|The possible involvement of genetic variants of NET1 in the etiology of attention-deficit/hyperactivity disorder comorbid with oppositional defiant disorder|
|Liu, Lu1,2; Cheng, Jia1,2; Li, Haimei1,2; Yang, Li1,2; Qian, Qiujin1,2; Wang, Yufeng1,2|
|关键词||ADHD ODD NET1 association|
|刊名||JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY|
|收录类别||SCI ; SSCI|
|WOS标题词||Social Sciences ; Science & Technology|
|类目[WOS]||Psychology, Developmental ; Psychiatry ; Psychology|
|研究领域[WOS]||Psychology ; Psychiatry|
|关键词[WOS]||DEFICIT-HYPERACTIVITY DISORDER ; NOREPINEPHRINE TRANSPORTER GENE ; SINGLE-NUCLEOTIDE POLYMORPHISMS ; CONDUCT DISORDER ; 3 DIMENSIONS ; ADHD ; ASSOCIATION ; SYMPTOMS ; CHILDREN ; SAMPLE|
BackgroundAttention-deficit/hyperactivity disorder (ADHD) and oppositional defiant disorder (ODD) often coexist and shared some genetic influences. Evidence from the existing literature indicated that comorbid with ODD may increase the heterogeneity of ADHD genetics. Our present study sought to investigate the role of norepinephrine transporter gene (NET1) for ADHD comorbid with ODD.
MethodsSix single nucleotide polymorphisms (SNPs) of NET1 were genotyped for a total of 1,815 ADHD cases, including 587 subjects (32.3%) with ODD. Chi-square tests were conducted for pseudo case-control study comparing allelic and genotypic distributions between ADHD with and without ODD. Among them, there were 1,249 probands together with their parents composing trios for family-based association studies using transmission disequilibrium tests (TDTs). In addition, 1,337 ADHD probands have detailed information of ODD symptoms and were included for quantitative analyses with genotypes using analyses of covariance (ANCOVA). To consider the overlap and correlation of other comorbidities with ODD and eliminate their potential confounding effect, we further repeated above analyses for pure ADHD+ODD′ versus ADHD-only′ after excluding other comorbidities except for ODD.
ResultsThe pseudo case-control study showed different allelic and genotypic distributions of SNP rs3785143 between ADHD with ODD and those without ODD. Family-based association tests indicated overtransmission of the T allele of rs3785143 in ADHD with ODD trios, but no biased transmission in those without ODD. ANCOVA showed association between genotypes of rs3785143 with ODD symptoms in ADHD probands, especially with Argumentative/Defiant Behavior (ADB)′ dimension after controlling gender, age, clinical subtypes and intelligence. Above association still existed after removing the samples with other comorbidities.
ConclusionNET1 was associated with comorbidity of ODD and ODD symptoms in ADHD probands. Our findings emphasize the importance of considering the comorbidity of ODD in ADHD genetic studies, especially ADHD with ADB. However, further replication in independent sample or different populations is still needed.
|项目编号||81301171 ; 2014CB8 46104 ; NCET-11-0013|
|资助机构||National Natural Science Foundation of China ; National Basic Research Program of China (973 program) ; Program for New Century Excellent Talents in University|
|作者单位||1.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100871, Peoples R China|
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
|Liu, Lu,Cheng, Jia,Li, Haimei,et al. The possible involvement of genetic variants of NET1 in the etiology of attention-deficit/hyperactivity disorder comorbid with oppositional defiant disorder[J]. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY,2015,56(1):58-66.|
|APA||Liu, Lu,Cheng, Jia,Li, Haimei,Yang, Li,Qian, Qiujin,&Wang, Yufeng.(2015).The possible involvement of genetic variants of NET1 in the etiology of attention-deficit/hyperactivity disorder comorbid with oppositional defiant disorder.JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY,56(1),58-66.|
|MLA||Liu, Lu,et al."The possible involvement of genetic variants of NET1 in the etiology of attention-deficit/hyperactivity disorder comorbid with oppositional defiant disorder".JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY 56.1(2015):58-66.|