IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Effect of Bone Morphogenetic Protein-12 Gene Transfer on Posterior Cruciate Ligament Healing in a Rabbit Model
Ma, Yong2; Zhang, Xin2; Wang, Jian2; Liu, Ping2; Zhao, Liheng2; Zhou, Chunyan1; Ao, Yingfang2
关键词posterior cruciate ligament bone morphogenetic protein-12 heal collagen
刊名AMERICAN JOURNAL OF SPORTS MEDICINE
2009-03-01
DOI10.1177/0363546508325960
37期:3页:599-609
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Orthopedics ; Sport Sciences
资助者National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China
研究领域[WOS]Orthopedics ; Sport Sciences
关键词[WOS]ANTERIOR CRUCIATE ; BIOMECHANICAL PROPERTIES ; DEFICIENT KNEE ; INJURIES ; COLLAGEN ; GROWTH ; DIFFERENTIATION ; ARTHROSCOPY ; ACCURACY ; REPAIR
英文摘要

Background: The posterior cruciate ligament heals to some extent after injury. However, results after conservative treatment may diminish with long-term follow-up. Bone morphogenetic protein-12 can induce formation of ligament tissues.

Hypothesis: Bone morphogenetic protein-12 gene transfer can improve the histologic and biomechanical properties of healing posterior cruciate ligaments.

Study Design: Controlled laboratory study.

Methods: Bilateral posterior cruciate ligaments of 32 rabbits were injured. The cut ends in 1 limb received an injection containing 3 x 10(7) pfu recombinant bone morphogenetic protein-12 adenovirus, and the posterior cruciate ligament in the contralateral limb served as an untreated control. Eight rabbits were sacrificed at each time point of 3, 6, 12, and 26 weeks after the operation. In addition, 6 rabbits receiving a sham operation were used to obtain normal control data. The posterior cruciate ligament specimens were evaluated biomechanically and histologically.

Results: The repair tissue of the treatment group at 26 weeks was similar to the normal posterior cruciate ligament in collagen arrangement, collagen formation, and mechanical properties. At weeks 6, 12, and 26, the ultimate load, stiffness, and energy absorbed at failure of the treatment group were significantly greater than those of the untreated group.

Conclusion: Adenovirus-mediated bone morphogenetic protein-12 gene transfer in a partial posterior cruciate ligament laceration rabbit model resulted in an obvious improvement of histologic properties, tensile strength, and stiffness of the repaired ligaments, indicating improved posterior cruciate ligament healing.

Clinical Relevance: Bone morphogenetic protein-12 gene transfer is a potential future strategy to improve the repair of injured posterior cruciate ligaments.

语种英语
所属项目编号30771049
资助者National Natural Sciences Foundation of China ; National Natural Sciences Foundation of China
WOS记录号WOS:000264218000019
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65642
Collection北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Inst Sports Med, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Ma, Yong,Zhang, Xin,Wang, Jian,et al. Effect of Bone Morphogenetic Protein-12 Gene Transfer on Posterior Cruciate Ligament Healing in a Rabbit Model[J]. AMERICAN JOURNAL OF SPORTS MEDICINE,2009,37(3):599-609.
APA Ma, Yong.,Zhang, Xin.,Wang, Jian.,Liu, Ping.,Zhao, Liheng.,...&Ao, Yingfang.(2009).Effect of Bone Morphogenetic Protein-12 Gene Transfer on Posterior Cruciate Ligament Healing in a Rabbit Model.AMERICAN JOURNAL OF SPORTS MEDICINE,37(3),599-609.
MLA Ma, Yong,et al."Effect of Bone Morphogenetic Protein-12 Gene Transfer on Posterior Cruciate Ligament Healing in a Rabbit Model".AMERICAN JOURNAL OF SPORTS MEDICINE 37.3(2009):599-609.
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