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学科主题: 药物依赖
题名:
Inhibition of Period1 Gene Attenuates the Morphine-Induced ERK-CREB Activation in Frontal Cortex, Hippocampus, and Striatum in Mice
作者: Li, Su-xia1,2; Wang, Zheng-rong2; Li, Jing3; Peng, Zu-gui3; Zhou, Wei4; Zhou, Mei1; Lu, Lin1
关键词: Conditioned place preference ; deoxyribozyme ; period1 gene ; p-ERK ; p-CREB
刊名: AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
发表日期: 2008
DOI: 10.1080/00952990802308197
卷: 34, 期:6, 页:673-682
收录类别: SSCI
文章类型: Article
WOS标题词: Social Sciences ; Science & Technology
类目[WOS]: Psychology, Clinical ; Substance Abuse
研究领域[WOS]: Psychology ; Substance Abuse
关键词[WOS]: SIGNAL-TRANSDUCTION CASCADE ; COCAINE SENSITIZATION ; SYNAPTIC PLASTICITY ; CIRCADIAN GENES ; CLOCK GENES ; MEMORY ; ADDICTION ; KINASE ; EXPRESSION ; DROSOPHILA
英文摘要:

Objective: Recent studies demonstrated that the Period1 gene (Per1) is involved in behavioral alterations induced by addictive drugs. We explored the effects of inhibiting expression in brain of Per1 on morphine conditioned place preference (CPP) and morphine-induced phosphorylation of extracellular signal-regulated kinase (ERK) and cAMP-response element binding protein (CREB) in mice. Methods: During the first three sessions of conditioning, the male mice were intracerebroventricularlly (i.c.v.) injected with vehicle or deoxyribozyme 164 (DRz164) which cleaves per1 mRNA before subcutaneous (s.c.) injection morphine. The control group was given i.c.v. injection vehicle and s.c. injection saline instead of morphine. After testing CPP, mice were sacrificed and phosphorylated ERK and CREB in the frontal cortex, hippocampus, and striatum were examined by immunohistochemistry. Results: Mice pretreated with DRz164 did not acquire morphine CPP. Pretreatment with DRz164 significant attenuated the morphine-induced activation of ERK and CREB in the frontal cortex, hippocampus, and striatum. Conclusions: Our results indicated that per1 plays an important role in morphine reward, and ERK-CREB pathway was involved in the effects of per1. We suggested that per1 gene may be a potential treatment target for drug addition.

语种: 英语
WOS记录号: WOS:000261018200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65656
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Sichuan Univ, Key Lab Chronobiol, Minist Hlth, Basic & Forens Sch, Chengdu 610064, Peoples R China
3.Sichuan Univ, W China Hosp, Inst Mental Hlth, Chengdu 610064, Peoples R China
4.Shanghai Jiao Tong Univ, Basic Sch, Shanghai 200030, Peoples R China

Recommended Citation:
Li, Su-xia,Wang, Zheng-rong,Li, Jing,et al. Inhibition of Period1 Gene Attenuates the Morphine-Induced ERK-CREB Activation in Frontal Cortex, Hippocampus, and Striatum in Mice[J]. AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE,2008,34(6):673-682.
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