IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell
Cao, QZ; Lin, ZB
关键词Ganoderma lucidum polysaccharide peptide (Gl-PP) anti-angiogenesis human umbilical cord vascular endothelial cell (HUVEC) cell apoptosis VEGF
刊名LIFE SCIENCES
2006-02-23
DOI10.1016/j.lfs.2005.07.017
78期:13页:1457-1463
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]ANTI-ANGIOGENIC ACTIVITY ; INDUCIBLE FACTOR 1-ALPHA ; TUMOR ANGIOGENESIS ; ANTITUMOR-ACTIVITY ; ANNEXIN-V ; EXPRESSION ; MECHANISMS ; EXTRACTS ; CULTURE ; BREAST
英文摘要

Ganoderma lucidum Polysaccharide Peptide (Gl-PP) has shown some effects as anti-tumors in mice and potential anti-angiogenesis. In this study, we elucidated the possible mechanism of Gl-PP action oil anti-angiogenesis of tumor. Our research indicated that the proliferation of HUVECs was inhibited by Gl-PP in a dose-dependent fashion, but not because of cytotoxicity. Flow cytometric studies revealed that Gl-PP treatment of HUVECs could induce cell apoptosis directly. Moreover, addition of Gl-PP also led to a reduction of Bcl-2 anti-apoptotic protein expression and all increase of Bax pro-apoptotic protein expression of HUVECs. Therefore, inducing cell apoptosis by Gl-PP might be the mechanism of inhibiting HUVEC proliferation. Human lung carcinoma cells PG when exposed to high dose of Gl-PP in hypoxia for 18 h resulted in a decrease in the secreted VEGF. Taken together, these findings Support the hypothesis that the key attribute of the anti-angiogenic potential of Gl-PP is that it may directly inhibit vascular endothelial cell proliferation or indirectly decrease growth factor expression of tumor cells. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000235651400008
引用统计
被引频次:85[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65612
专题北京大学基础医学院_药理学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Sch Basic Med Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Cao, QZ,Lin, ZB. Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell[J]. LIFE SCIENCES,2006,78(13):1457-1463.
APA Cao, QZ,&Lin, ZB.(2006).Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell.LIFE SCIENCES,78(13),1457-1463.
MLA Cao, QZ,et al."Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell".LIFE SCIENCES 78.13(2006):1457-1463.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Ganoderma lucidum po(300KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Cao, QZ]的文章
[Lin, ZB]的文章
百度学术
百度学术中相似的文章
[Cao, QZ]的文章
[Lin, ZB]的文章
必应学术
必应学术中相似的文章
[Cao, QZ]的文章
[Lin, ZB]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。