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Clinical Predictors for Diagnosing Pandemic (H1N1) 2009 and Seasonal Influenza (H3N2) in Fever Clinics in Beijing, China
Dai Xiao Qiu1; Liu Min1; Zhang Tuo Hong2; Yang Xue Song3; Li Song Lin4; Li Xiao Guang3; Li Yu Ling4; Kadeerbai Hai San1; Wu Huang3
关键词Diagnosis Fever Influenza A, H1N1 H3N2 Signs, Symptoms
刊名BIOMEDICAL AND ENVIRONMENTAL SCIENCES
2012-02-01
DOI10.3967/0895-3988.2012.01.009
25期:1页:61-68
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Environmental Sciences ; Public, Environmental & Occupational Health
资助者Chinese National Programs for High Technology Research and Development (863 Program) ; Chinese National Programs for High Technology Research and Development (863 Program)
研究领域[WOS]Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]RELATIVE LYMPHOPENIA ; VIRUS-INFECTION ; UNITED-STATES ; ADULTS
英文摘要

Objective Symptomatic predictors of influenza could assess risks and improve decisions about isolation and outpatient treatment. To develop such predictors, we undertook a prospective analysis of pandemic (H1N1) 2009 and seasonal influenza (H3N2) in patients attending fever clinics.

Methods From 1 May 2009 to 1 January 2010, all adult patients admitted to fever clinics for suspected influenza, confirmed by real time RT-PCR, were enrolled. Predictors of influenza virus infection were selected with logistic regression models. Measures of sensitivity, specificity, positive and negative likelihood ratios (LRs) were calculated to identify the best predictors.

Results The clinical features and routine blood test results of influenza (H1N1) 2009 and seasonal influenza were similar. The positive and negative LRs of current US CDC influenza-like illness (ILI) criteria were modest in predicting influenza infection. Our modified clinic predictors improved the ability of the positive and negative LRs to recognize pandemic (H1N1) 2009 and seasonal influenza. The revised criteria are: fever >= 38 degrees C accompanied by at least one of the following-cough, arthralgia or relative lymphopenia.

Conclusion Patients with symptoms and signs that meet the new criteria are likely to have influenza and timely antiviral therapy may be appropriate. In addition, physicians should ascertain if influenza is circulating within the community or if there is a contact history of influenza and combine this information with the newly developed criteria to clinically diagnose influenza.

语种英语
所属项目编号2008AA02Z416
资助者Chinese National Programs for High Technology Research and Development (863 Program) ; Chinese National Programs for High Technology Research and Development (863 Program)
WOS记录号WOS:000301621900009
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65643
Collection北京大学公共卫生学院
作者单位1.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
2.Civil Aviat Gen Hosp, Beijing 100025, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Hlth Policy & Management, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Dai Xiao Qiu,Liu Min,Zhang Tuo Hong,et al. Clinical Predictors for Diagnosing Pandemic (H1N1) 2009 and Seasonal Influenza (H3N2) in Fever Clinics in Beijing, China[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2012,25(1):61-68.
APA Dai Xiao Qiu.,Liu Min.,Zhang Tuo Hong.,Yang Xue Song.,Li Song Lin.,...&Wu Huang.(2012).Clinical Predictors for Diagnosing Pandemic (H1N1) 2009 and Seasonal Influenza (H3N2) in Fever Clinics in Beijing, China.BIOMEDICAL AND ENVIRONMENTAL SCIENCES,25(1),61-68.
MLA Dai Xiao Qiu,et al."Clinical Predictors for Diagnosing Pandemic (H1N1) 2009 and Seasonal Influenza (H3N2) in Fever Clinics in Beijing, China".BIOMEDICAL AND ENVIRONMENTAL SCIENCES 25.1(2012):61-68.
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