北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 临床药理研究所  > 期刊论文
学科主题: 临床医学
题名:
Antimicrobial resistance surveillance of doripenem in China
作者: Li, Yun; Lv, Yuan; Xue, Feng; Zheng, Bo; Liu, Jian; Zhang, Jia
刊名: JOURNAL OF ANTIBIOTICS
发表日期: 2015-08-01
DOI: 10.1038/ja.2015.25
卷: 68, 期:8, 页:496-500
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]: Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]: IN-VITRO ACTIVITY ; CARBAPENEM ; S-4661
英文摘要:

To investigate the antibacterial resistance to doripenem in China and to understand the distribution trends of resistant bacteria. All the clinical isolates were collected from hospitals and the susceptibility tests were performed using the agar dilution method recommended by the Clinical Laboratory Standards Institute (CLSI) central laboratory. The susceptibility of the isolates to antimicrobial agents was determined using the CLSI (2014) or European Committee on Antimicrobial Susceptibility Testing (EUCAST) (2013) guidelines. A total of 4047 pathogenic strains were isolated from 18 tertiary hospitals in 18 cities across China between July 2011 and June 2012. MIC results indicated that the vast majority of Enterobacteriaceae maintained high susceptibility to doripenem, with a lower resistance rate (1.9%) than that observed for other drugs tested. In the case of non-fermenting Gram-negative isolates, the resistance rate of Pseudomonas aeruginosa was 16.2%, which was less than that of imipenem and meropenem, and the Acinetobacter baumannii doripenem resistance rate was 67.4%. Doripenem also showed good in vitro activity against other the bacteria tested. This study suggests that the gradual increase in carbapenem nonsusceptible Enterobacteriaceae should be monitored carefully alongside the increasing multidrug-resistant and extensively drug-resistant A. baumannii.

语种: 英语
WOS记录号: WOS:000360409800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65658
Appears in Collections:北京大学第一临床医学院_临床药理研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ First Hosp, Inst Clin Pharmacol, Beijing 100191, Peoples R China

Recommended Citation:
Li, Yun,Lv, Yuan,Xue, Feng,et al. Antimicrobial resistance surveillance of doripenem in China[J]. JOURNAL OF ANTIBIOTICS,2015,68(8):496-500.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, Yun]'s Articles
[Lv, Yuan]'s Articles
[Xue, Feng]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, Yun]‘s Articles
[Lv, Yuan]‘s Articles
[Xue, Feng]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace