| 学科主题 | 临床医学 |
| Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3 beta pathway | |
| Chen, Lin2,3; Zhang, Yi2; Sun, Xiuli4; Li, Hui2; LeSage, Gene2; Javer, Avani1; Zhang, Xiumei3; Wei, Xinbing3; Jiang, Yulin1; Yin, Deling2 | |
| 关键词 | TLR2 Resveratrol Apoptosis Akt GSK3 beta |
| 刊名 | BIOORGANIC & MEDICINAL CHEMISTRY
 |
| 2009-07-01 | |
| DOI | 10.1016/j.bmc.2009.05.029 |
| 卷 | 17期:13页:4378-4382 |
| 收录类别 | SCI |
| 文章类型 | Article |
| WOS标题词 | Science & Technology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic |
| 资助者 | National Institutes of Health (NIH) ; East Tennessee State University Research Development Committee ; Department of Chemistry ; National Institutes of Health (NIH) ; East Tennessee State University Research Development Committee ; Department of Chemistry |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | GLYCOGEN-SYNTHASE KINASE-3 ; BREAST-CANCER CELLS ; TOLL-LIKE RECEPTORS ; ADAPTIVE IMMUNITY ; INNATE IMMUNITY ; STRESS ; ACTIVATION ; TLR2 ; REGULATIONS ; RECOGNITION |
| 英文摘要 | As resveratrol derivatives, resveratrol aliphatic acids were synthesized in our laboratory. Previously, we reported the improved pharmaceutical properties of the compounds compared to resveratrol, including better solubility in water and much tighter binding with human serum albumin. Here, we investigate the role of resveratrol aliphatic acids in Toll-like receptor 2 (TLR2)-mediated apoptosis. We showed that resveratrol aliphatic acid (R6A) significantly inhibits the expression of TLR2. In addition, overexpression of TLR2 in HEK293 cells caused a significant decrease in apoptosis after R6A treatment. Moreover, inhibition of TLR2 by R6A decreases serum deprivation-reduced the levels of phosphorylated Akt and phosphorylated glycogen synthase kinase 3 beta (GSK3 beta). Our study thus demonstrates that the resveratrol aliphatic acid inhibits cell apoptosis through TLR2 by the involvement of Akt/GSK3 beta pathway. (C) 2009 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| 所属项目编号 | DA020120 ; RD09010 |
| 资助者 | National Institutes of Health (NIH) ; East Tennessee State University Research Development Committee ; Department of Chemistry ; National Institutes of Health (NIH) ; East Tennessee State University Research Development Committee ; Department of Chemistry |
| WOS记录号 | WOS:000266822900014 |
| Citation statistics | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/65666 |
| Collection | 北京大学第二临床医学院 |
| 作者单位 | 1.E Tennessee State Univ, Dept Chem, Johnson City, TN 37614 USA 2.E Tennessee State Univ, Coll Med, Dept Internal Med, Johnson City, TN 37614 USA 3.Shandong Univ, Sch Med, Dept Pharmacol, Jinan 250012, Peoples R China 4.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China |
| Recommended Citation GB/T 7714 | Chen, Lin,Zhang, Yi,Sun, Xiuli,et al. Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3 beta pathway[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2009,17(13):4378-4382. |
| APA | Chen, Lin.,Zhang, Yi.,Sun, Xiuli.,Li, Hui.,LeSage, Gene.,...&Yin, Deling.(2009).Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3 beta pathway.BIOORGANIC & MEDICINAL CHEMISTRY,17(13),4378-4382. |
| MLA | Chen, Lin,et al."Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3 beta pathway".BIOORGANIC & MEDICINAL CHEMISTRY 17.13(2009):4378-4382. |
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