|Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analysis|
|Gao, L.1,2; Tao, Y.3; Zhang, L.4; Jin, Q.1,2|
|关键词||Vitamin D receptor tuberculosis polymorphism susceptibility meta-analysis|
|刊名||INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE|
|WOS标题词||Science & Technology|
|类目[WOS]||Infectious Diseases ; Respiratory System|
|研究领域[WOS]||Infectious Diseases ; Respiratory System|
|关键词[WOS]||PULMONARY TUBERCULOSIS ; MYCOBACTERIUM-TUBERCULOSIS ; REGION POLYMORPHISMS ; FOKI POLYMORPHISMS ; REGULATORY ROLE ; SUSCEPTIBILITY ; VARIANTS ; RISK ; HIV ; ASSOCIATION|
BACKGROUND: Host genetic susceptibility has been suggested as one of the most important explanations for inter-individual differences in tuberculosis (TB) risk. The vitamin D receptor (VDR) gene has been studied as a candidate locus due to genetic polymorphisms that affects the activity of the receptor and subsequent downstream vitamin D-mediated effects.
METHODS: We reviewed published studies on VDR polymorphisms and TB susceptibility up to 15 April 2009 and quantitatively summarised associations of the most widely studied polymorphisms (FokI, TaqI, ApaI and BsmI) using meta-analysis.
RESULTS: A total of 23 eligible studies were included in this review. Heterogeneous results were observed, which may be partly explained by the differences between populations. Among Asians, the FokI ff genotype showed a pronounced positive association (OR 2.0, 95%CI 1.3-3.2), a significant inverse association was observed for the BsmI bb genotype (OR 0.5, 95%CI 0.4-0.8), and marginal significant associations were found for TaqI and ApaI polymorphisms. However, none of the polymorphisms was significantly related to TB among Africans or South Americans.
CONCLUSIONS: The association of VDR polymorphisms with risk of TB observed in our analyses supports the hypothesis that vitamin D deficiency might play a role as risk factor during the development of TB.
|作者单位||1.Chinese Acad Med Sci, Inst Pathogen Biol, Beijing 100730, Peoples R China|
2.Peking Union Med Coll, Beijing 100021, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
4.Beijing Ctr Dis Control & Prevent, Beijing, Peoples R China
|Gao, L.,Tao, Y.,Zhang, L.,et al. Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analysis[J]. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE,2010,14(1):15-23.|
|APA||Gao, L.,Tao, Y.,Zhang, L.,&Jin, Q..(2010).Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analysis.INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE,14(1),15-23.|
|MLA||Gao, L.,et al."Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analysis".INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE 14.1(2010):15-23.|