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Lanthanum Enhances In Vitro Osteoblast Differentiation via Pertussis Toxin-Sensitive Gi Protein and ERK Signaling Pathway
Wang, Xi1; Yuan, Lan2; Huang, Jian1; Zhang, Tian-Lan1; Wang, Kui1
关键词LA(3+) OSTEOBLAST DIFFERENTIATION GI PROTEIN ERK PATHWAY
刊名JOURNAL OF CELLULAR BIOCHEMISTRY
2008-12-01
DOI10.1002/jcb.21932
105期:5页:1307-1315
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]CATION-SENSING MECHANISM ; CHRONIC-RENAL-FAILURE ; REGULATED KINASE ERK ; COUPLED RECEPTORS ; PHOSPHATE BINDER ; BONE-CELLS ; PROLIFERATION ; EXPRESSION ; IDENTIFICATION ; ACTIVATION
英文摘要

Converging lines of evidence suggest that lanthanum tends to deposit in bone. The influence of lanthanum ion (La3+) on osteoblast differentiation and the related mechanism are essential to understanding its effect on bone metabolism. In this study, La3+ treatment enhanced in vitro osteoblast differentiation as evidenced by promoting alkaline phosphatase (ALP) activity, osteocalcin (OC) secretion, and matrix mineralization. The expressions of osteoblast-specific genes of Cbfa-1, osteopontin (OPN), and bone sialoprotein (BSP) were all increased in the presence of La3+, but no change was observed in that of type I collagen (COL-I). Further studies demonstrated that La3+ treatment enhanced phosphorylation of extracellular signal-regulated kinase (ERK). Inhibition of ERK activation by U0126 suppressed the effects of La3+ on osteoblast activity. Moreover, pretreatment of the cells with pertussis toxin (PTx), a Gi protein inhibitor, suppressed the La3+-enhanced ERK phosphorylation and osteoblast differentiation. These findings suggest that La3+ exposure enhances in vitro osteoblast differentiation and the effect depends on ERK phosphorylation via PTx-sensitive Gi protein signaling. J. Cell. Biochem. 105: 1307-1315, 2008. (c) 2008 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000261539100018
项目编号2007CB516806 ; 20571006 ; 20637010 ; 2062007).
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; Natural Science Foundation of Beijing
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65676
专题北京大学药学院_化学生物学系
北京大学医学信息学中心
北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Med & Hlth Anal Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Xi,Yuan, Lan,Huang, Jian,et al. Lanthanum Enhances In Vitro Osteoblast Differentiation via Pertussis Toxin-Sensitive Gi Protein and ERK Signaling Pathway[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2008,105(5):1307-1315.
APA Wang, Xi,Yuan, Lan,Huang, Jian,Zhang, Tian-Lan,&Wang, Kui.(2008).Lanthanum Enhances In Vitro Osteoblast Differentiation via Pertussis Toxin-Sensitive Gi Protein and ERK Signaling Pathway.JOURNAL OF CELLULAR BIOCHEMISTRY,105(5),1307-1315.
MLA Wang, Xi,et al."Lanthanum Enhances In Vitro Osteoblast Differentiation via Pertussis Toxin-Sensitive Gi Protein and ERK Signaling Pathway".JOURNAL OF CELLULAR BIOCHEMISTRY 105.5(2008):1307-1315.
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