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Involvement of ionotropic glutamate receptors in low frequency. electroacupuncture analgesia in rats
Choi, BT; Lee, JH; Wan, Y; Han, JS
关键词electroacupuncture NMDA AMPA KA
刊名NEUROSCIENCE LETTERS
2005-04-04
DOI10.1016/j.neulet.2004.11.095
377期:3页:185-188
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]LONG-TERM DEPRESSION ; A-DELTA-FIBERS ; FIELD POTENTIALS ; DORSAL-HORN ; STIMULATION ; SYNAPSES ; AFFERENT ; PAIN ; HYPERALGESIA ; ANTAGONISTS
英文摘要

The present study was conducted to determine whether blockage of both N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid/kainate (AMPA/KA) receptors influences the induction of low frequency electroacupuncture (EA) analgesia. Although neither intrathecal injection of NMDA antagonist D-2-amino-5-phosphonopentanoic acid (D-AP-5) or AMPA/KA antagonist 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonami-de (NBQX) disodium alone had an effect on analgesia, spinal application Of D-AP-5 and NBQX disodium significantly prevented analgesia induced by 2 Hz EA. The intrathecal injection of the excitatory amino acid NMDA produced analgesia for several minutes after intrathecal injection, as did EA stimulation. These results suggest that ionotropic glutamate receptors may be involved in the induction of 2 Hz EA analgesia. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000227750000009
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65655
专题基础医学院_神经生物学系
作者单位1.Dong Eui Univ, Res Inst Oriental Med, Coll Oriental Med, Dept Anat, Pusan 614052, South Korea
2.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100083, Peoples R China
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GB/T 7714
Choi, BT,Lee, JH,Wan, Y,et al. Involvement of ionotropic glutamate receptors in low frequency. electroacupuncture analgesia in rats[J]. NEUROSCIENCE LETTERS,2005,377(3):185-188.
APA Choi, BT,Lee, JH,Wan, Y,&Han, JS.(2005).Involvement of ionotropic glutamate receptors in low frequency. electroacupuncture analgesia in rats.NEUROSCIENCE LETTERS,377(3),185-188.
MLA Choi, BT,et al."Involvement of ionotropic glutamate receptors in low frequency. electroacupuncture analgesia in rats".NEUROSCIENCE LETTERS 377.3(2005):185-188.
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