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学科主题: 基础医学
题名:
ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex
作者: Yang, Zhe; Zhang, Qiao; Lu, Qin; Jia, Zhuqing; Chen, Ping; Ma, Kangtao; Wang, Weiping; Zhou, Chunyan
关键词: ISL-1 ; pancreatic islets ; PDX-1 ; proliferation ; Set7/9
刊名: CELL CYCLE
发表日期: 2015-12-17
DOI: 10.1080/15384101.2015.1069926
卷: 14, 期:24, 页:3820-3829
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: HOMEOBOX GENE ISLET-1 ; ENDOCRINE PANCREAS ; BINDING-PROTEIN ; GROWTH-FACTOR ; BETA-CELLS ; EXPRESSION ; TRANSCRIPTION ; DIFFERENTIATION ; DOMAIN ; SET7/9
英文摘要:

Islet-1 (ISL-1), a LIM-homeodomain transcription factor, has been recently found to be essential for promoting postnatal pancreatic islet proliferation. However, the detailed mechanism has not yet been elucidated. In the present study, we investigated the mechanism by which ISL-1 promotes -cell proliferation through regulation of CyclinD1 in HIT-T15 and NIT-1 cells, as well in rat islet mass. Our results provide the evidence that ISL-1 promotes adult pancreatic islet -cell proliferation by activating CyclinD1 transcription through cooperation with Set7/9 and PDX-1 to form an ISL-1/Set7/9/PDX-1 complex. This complex functions in an ISL-1-dependent manner, with Set7/9 functioning not only as a histone methyltransferase, which increases the histone H3K4 tri-methylation of the CyclinD1 promoter region, but also an adaptor to bridge ISL-1 and PDX-1, while PDX-1 functions as a RNA pol II binding modulator. Furthermore, the formation of the ISL-1/Set7/9/PDX-1 complex is positively associated with insulin-like growth factor-1 treatment in NIT and HIT-T15 cells in vitro, while may be negatively correlated with age in vivo.

语种: 英语
所属项目编号: 81170713 ; 81472022 ; 81370236 ; 81371889 ; 81071675 ; 5122021 ; B07001
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Leading Academic Discipline Project of Beijing Education Bureau ; 111 Project of China
WOS记录号: WOS:000367063200014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65636
Appears in Collections:基础医学院_期刊论文

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作者单位: Peking Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Key Lab Mol Cardiovasc Sci,Minist Educ China, Beijing 100871, Peoples R China

Recommended Citation:
Yang, Zhe,Zhang, Qiao,Lu, Qin,et al. ISL-1 promotes pancreatic islet cell proliferation by forming an ISL-1/Set7/9/PDX-1 complex[J]. CELL CYCLE,2015,14(24):3820-3829.
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