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学科主题: 基础医学
题名:
Involvement of ionotropic glutamate receptors in low frequency. electroacupuncture analgesia in rats
作者: Choi, BT; Lee, JH; Wan, Y; Han, JS
关键词: electroacupuncture ; NMDA ; AMPA ; KA
刊名: NEUROSCIENCE LETTERS
发表日期: 2005-04-04
DOI: 10.1016/j.neulet.2004.11.095
卷: 377, 期:3, 页:185-188
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: LONG-TERM DEPRESSION ; A-DELTA-FIBERS ; FIELD POTENTIALS ; DORSAL-HORN ; STIMULATION ; SYNAPSES ; AFFERENT ; PAIN ; HYPERALGESIA ; ANTAGONISTS
英文摘要:

The present study was conducted to determine whether blockage of both N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid/kainate (AMPA/KA) receptors influences the induction of low frequency electroacupuncture (EA) analgesia. Although neither intrathecal injection of NMDA antagonist D-2-amino-5-phosphonopentanoic acid (D-AP-5) or AMPA/KA antagonist 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonami-de (NBQX) disodium alone had an effect on analgesia, spinal application Of D-AP-5 and NBQX disodium significantly prevented analgesia induced by 2 Hz EA. The intrathecal injection of the excitatory amino acid NMDA produced analgesia for several minutes after intrathecal injection, as did EA stimulation. These results suggest that ionotropic glutamate receptors may be involved in the induction of 2 Hz EA analgesia. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000227750000009
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65655
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Dong Eui Univ, Res Inst Oriental Med, Coll Oriental Med, Dept Anat, Pusan 614052, South Korea
2.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Choi, BT,Lee, JH,Wan, Y,et al. Involvement of ionotropic glutamate receptors in low frequency. electroacupuncture analgesia in rats[J]. NEUROSCIENCE LETTERS,2005,377(3):185-188.
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