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学科主题临床医学
Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3 beta pathway
Chen, Lin2,3; Zhang, Yi2; Sun, Xiuli4; Li, Hui2; LeSage, Gene2; Javer, Avani1; Zhang, Xiumei3; Wei, Xinbing3; Jiang, Yulin1; Yin, Deling2
关键词TLR2 Resveratrol Apoptosis Akt GSK3 beta
刊名BIOORGANIC & MEDICINAL CHEMISTRY
2009-07-01
DOI10.1016/j.bmc.2009.05.029
17期:13页:4378-4382
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]GLYCOGEN-SYNTHASE KINASE-3 ; BREAST-CANCER CELLS ; TOLL-LIKE RECEPTORS ; ADAPTIVE IMMUNITY ; INNATE IMMUNITY ; STRESS ; ACTIVATION ; TLR2 ; REGULATIONS ; RECOGNITION
英文摘要

As resveratrol derivatives, resveratrol aliphatic acids were synthesized in our laboratory. Previously, we reported the improved pharmaceutical properties of the compounds compared to resveratrol, including better solubility in water and much tighter binding with human serum albumin. Here, we investigate the role of resveratrol aliphatic acids in Toll-like receptor 2 (TLR2)-mediated apoptosis. We showed that resveratrol aliphatic acid (R6A) significantly inhibits the expression of TLR2. In addition, overexpression of TLR2 in HEK293 cells caused a significant decrease in apoptosis after R6A treatment. Moreover, inhibition of TLR2 by R6A decreases serum deprivation-reduced the levels of phosphorylated Akt and phosphorylated glycogen synthase kinase 3 beta (GSK3 beta). Our study thus demonstrates that the resveratrol aliphatic acid inhibits cell apoptosis through TLR2 by the involvement of Akt/GSK3 beta pathway. (C) 2009 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000266822900014
项目编号DA020120 ; RD09010
资助机构National Institutes of Health (NIH) ; East Tennessee State University Research Development Committee ; Department of Chemistry
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65666
专题北京大学第二临床医学院
作者单位1.E Tennessee State Univ, Dept Chem, Johnson City, TN 37614 USA
2.E Tennessee State Univ, Coll Med, Dept Internal Med, Johnson City, TN 37614 USA
3.Shandong Univ, Sch Med, Dept Pharmacol, Jinan 250012, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chen, Lin,Zhang, Yi,Sun, Xiuli,et al. Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3 beta pathway[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2009,17(13):4378-4382.
APA Chen, Lin.,Zhang, Yi.,Sun, Xiuli.,Li, Hui.,LeSage, Gene.,...&Yin, Deling.(2009).Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3 beta pathway.BIOORGANIC & MEDICINAL CHEMISTRY,17(13),4378-4382.
MLA Chen, Lin,et al."Synthetic resveratrol aliphatic acid inhibits TLR2-mediated apoptosis and an involvement of Akt/GSK3 beta pathway".BIOORGANIC & MEDICINAL CHEMISTRY 17.13(2009):4378-4382.
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