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学科主题: 基础医学
题名:
Effect of Bone Morphogenetic Protein-12 Gene Transfer on Posterior Cruciate Ligament Healing in a Rabbit Model
作者: Ma, Yong2; Zhang, Xin2; Wang, Jian2; Liu, Ping2; Zhao, Liheng2; Zhou, Chunyan1; Ao, Yingfang2
关键词: posterior cruciate ligament ; bone morphogenetic protein-12 ; heal ; collagen
刊名: AMERICAN JOURNAL OF SPORTS MEDICINE
发表日期: 2009-03-01
DOI: 10.1177/0363546508325960
卷: 37, 期:3, 页:599-609
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Orthopedics ; Sport Sciences
研究领域[WOS]: Orthopedics ; Sport Sciences
关键词[WOS]: ANTERIOR CRUCIATE ; BIOMECHANICAL PROPERTIES ; DEFICIENT KNEE ; INJURIES ; COLLAGEN ; GROWTH ; DIFFERENTIATION ; ARTHROSCOPY ; ACCURACY ; REPAIR
英文摘要:

Background: The posterior cruciate ligament heals to some extent after injury. However, results after conservative treatment may diminish with long-term follow-up. Bone morphogenetic protein-12 can induce formation of ligament tissues.

Hypothesis: Bone morphogenetic protein-12 gene transfer can improve the histologic and biomechanical properties of healing posterior cruciate ligaments.

Study Design: Controlled laboratory study.

Methods: Bilateral posterior cruciate ligaments of 32 rabbits were injured. The cut ends in 1 limb received an injection containing 3 x 10(7) pfu recombinant bone morphogenetic protein-12 adenovirus, and the posterior cruciate ligament in the contralateral limb served as an untreated control. Eight rabbits were sacrificed at each time point of 3, 6, 12, and 26 weeks after the operation. In addition, 6 rabbits receiving a sham operation were used to obtain normal control data. The posterior cruciate ligament specimens were evaluated biomechanically and histologically.

Results: The repair tissue of the treatment group at 26 weeks was similar to the normal posterior cruciate ligament in collagen arrangement, collagen formation, and mechanical properties. At weeks 6, 12, and 26, the ultimate load, stiffness, and energy absorbed at failure of the treatment group were significantly greater than those of the untreated group.

Conclusion: Adenovirus-mediated bone morphogenetic protein-12 gene transfer in a partial posterior cruciate ligament laceration rabbit model resulted in an obvious improvement of histologic properties, tensile strength, and stiffness of the repaired ligaments, indicating improved posterior cruciate ligament healing.

Clinical Relevance: Bone morphogenetic protein-12 gene transfer is a potential future strategy to improve the repair of injured posterior cruciate ligaments.

语种: 英语
所属项目编号: 30771049
项目资助者: National Natural Sciences Foundation of China
WOS记录号: WOS:000264218000019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65642
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Hlth Sci Ctr, Dept Biochem & Mol Biol, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Inst Sports Med, Beijing 100083, Peoples R China

Recommended Citation:
Ma, Yong,Zhang, Xin,Wang, Jian,et al. Effect of Bone Morphogenetic Protein-12 Gene Transfer on Posterior Cruciate Ligament Healing in a Rabbit Model[J]. AMERICAN JOURNAL OF SPORTS MEDICINE,2009,37(3):599-609.
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