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学科主题: 临床医学
题名:
Primary tumors of the spine: a review of clinical features in 438 patients
作者: Dang, Lei; Liu, Xiaoguang; Dang, Gengting; Jiang, Liang; Wei, Feng; Yu, Miao; Wu, Fengliang; Liu, Zhongjun
关键词: Neoplasm ; Vertebra ; Spine
刊名: JOURNAL OF NEURO-ONCOLOGY
发表日期: 2015-02-01
DOI: 10.1007/s11060-014-1650-8
卷: 121, 期:3, 页:513-520
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Clinical Neurology
研究领域[WOS]: Oncology ; Neurosciences & Neurology
关键词[WOS]: LANGERHANS-CELL HISTIOCYTOSIS ; PRIMARY BONE-TUMORS ; CERVICAL-SPINE ; CRANIOCERVICAL JUNCTION ; CORD NEOPLASMS ; MANAGEMENT ; EXPERIENCE ; DIAGNOSIS ; REGISTRY ; CHILDREN
英文摘要:

Primary spinal tumors are rare. Current knowledge on this subject is therefore limited due to the lack of study with large cohort. This study is prompted to share our data on clinical profiles of primary spinal tumors collected from a large series of patients. Clinical manifestations of 438 consecutive patients were summarized retrospectively with statistical analysis. In the spine, benign tumor is more common than malignant. The most prevalent tumor is giant cell tumor. Tumors predominately occur between the age of 18 and 59 and the risk of malignancy increases significantly after 40. Main symptoms include local pain and neurological symptoms with frequent occurrence of neurological deficits and pathological fracture. Pain is caused by tumor expansion, pathological fracture and nerve entrapment. Occurrence of neurological deficits is significantly related to patent′s age and the region of involvement. Giant cell tumor is associated with the highest incidence of neurological fracture with significance. Duration of symptom is 6 months on average. The most affected region is the cervical spine, followed by the thoracic and the lumbar spine. Tumors at the sacrum and coccyx are more likely to be malignant. Malignant tumors have significantly higher incidence of involvement at multiple levels than benign tumors. This study contributes by improving our understanding of this rare clinical entity.

语种: 英语
WOS记录号: WOS:000349527500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65630
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Orthopaed, Beijing 100191, Peoples R China

Recommended Citation:
Dang, Lei,Liu, Xiaoguang,Dang, Gengting,et al. Primary tumors of the spine: a review of clinical features in 438 patients[J]. JOURNAL OF NEURO-ONCOLOGY,2015,121(3):513-520.
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