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学科主题: 公共卫生
题名:
Clinical Predictors for Diagnosing Pandemic (H1N1) 2009 and Seasonal Influenza (H3N2) in Fever Clinics in Beijing, China
作者: Dai Xiao Qiu1; Liu Min1; Zhang Tuo Hong2; Yang Xue Song3; Li Song Lin4; Li Xiao Guang3; Li Yu Ling4; Kadeerbai Hai San1; Wu Huang3
关键词: Diagnosis ; Fever ; Influenza A, H1N1 ; H3N2 ; Signs, Symptoms
刊名: BIOMEDICAL AND ENVIRONMENTAL SCIENCES
发表日期: 2012-02-01
DOI: 10.3967/0895-3988.2012.01.009
卷: 25, 期:1, 页:61-68
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]: RELATIVE LYMPHOPENIA ; VIRUS-INFECTION ; UNITED-STATES ; ADULTS
英文摘要:

Objective Symptomatic predictors of influenza could assess risks and improve decisions about isolation and outpatient treatment. To develop such predictors, we undertook a prospective analysis of pandemic (H1N1) 2009 and seasonal influenza (H3N2) in patients attending fever clinics.

Methods From 1 May 2009 to 1 January 2010, all adult patients admitted to fever clinics for suspected influenza, confirmed by real time RT-PCR, were enrolled. Predictors of influenza virus infection were selected with logistic regression models. Measures of sensitivity, specificity, positive and negative likelihood ratios (LRs) were calculated to identify the best predictors.

Results The clinical features and routine blood test results of influenza (H1N1) 2009 and seasonal influenza were similar. The positive and negative LRs of current US CDC influenza-like illness (ILI) criteria were modest in predicting influenza infection. Our modified clinic predictors improved the ability of the positive and negative LRs to recognize pandemic (H1N1) 2009 and seasonal influenza. The revised criteria are: fever >= 38 degrees C accompanied by at least one of the following-cough, arthralgia or relative lymphopenia.

Conclusion Patients with symptoms and signs that meet the new criteria are likely to have influenza and timely antiviral therapy may be appropriate. In addition, physicians should ascertain if influenza is circulating within the community or if there is a contact history of influenza and combine this information with the newly developed criteria to clinically diagnose influenza.

语种: 英语
所属项目编号: 2008AA02Z416
项目资助者: Chinese National Programs for High Technology Research and Development (863 Program)
WOS记录号: WOS:000301621900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65643
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
2.Civil Aviat Gen Hosp, Beijing 100025, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Hlth Policy & Management, Beijing 100191, Peoples R China

Recommended Citation:
Dai Xiao Qiu,Liu Min,Zhang Tuo Hong,et al. Clinical Predictors for Diagnosing Pandemic (H1N1) 2009 and Seasonal Influenza (H3N2) in Fever Clinics in Beijing, China[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2012,25(1):61-68.
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