IR@PKUHSC  > 北京大学第一临床医学院  > 临床药理研究所
学科主题临床医学
Antimicrobial resistance surveillance of doripenem in China
Li, Yun; Lv, Yuan; Xue, Feng; Zheng, Bo; Liu, Jian; Zhang, Jia
刊名JOURNAL OF ANTIBIOTICS
2015-08-01
DOI10.1038/ja.2015.25
68期:8页:496-500
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]IN-VITRO ACTIVITY ; CARBAPENEM ; S-4661
英文摘要

To investigate the antibacterial resistance to doripenem in China and to understand the distribution trends of resistant bacteria. All the clinical isolates were collected from hospitals and the susceptibility tests were performed using the agar dilution method recommended by the Clinical Laboratory Standards Institute (CLSI) central laboratory. The susceptibility of the isolates to antimicrobial agents was determined using the CLSI (2014) or European Committee on Antimicrobial Susceptibility Testing (EUCAST) (2013) guidelines. A total of 4047 pathogenic strains were isolated from 18 tertiary hospitals in 18 cities across China between July 2011 and June 2012. MIC results indicated that the vast majority of Enterobacteriaceae maintained high susceptibility to doripenem, with a lower resistance rate (1.9%) than that observed for other drugs tested. In the case of non-fermenting Gram-negative isolates, the resistance rate of Pseudomonas aeruginosa was 16.2%, which was less than that of imipenem and meropenem, and the Acinetobacter baumannii doripenem resistance rate was 67.4%. Doripenem also showed good in vitro activity against other the bacteria tested. This study suggests that the gradual increase in carbapenem nonsusceptible Enterobacteriaceae should be monitored carefully alongside the increasing multidrug-resistant and extensively drug-resistant A. baumannii.

语种英语
WOS记录号WOS:000360409800003
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65658
Collection北京大学第一临床医学院_临床药理研究所
作者单位Peking Univ First Hosp, Inst Clin Pharmacol, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Li, Yun,Lv, Yuan,Xue, Feng,et al. Antimicrobial resistance surveillance of doripenem in China[J]. JOURNAL OF ANTIBIOTICS,2015,68(8):496-500.
APA Li, Yun,Lv, Yuan,Xue, Feng,Zheng, Bo,Liu, Jian,&Zhang, Jia.(2015).Antimicrobial resistance surveillance of doripenem in China.JOURNAL OF ANTIBIOTICS,68(8),496-500.
MLA Li, Yun,et al."Antimicrobial resistance surveillance of doripenem in China".JOURNAL OF ANTIBIOTICS 68.8(2015):496-500.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Li, Yun]'s Articles
[Lv, Yuan]'s Articles
[Xue, Feng]'s Articles
百度学术
百度学术Similar articles in
[Li, Yun]'s Articles
[Lv, Yuan]'s Articles
[Xue, Feng]'s Articles
必应学术
必应学术Similar articles in
[Li, Yun]'s Articles
[Lv, Yuan]'s Articles
[Xue, Feng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.