北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 眼科  > 期刊论文
学科主题: 临床医学
题名:
Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analysis
作者: Gao, L.1,2; Tao, Y.3; Zhang, L.4; Jin, Q.1,2
关键词: Vitamin D receptor ; tuberculosis ; polymorphism ; susceptibility ; meta-analysis
刊名: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
发表日期: 2010
卷: 14, 期:1, 页:15-23
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Respiratory System
研究领域[WOS]: Infectious Diseases ; Respiratory System
关键词[WOS]: PULMONARY TUBERCULOSIS ; MYCOBACTERIUM-TUBERCULOSIS ; REGION POLYMORPHISMS ; FOKI POLYMORPHISMS ; REGULATORY ROLE ; SUSCEPTIBILITY ; VARIANTS ; RISK ; HIV ; ASSOCIATION
英文摘要:

BACKGROUND: Host genetic susceptibility has been suggested as one of the most important explanations for inter-individual differences in tuberculosis (TB) risk. The vitamin D receptor (VDR) gene has been studied as a candidate locus due to genetic polymorphisms that affects the activity of the receptor and subsequent downstream vitamin D-mediated effects.

METHODS: We reviewed published studies on VDR polymorphisms and TB susceptibility up to 15 April 2009 and quantitatively summarised associations of the most widely studied polymorphisms (FokI, TaqI, ApaI and BsmI) using meta-analysis.

RESULTS: A total of 23 eligible studies were included in this review. Heterogeneous results were observed, which may be partly explained by the differences between populations. Among Asians, the FokI ff genotype showed a pronounced positive association (OR 2.0, 95%CI 1.3-3.2), a significant inverse association was observed for the BsmI bb genotype (OR 0.5, 95%CI 0.4-0.8), and marginal significant associations were found for TaqI and ApaI polymorphisms. However, none of the polymorphisms was significantly related to TB among Africans or South Americans.

CONCLUSIONS: The association of VDR polymorphisms with risk of TB observed in our analyses supports the hypothesis that vitamin D deficiency might play a role as risk factor during the development of TB.

语种: 英语
WOS记录号: WOS:000273311700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65624
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Chinese Acad Med Sci, Inst Pathogen Biol, Beijing 100730, Peoples R China
2.Peking Union Med Coll, Beijing 100021, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100871, Peoples R China
4.Beijing Ctr Dis Control & Prevent, Beijing, Peoples R China

Recommended Citation:
Gao, L.,Tao, Y.,Zhang, L.,et al. Vitamin D receptor genetic polymorphisms and tuberculosis: updated systematic review and meta-analysis[J]. INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE,2010,14(1):15-23.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gao, L.]'s Articles
[Tao, Y.]'s Articles
[Zhang, L.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gao, L.]‘s Articles
[Tao, Y.]‘s Articles
[Zhang, L.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace