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IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Lovastatin increases nitric oxide synthesis in IL-I beta- stimulated smooth muscle cells
作者: Chen, H; Xing, Y; Liu, RH
关键词: HMG-CoA reductase inhibitor ; inducible nitric oxide synthase ; atherosclerosis
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2001-11-01
卷: 114, 期:11, 页:1123-1127
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: SYNTHASE ; ATHEROSCLEROSIS ; RABBIT
英文摘要:

Objective Nitric oxide (NO) production by inducible NO synthase (iNOS) may play an important role in the pathogenesis of atherosclerosis. Although lovastatin has been shown to reduce the progression of atherosclerosis, it is not known whether it regulates NO production. We investigated the effects of lovastatin on NO synthesis and the mechanisms by which lovastatin exerts its effects in rat vascular smooth muscle cells.

Methods Primary cultures of the vascular smooth muscle cells were obtained from the media of the thoracic aorta of Sprague Dawley rats (200 - 250 g). Nitrite levels in the culture medium of rat vascular smooth muscle cells were determined colorimetrically.

Results Lovastatin (10(-5) mol/L) significantly increased interleukin-1 beta (IL-1 beta, 10 ng/mL)-induced nitrite accumulation in a time (0 - 24 hours)-dependent manner, Exogenous mevalonate and geranylgeranyl-pyrophosphate completely reversed the stimulatory effects of lovastatin on nitrite production. Furthermore, inhibition of Rho by C3 exoenzyme mimicked the increase in IL-1 beta -induced nitrite accumulation induced by lovastatin in the vascular smooth muscle cells.

Conclusion These results demonstrate that lovastatin up-regulates NO formation in rat vascular smooth muscle cells stimulated by IL-1 beta, and the effect may be associated with the inhibition of Rho activity.

语种: 英语
WOS记录号: WOS:000172271500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65673
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: Beijing Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Chen, H,Xing, Y,Liu, RH. Lovastatin increases nitric oxide synthesis in IL-I beta- stimulated smooth muscle cells[J]. CHINESE MEDICAL JOURNAL,2001,114(11):1123-1127.
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