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Prolonged Thrombocytopenia Following Allogeneic Hematopoietic Stem Cell Transplantation and Its Association with a Reduction in Ploidy and an Immaturation of Megakaryocytes
Zhang, Xiaohui1; Fu, Haixia1; Xu, Lanping1; Liu, Daihong1; Wang, Jianzhong2; Liu, Kaiyan1; Huang, Xiaojun1
关键词Thrombocytopenia Megakaryocyte Ploidy Allogeneic hematopoietic stem cell transplantation
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2011-02-01
DOI10.1016/j.bbmt.2010.09.007
17期:2页:274-280
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
资助者National Science Foundation of China ; Program for Innovative Research Team in University ; National Science Foundation of China ; Program for Innovative Research Team in University
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; IDENTICAL SIBLING TRANSPLANTATION ; PLATELET PRODUCTION ; BLOOD ; RECOVERY ; COUNT
英文摘要

Prolonged thrombocytopenia is a frequent complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT); however, its pathogenesis has remained obscure. In the present study, we used flow cytometry to determine the frequency of bone marrow megakaryocytes (MKs) and MK ploidy distributions in allo-HSCT recipients with or without prolonged thrombocytopenia (n = 32 and 27, respectively) and healthy volunteers (n = 13). In addition, the expression of c-Mpl in MKs was measured. The results indicate that the proportions of MKs in marrow mononuclear cells or the percentages of CD 110(+) MKs in total MKs did not significantly differ between the 3 groups; however, in a comparison of nonthrombocytopenic allo-HSCT recipients to healthy volunteers, the allo-HSCT patients who had prolonged thrombocytopenia exhibited significant shifts toward low ploidy cells (left shift), which were accompanied by a marked increase in <= 8N cells (P =.036 and P <.001, respectively) and significant decreases in 16N cells (P <.001 and P <.001, respectively) and >= 32N cells (P =.01 and P <.001, respectively). These results indicate that there were more immature MKs in allo-HSCT recipients who had prolonged thrombocytopenia, in comparison to nonthrombocytopenic allo-HSCT recipients and healthy volunteers. We conclude that prolonged thrombocytopenia and slow platelet engraftment after allo-HSCT may be related to a reduction in ploidy and an immaturation of MKs. Biol Blood Marrow Transplant 17: 274-280 (2011) (C) 2011 American Society for Blood and Marrow Transplantation

语种英语
所属项目编号30770911 ; IRT 0702
资助者National Science Foundation of China ; Program for Innovative Research Team in University ; National Science Foundation of China ; Program for Innovative Research Team in University
WOS记录号WOS:000287350400013
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65669
专题北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
2.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Xiaohui,Fu, Haixia,Xu, Lanping,et al. Prolonged Thrombocytopenia Following Allogeneic Hematopoietic Stem Cell Transplantation and Its Association with a Reduction in Ploidy and an Immaturation of Megakaryocytes[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2011,17(2):274-280.
APA Zhang, Xiaohui.,Fu, Haixia.,Xu, Lanping.,Liu, Daihong.,Wang, Jianzhong.,...&Huang, Xiaojun.(2011).Prolonged Thrombocytopenia Following Allogeneic Hematopoietic Stem Cell Transplantation and Its Association with a Reduction in Ploidy and an Immaturation of Megakaryocytes.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,17(2),274-280.
MLA Zhang, Xiaohui,et al."Prolonged Thrombocytopenia Following Allogeneic Hematopoietic Stem Cell Transplantation and Its Association with a Reduction in Ploidy and an Immaturation of Megakaryocytes".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 17.2(2011):274-280.
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