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学科主题临床医学
Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer
Ye, Lin1; Bokobza, Sivan1; Li, Jin1; Moazzam, Muhammad1; Chen, Jinfeng1,2; Mansel, Robert E.1; Jiang, Wen G.1
刊名CANCER SCIENCE
2010-10-01
DOI10.1111/j.1349-7006.2010.01648.x
101期:10页:2137-2144
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]PROSTATE-CANCER ; GROWTH-FACTOR ; EXPRESSION ; IDENTIFICATION ; PROLIFERATION ; METASTASIS ; INVASION ; BMP7 ; PROGRESSION ; RECEPTORS
英文摘要

Our recent study showed that a novel member of bone morphogenetic protein (BMP) family, BMP-10, was decreased in prostate cancer. In the present study, we investigated the implication of BMP-10 in breast cancer, particularly the relation of its expression with clinical aspects. The expression of BMP-10 was examined in a cohort of human breast cancer specimens (normal, n = 23; cancer, n = 97), using both quantitative real-time PCR and immunohistochemical staining. The full-length human BMP-10 was cloned into a mammalian expression plasmid vector and then transfected into breast cancer cells. The effect on growth, cell matrix adhesion, motility, and invasion of MDA-MB-231 cells by BMP-10 was then investigated using in vitro growth assays. Immunohistochemical staining and quantitative real-time PCR revealed a decreased expression of BMP-10 in breast cancer. Further analysis of BMP-10 transcript level against the clinical aspect demonstrated that the decreased BMP-10 expression correlated with disease progression, bone metastasis, and poor prognosis. The disease-free survival of the patients with a higher level of BMP-10 was 132.8 (95% CI, 122.0-143.5) months, significantly longer compared to 93.7 (95% CI, 60.3-127.2) months for patients with a lower level of BMP-10 expression (P = 0.043). The overexpression of BMP-10 has broad inhibitory effects on the in vitro growth, invasion, and motility of breast cancer cells. Taken together, BMP-10 can inhibit the cell growth of breast cancer cells, and decreased BMP-10 expression correlates to poor prognosis and disease progression, particularly the lymphatic and bone metastasis. Bone morphogenetic protein-10 (BMP-10) may function as a tumor suppressor in breast cancer. (Cancer Sci 2010).

语种英语
WOS记录号WOS:000282180200010
资助机构Cancer Research Wales
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65647
专题北京大学临床肿瘤学院_胸外科
北京大学临床肿瘤学院_胸部肿瘤外二科
作者单位1.Cardiff Univ, Sch Med, Dept Surg, Metastasis & Angiogenesis Res Grp, Cardiff, S Glam, Wales
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Thorac Surg, Beijing 100871, Peoples R China
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GB/T 7714
Ye, Lin,Bokobza, Sivan,Li, Jin,et al. Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer[J]. CANCER SCIENCE,2010,101(10):2137-2144.
APA Ye, Lin.,Bokobza, Sivan.,Li, Jin.,Moazzam, Muhammad.,Chen, Jinfeng.,...&Jiang, Wen G..(2010).Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer.CANCER SCIENCE,101(10),2137-2144.
MLA Ye, Lin,et al."Bone morphogenetic protein-10 (BMP-10) inhibits aggressiveness of breast cancer cells and correlates with poor prognosis in breast cancer".CANCER SCIENCE 101.10(2010):2137-2144.
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