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学科主题临床医学
Antimicrobial resistance surveillance of doripenem in China
Li, Yun; Lv, Yuan; Xue, Feng; Zheng, Bo; Liu, Jian; Zhang, Jia
刊名JOURNAL OF ANTIBIOTICS
2015-08-01
DOI10.1038/ja.2015.25
68期:8页:496-500
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy
关键词[WOS]IN-VITRO ACTIVITY ; CARBAPENEM ; S-4661
英文摘要

To investigate the antibacterial resistance to doripenem in China and to understand the distribution trends of resistant bacteria. All the clinical isolates were collected from hospitals and the susceptibility tests were performed using the agar dilution method recommended by the Clinical Laboratory Standards Institute (CLSI) central laboratory. The susceptibility of the isolates to antimicrobial agents was determined using the CLSI (2014) or European Committee on Antimicrobial Susceptibility Testing (EUCAST) (2013) guidelines. A total of 4047 pathogenic strains were isolated from 18 tertiary hospitals in 18 cities across China between July 2011 and June 2012. MIC results indicated that the vast majority of Enterobacteriaceae maintained high susceptibility to doripenem, with a lower resistance rate (1.9%) than that observed for other drugs tested. In the case of non-fermenting Gram-negative isolates, the resistance rate of Pseudomonas aeruginosa was 16.2%, which was less than that of imipenem and meropenem, and the Acinetobacter baumannii doripenem resistance rate was 67.4%. Doripenem also showed good in vitro activity against other the bacteria tested. This study suggests that the gradual increase in carbapenem nonsusceptible Enterobacteriaceae should be monitored carefully alongside the increasing multidrug-resistant and extensively drug-resistant A. baumannii.

语种英语
WOS记录号WOS:000360409800003
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65658
专题北京大学口腔医学院_口腔预防保健科
北京大学第一临床医学院_临床药理研究所
北京大学第三临床医学院_神经外科
作者单位Peking Univ First Hosp, Inst Clin Pharmacol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Yun,Lv, Yuan,Xue, Feng,et al. Antimicrobial resistance surveillance of doripenem in China[J]. JOURNAL OF ANTIBIOTICS,2015,68(8):496-500.
APA Li, Yun,Lv, Yuan,Xue, Feng,Zheng, Bo,Liu, Jian,&Zhang, Jia.(2015).Antimicrobial resistance surveillance of doripenem in China.JOURNAL OF ANTIBIOTICS,68(8),496-500.
MLA Li, Yun,et al."Antimicrobial resistance surveillance of doripenem in China".JOURNAL OF ANTIBIOTICS 68.8(2015):496-500.
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