLE-CELLS ; SPONTANEOUS CALCIUM TRANSIENTS ; MESENCHYMAL STEM-CELLS ; ALKALINE-PHOSPHATASE ; NEURONAL DIFFERENTIATION ; CARDIOVASCULAR-DISEASE ; ENDOTHELIAL-CELLS ; MATRIX VESICLES ; CALCIFICATION
英文摘要:

Converging lines of evidence suggest that oxidized lipids, long recognized as a risk factor in atherogenesis, also contribute to osteoporosis, but the underlying mechanism is not understood in detail. The effect of atherogenesis related factors including oxysterols on the differentiation and survival of marrow stromal cells (MSCs) would be very important in understanding the link between atherosclerosis and osteoporosis. In the present study, the effect of oxysterol cholestane-3 beta,5 alpha,6 beta-triol (Triol) on osteoblastic differentiation and apoptosis of primary rat bone MSCs as well as the related mechanisms were studied. Triol inhibited MSCs osteoblastic differentiation as demonstrated by inhibition of alkaline phosphatase activity, osteocalcin secretion, and matrix mineralization. In the other aspect, Triol promoted MSCs apoptosis, as characterized by condensed or fragmented nuclei as well as active externalization of phosphatidyl serine to the cell surface. In addition, Triol was found to induce increases of intracellularCa(2+) and Ca2+-dependent reactive oxygen species generation in MSCs. These effects were involved in the action of Triol on apoptosis, but not on osteoblastic differentiation of MSCs. These results suggested that Triol might contribute to the decreased bone formation by inhibition of osteoblastic differentiation and promotion of apoptosis of MSCs, providing insights about common factors underlying the pathogenesis of atherosclerosis and osteoporosis.

语种: 英语
WOS记录号: WOS:000231739500020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65611
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Chem Biol, Beijing 100083, Peoples R China
2.Huazhong Univ Sci & Technol, Dept Chem, Wuhan 430074, Hubei, Peoples R China
3.Peking Univ, Med & Healthy Anal Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Liu, HM,Yuan, L,Xu, SJ,et al. Cholestane-3 beta,5 alpha,6 beta-triol inhibits osteoblastic differentiation and promotes apoptosis of rat bone marrow stromal cells[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2005,96(1):198-208.
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