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学科主题: 临床医学
题名:
Macrophage-inducible C-type lectin is associated with anti-cyclic citrullinated peptide antibodies-positive rheumatoid arthritis in men
作者: Wu Xin-yu1; Guo Jian-ping1; Yin Fang-rui2; Lu Xiao-lan1; Li Ru1; He Jing1; Liu Xu1; Li Zhan-guo1
关键词: rheumatoid arthritis ; macrophage-inducible C-type lectin ; genetic-association study ; cyclic citrullinated peptide ; men
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-09-05
DOI: 10.3760/cma.j.issn.0366-6999.2012.17.027
卷: 125, 期:17, 页:3115-3119
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: CANDIDA-ALBICANS ; RECEPTOR COMPLEX ; MINCLE ; GENE ; HLA-DRB1 ; PTPN22 ; CELLS
英文摘要:

Background Macrophage-inducible C-type lectin (MINCLE) is an important member of C-type lectin superfamily, which has been shown evidence for susceptibility to arthritis in animal models. We aimed to investigate the possible association of MINGLE with rheumatoid arthritis (RA) susceptibility in Chinese Han population.

Methods Haplotypes from HapMap database (Chinese Han Beijing, CHB) were used to select tag-single nucleotide polymorphism (SNP) (r(2)=0.8) residing in MINCLE gene. A total of 563 patients with RA and 404 healthy controls were TagMan genotyped for SNP rs10841845. Association analyses were performed on the whole data set and on RA subsets based on gender difference and the status of anti-cyclic citrullinated peptide (anti-CCP) antibody in RA patients. Association statistics were calculated by age and sex adjusted logistic regression.

Results Overall, MINCLE SNP rs10841845 was not associated with susceptibility to RA. However, following anti-CCP stratification, rs10841845 GG genotypes conferred a significantly protective effects against anti-CCP-positive RA (OR 0.65, 95% CI 0.430-0.995, P=0.048). Following gender stratification, SNP rs10841845 G allele appeared to insert its RA protective effect only in male patients, both at allele level (G vs. A OR 0.66, 95% CI 0.46-0.93, P=0.018) and at genotype level (GG vs. AA+AG, OR 0.429, 95% CI 0.20-0.95, P=0.036). Notably, the male RA protective effect of rs10841845 G allele was only seen in anti-CCP-positive RA (G vs. A: OR 0.64, 95% CI 0.43-0.96, P=0.029; GG vs. AA+AG: OR 0.375, 95% CI 0.14-0.94, P=0.038). Furthermore, we observed a significant reduction of Disease Activity Score (DAS) 28 score (3.91 +/- 0.70 vs. 5.66 +/- 0.31, P=0.022) and serum C-reactive protein levels (31.64 +/- 24.13 vs. 91.80 +/- 12.02, P=0.012) in male anti-CCP-positive RA patients carrying rs10841845 GG genotype, compared with patients carrying AA+AG genotypes.

Conclusions Our study provides the evidence for a gender specific association between MINCLE rs10841845 and RA susceptibility. The SNP rs10841845 G allele appears to have protective effect against anti-CCP-positive RA and confer reduced RA activity in men. Chin Med J 2012;125(17):3115-3119

语种: 英语
所属项目编号: 2010CB529100 ; S2011ZR0260 ; 81120108020
项目资助者: National Basic Research Program of China (973 Program) ; Ministry of Science and Technology ; National Natural Sciences Foundation of China
WOS记录号: WOS:000309378100028
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65632
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Baotou Med Coll, Affiliated Hosp 1, Dept Rheumatol, Baotou 014010, Inner Mongolia, Peoples R China

Recommended Citation:
Wu Xin-yu,Guo Jian-ping,Yin Fang-rui,et al. Macrophage-inducible C-type lectin is associated with anti-cyclic citrullinated peptide antibodies-positive rheumatoid arthritis in men[J]. CHINESE MEDICAL JOURNAL,2012,125(17):3115-3119.
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