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Inhibition of Period1 Gene Attenuates the Morphine-Induced ERK-CREB Activation in Frontal Cortex, Hippocampus, and Striatum in Mice
Li, Su-xia1,2; Wang, Zheng-rong2; Li, Jing3; Peng, Zu-gui3; Zhou, Wei4; Zhou, Mei1; Lu, Lin1
关键词Conditioned place preference deoxyribozyme period1 gene p-ERK p-CREB
刊名AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
2008
DOI10.1080/00952990802308197
34期:6页:673-682
收录类别SSCI
文章类型Article
WOS标题词Social Sciences ; Science & Technology
类目[WOS]Psychology, Clinical ; Substance Abuse
研究领域[WOS]Psychology ; Substance Abuse
关键词[WOS]SIGNAL-TRANSDUCTION CASCADE ; COCAINE SENSITIZATION ; SYNAPTIC PLASTICITY ; CIRCADIAN GENES ; CLOCK GENES ; MEMORY ; ADDICTION ; KINASE ; EXPRESSION ; DROSOPHILA
英文摘要

Objective: Recent studies demonstrated that the Period1 gene (Per1) is involved in behavioral alterations induced by addictive drugs. We explored the effects of inhibiting expression in brain of Per1 on morphine conditioned place preference (CPP) and morphine-induced phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element binding protein (CREB) in mice. Methods: During the first three sessions of conditioning, the male mice were intracerebroventricularlly (i.c.v.) injected with vehicle or deoxyribozyme 164 (DRz164) which cleaves per1 mRNA before subcutaneous (s.c.) injection morphine. The control group was given i.c.v. injection vehicle and s.c. injection saline instead of morphine. After testing CPP, mice were sacrificed and phosphorylated ERK and CREB in the frontal cortex, hippocampus, and striatum were examined by immunohistochemistry. Results: Mice pretreated with DRz164 did not acquire morphine CPP. Pretreatment with DRz164 significant attenuated the morphine-induced activation of ERK and CREB in the frontal cortex, hippocampus, and striatum. Conclusions: Our results indicated that per1 plays an important role in morphine reward, and ERK-CREB pathway was involved in the effects of per1. We suggested that per1 gene may be a potential treatment target for drug addition.

语种英语
WOS记录号WOS:000261018200002
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65656
Collection中国药物依赖性研究所
北京大学医学部管理机构_医学部
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Sichuan Univ, Key Lab Chronobiol, Minist Hlth, Basic & Forens Sch, Chengdu 610064, Peoples R China
3.Sichuan Univ, W China Hosp, Inst Mental Hlth, Chengdu 610064, Peoples R China
4.Shanghai Jiao Tong Univ, Basic Sch, Shanghai 200030, Peoples R China
Recommended Citation
GB/T 7714
Li, Su-xia,Wang, Zheng-rong,Li, Jing,et al. Inhibition of Period1 Gene Attenuates the Morphine-Induced ERK-CREB Activation in Frontal Cortex, Hippocampus, and Striatum in Mice[J]. AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE,2008,34(6):673-682.
APA Li, Su-xia.,Wang, Zheng-rong.,Li, Jing.,Peng, Zu-gui.,Zhou, Wei.,...&Lu, Lin.(2008).Inhibition of Period1 Gene Attenuates the Morphine-Induced ERK-CREB Activation in Frontal Cortex, Hippocampus, and Striatum in Mice.AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE,34(6),673-682.
MLA Li, Su-xia,et al."Inhibition of Period1 Gene Attenuates the Morphine-Induced ERK-CREB Activation in Frontal Cortex, Hippocampus, and Striatum in Mice".AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE 34.6(2008):673-682.
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