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学科主题: 基础医学
题名:
Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell
作者: Cao, QZ; Lin, ZB
关键词: Ganoderma lucidum polysaccharide peptide (Gl-PP) ; anti-angiogenesis ; human umbilical cord vascular endothelial cell (HUVEC) ; cell apoptosis ; VEGF
刊名: LIFE SCIENCES
发表日期: 2006-02-23
DOI: 10.1016/j.lfs.2005.07.017
卷: 78, 期:13, 页:1457-1463
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: ANTI-ANGIOGENIC ACTIVITY ; INDUCIBLE FACTOR 1-ALPHA ; TUMOR ANGIOGENESIS ; ANTITUMOR-ACTIVITY ; ANNEXIN-V ; EXPRESSION ; MECHANISMS ; EXTRACTS ; CULTURE ; BREAST
英文摘要:

Ganoderma lucidum Polysaccharide Peptide (Gl-PP) has shown some effects as anti-tumors in mice and potential anti-angiogenesis. In this study, we elucidated the possible mechanism of Gl-PP action oil anti-angiogenesis of tumor. Our research indicated that the proliferation of HUVECs was inhibited by Gl-PP in a dose-dependent fashion, but not because of cytotoxicity. Flow cytometric studies revealed that Gl-PP treatment of HUVECs could induce cell apoptosis directly. Moreover, addition of Gl-PP also led to a reduction of Bcl-2 anti-apoptotic protein expression and all increase of Bax pro-apoptotic protein expression of HUVECs. Therefore, inducing cell apoptosis by Gl-PP might be the mechanism of inhibiting HUVEC proliferation. Human lung carcinoma cells PG when exposed to high dose of Gl-PP in hypoxia for 18 h resulted in a decrease in the secreted VEGF. Taken together, these findings Support the hypothesis that the key attribute of the anti-angiogenic potential of Gl-PP is that it may directly inhibit vascular endothelial cell proliferation or indirectly decrease growth factor expression of tumor cells. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000235651400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65612
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Sch Basic Med Sci, Beijing 100083, Peoples R China

Recommended Citation:
Cao, QZ,Lin, ZB. Ganoderma lucidum polysaccharides peptide inhibits the growth of vascular endothelial cell and the induction of VEGF in human lung cancer cell[J]. LIFE SCIENCES,2006,78(13):1457-1463.
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