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学科主题: 医学信息学
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Vitamin E intake from natural sources and head and neck cancer risk: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium
作者: Edefonti, V.1; Hashibe, M.2,3; Parpinel, M.4; Ferraroni, M.1; Turati, F.5; Serraino, D.6; Matsuo, K.7; Olshan, A. F.8; Zevallos, J. P.9; Winn, D. M.10; Moysich, K.11; Zhang, Z-F12; Morgenstern, H.13,14,15; Levi, F.16; Kelsey, K.17; McClean, M.18; Bosetti, C.19; Schantz, S.20; Yu, G-P21; Boffetta, P.22,23; Chuang, S-C24; Lee, Y-C A.25; La Vecchia, C.1; Decarli, A.1
关键词: head and neck cancer ; INHANCE ; laryngeal cancer ; oral and pharyngeal cancer ; vitamin E
刊名: BRITISH JOURNAL OF CANCER
发表日期: 2015-06-30
DOI: 10.1038/bjc.2015.149
卷: 113, 期:1, 页:182-192
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: UPPER AERODIGESTIVE TRACT ; SQUAMOUS-CELL CARCINOMA ; PHARYNGEAL CANCER ; ORAL-CANCER ; ANTIOXIDANT VITAMINS ; LARYNGEAL-CANCER ; DIETARY PATTERNS ; SERUM MICRONUTRIENTS ; ESOPHAGEAL CANCER ; ALPHA-TOCOPHEROL
英文摘要:

Background: Evidence for the possible effect of vitamin E on head and neck cancers (HNCs) is limited.

Methods: We used individual-level pooled data from 10 case-control studies (5959 cases and 12 248 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium to assess the association between vitamin E intake from natural sources and cancer of the oral cavity/pharynx and larynx. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models applied to quintile categories of nonalcohol energy-adjusted vitamin E intake.

Results: Intake of vitamin E was inversely related to oral/pharyngeal cancer (OR for the fifth vs the first quintile category = 0.59, 95% CI: 0.49-0.71; P for trend <0.001) and to laryngeal cancer (OR = 0.67, 95% CI: 0.54-0.83, P for trend <0.001). There was, however, appreciable heterogeneity of the estimated effect across studies for oral/pharyngeal cancer. Inverse associations were generally observed for the anatomical subsites of oral and pharyngeal cancer and within covariate strata for both sites.

Conclusion: Our findings suggest that greater vitamin E intake from foods may lower HNC risk, although we were not able to explain the heterogeneity observed across studies or rule out certain sources of bias.

语种: 英语
所属项目编号: R03CA113157 ; R03DE016611 ; KFS-700 ; OCS-1633 ; P50CA090388 ; R01DA011386 ; R03CA077954 ; T32CA009142 ; U01CA096134 ; R21ES011667 ; R01CA078609 ; R01CA100679 ; R01CA051845 ; 20012005 ; 17015052 ; 10068 ; PRIN 2009 X8YCBN
项目资助者: National Institutes of Health (NIH), National Cancer Institute, (NCI) ; NIDCR ; Italy Multicenter study: Italian Association for Research on Cancer (AIRC) ; Italy Multicenter study: Italian League Against Cancer ; Italy Multicenter study: Italian Ministry of Research ; Swiss study: Swiss Research against Cancer/Oncosuisse ; Los Angeles study: NIH ; Los Angeles study: Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center ; Boston study: NIH ; US multicenter study: Intramural Program of the NCI, NIH, USA ; MSKCC study: NIH ; Japan study: Scientific Research grant from the Ministry of Education, Science, Sports, Culture and Technology of Japan ; North Carolina study ; Buffalo study ; Milan study: Italian Association for Cancer Research (AIRC) ; Milan study: Italian Foundation for Cancer Research (FIRC) ; Milan study: Italian Ministry of Education ; FIRC ; Japan study: Ministry of Health, Labor and Welfare of Japan
WOS记录号: WOS:000357188500026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65619
Appears in Collections:北京大学医学信息学中心_期刊论文

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作者单位: 1.Univ Udine, Dept Med & Biol Sci, I-33100 Udine, Italy
2.Roswell Pk Canc Inst, Buffalo, NY 14263 USA
3.Brown Univ, Dept Pathol & Lab Med, Providence, RI 02912 USA
4.Univ Milan, Lab Stat Med Biometria Epidemiol GA Maccacaro, Dipartimento Sci Clin & Comunita, I-20133 Milan, Italy
5.Univ Utah, Sch Med, Div Publ Hlth, Dept Family & Prevent Med, Salt Lake City, UT 84108 USA
6.Univ Utah, Sch Med, Huntsman Canc Inst, Salt Lake City, UT 84108 USA
7.Fdn IRCSS Ist Nazl Tumori Milano, SC Stat Med Biometria & Bioinformat, I-20133 Milan, Italy
8.IRCCS, CRO Aviano Natl Canc Inst, Epidemiol & Biostat Unit, I-33081 Aviano, PN, Italy
9.Kyushu Univ, Fac Med Sci, Dept Prevent Med, Higashi Ku, Fukuoka 8128582, Japan
10.Univ N Carolina, Sch Publ Hlth, Chapel Hill, NC USA
11.Univ N Carolina, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27599 USA
12.NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA
13.Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90095 USA
14.Univ Michigan, Dept Epidemiol, Sch Publ Hlth, Ann Arbor, MI USA
15.Univ Michigan, Dept Environm Hlth Sci, Sch Publ Hlth, Ann Arbor, MI USA
16.Univ Michigan, Ctr Comprehens Canc, Ann Arbor, MI USA
17.Lausanne Univ Hosp CHUV, Inst Social & Prevent Med IUMSP, CH-1010 Lausanne, Switzerland
18.Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02118 USA
19.IRCCS Ist Ric Farmacol Mario Negri, Dept Epidemiol, I-20156 Milan, Italy
20.Natl Hlth Res Inst, Inst Populat Hlth Sci, Zhunan, Miaoli County, Taiwan
21.Univ Utah, Sch Med, Dept Family & Prevent Med, Divis Publ Hlth, Salt Lake City, UT 84108 USA
22.New York Eye & Ear Infirm, Dept Otolaryngol, New York, NY 10003 USA
23.Peking Univ, Med Informat Ctr, Beijing, Peoples R China
24.Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA
25.Icahn Sch Med Mt Sinai, Inst Translat Epidemiol, New York, NY 10029 USA

Recommended Citation:
Edefonti, V.,Hashibe, M.,Parpinel, M.,et al. Vitamin E intake from natural sources and head and neck cancer risk: a pooled analysis in the International Head and Neck Cancer Epidemiology consortium[J]. BRITISH JOURNAL OF CANCER,2015,113(1):182-192.
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