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学科主题基础医学
ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex
Yang, Zhe; Zhang, Qiao; Lu, Qin; Jia, Zhuqing; Chen, Ping; Ma, Kangtao; Wang, Weiping; Zhou, Chunyan
关键词ISL-1 pancreatic islets PDX-1 proliferation Set7/9
刊名CELL CYCLE
2015-12-17
DOI10.1080/15384101.2015.1069926
14期:24页:3820-3829
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]HOMEOBOX GENE ISLET-1 ; ENDOCRINE PANCREAS ; BINDING-PROTEIN ; GROWTH-FACTOR ; BETA-CELLS ; EXPRESSION ; TRANSCRIPTION ; DIFFERENTIATION ; DOMAIN ; SET7/9
英文摘要

Islet-1 (ISL-1), a LIM-homeodomain transcription factor, has been recently found to be essential for promoting postnatal pancreatic islet proliferation. However, the detailed mechanism has not yet been elucidated. In the present study, we investigated the mechanism by which ISL-1 promotes -cell proliferation through regulation of CyclinD1 in HIT-T15 and NIT-1 cells, as well in rat islet mass. Our results provide the evidence that ISL-1 promotes adult pancreatic islet -cell proliferation by activating CyclinD1 transcription through cooperation with Set7/9 and PDX-1 to form an ISL-1/Set7/9/PDX-1 complex. This complex functions in an ISL-1-dependent manner, with Set7/9 functioning not only as a histone methyltransferase, which increases the histone H3K4 tri-methylation of the CyclinD1 promoter region, but also an adaptor to bridge ISL-1 and PDX-1, while PDX-1 functions as a RNA pol II binding modulator. Furthermore, the formation of the ISL-1/Set7/9/PDX-1 complex is positively associated with insulin-like growth factor-1 treatment in NIT and HIT-T15 cells in vitro, while may be negatively correlated with age in vivo.

语种英语
WOS记录号WOS:000367063200014
项目编号81170713 ; 81472022 ; 81370236 ; 81371889 ; 81071675 ; 5122021 ; B07001
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Leading Academic Discipline Project of Beijing Education Bureau ; 111 Project of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65636
专题北京大学基础医学院
北京大学药学院_药学院
作者单位Peking Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Key Lab Mol Cardiovasc Sci,Minist Educ China, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Yang, Zhe,Zhang, Qiao,Lu, Qin,et al. ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex[J]. CELL CYCLE,2015,14(24):3820-3829.
APA Yang, Zhe.,Zhang, Qiao.,Lu, Qin.,Jia, Zhuqing.,Chen, Ping.,...&Zhou, Chunyan.(2015).ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex.CELL CYCLE,14(24),3820-3829.
MLA Yang, Zhe,et al."ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex".CELL CYCLE 14.24(2015):3820-3829.
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