IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科
学科主题临床医学
Lovastatin increases nitric oxide synthesis in IL-I beta- stimulated smooth muscle cells
Chen, H; Xing, Y; Liu, RH
关键词HMG-CoA reductase inhibitor inducible nitric oxide synthase atherosclerosis
刊名CHINESE MEDICAL JOURNAL
2001-11-01
114期:11页:1123-1127
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]SYNTHASE ; ATHEROSCLEROSIS ; RABBIT
英文摘要

Objective Nitric oxide (NO) production by inducible NO synthase (iNOS) may play an important role in the pathogenesis of atherosclerosis. Although lovastatin has been shown to reduce the progression of atherosclerosis, it is not known whether it regulates NO production. We investigated the effects of lovastatin on NO synthesis and the mechanisms by which lovastatin exerts its effects in rat vascular smooth muscle cells.

Methods Primary cultures of the vascular smooth muscle cells were obtained from the media of the thoracic aorta of Sprague Dawley rats (200 - 250 g). Nitrite levels in the culture medium of rat vascular smooth muscle cells were determined colorimetrically.

Results Lovastatin (10(-5) mol/L) significantly increased interleukin-1 beta (IL-1 beta, 10 ng/mL)-induced nitrite accumulation in a time (0 - 24 hours)-dependent manner, Exogenous mevalonate and geranylgeranyl-pyrophosphate completely reversed the stimulatory effects of lovastatin on nitrite production. Furthermore, inhibition of Rho by C3 exoenzyme mimicked the increase in IL-1 beta -induced nitrite accumulation induced by lovastatin in the vascular smooth muscle cells.

Conclusion These results demonstrate that lovastatin up-regulates NO formation in rat vascular smooth muscle cells stimulated by IL-1 beta, and the effect may be associated with the inhibition of Rho activity.

语种英语
WOS记录号WOS:000172271500001
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65673
专题北京大学第二临床医学院_心血管内科
作者单位Beijing Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Chen, H,Xing, Y,Liu, RH. Lovastatin increases nitric oxide synthesis in IL-I beta- stimulated smooth muscle cells[J]. CHINESE MEDICAL JOURNAL,2001,114(11):1123-1127.
APA Chen, H,Xing, Y,&Liu, RH.(2001).Lovastatin increases nitric oxide synthesis in IL-I beta- stimulated smooth muscle cells.CHINESE MEDICAL JOURNAL,114(11),1123-1127.
MLA Chen, H,et al."Lovastatin increases nitric oxide synthesis in IL-I beta- stimulated smooth muscle cells".CHINESE MEDICAL JOURNAL 114.11(2001):1123-1127.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, H]的文章
[Xing, Y]的文章
[Liu, RH]的文章
百度学术
百度学术中相似的文章
[Chen, H]的文章
[Xing, Y]的文章
[Liu, RH]的文章
必应学术
必应学术中相似的文章
[Chen, H]的文章
[Xing, Y]的文章
[Liu, RH]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。