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The Permeability and the Efflux of Alkaloids of the Evodiae Fructus in the Caco-2 Model
Yang, Xiu-Wei1; Teng, Jie1,2; Wang, Ying1; Xu, Wei1
关键词Caco-2 cells rutaecarpine evodiamine dehydroevodiamine wuzhuyurutine B
刊名PHYTOTHERAPY RESEARCH
2009
DOI10.1002/ptr.2555
23期:1页:56-60
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]IN-VITRO ; INTESTINAL EPITHELIUM ; LIQUID-CHROMATOGRAPHY ; QUINOLONE ALKALOIDS ; CELL MONOLAYERS ; P-GLYCOPROTEIN ; TRANSPORT ; RUTAECARPA ; DEHYDROEVODIAMINE ; FRUITS
英文摘要

The intestinal transport of four indoloquinazoline alkaloids, rutaecarpine (RCP), evodiamine (EDM), dehydroevodiamine (DEDM) and wuzhuyurutine B (WZYB) isolated from the Evodiae fructus was investigated using the monolayers; of the human colon adenocarcinoma cell line Caco-2 as a model system for intestinal absorption. The four alkaloids were measured by high performance liquid chromatography (HPLC) coupled with UV detector. Transport parameters and permeability coefficients were then calculated and compared under identical conditions with those of mannitol, propranolol and paclitaxel. Permeability coefficients were also compared with the reported values for model compounds like propranolol and mannitol. The four alkaloids at a concentration of 5 mu M were demonstrated substantial transport across the Caco-2 cell monolayers with moderate to high permeability coefficients and WZYB demonstrated higher-level intestinal transcellular efflux. The transports of DEDM and WZYB were concentration dependent at the concentrations of 5-25 mu M. Among four alkaloids, EDM and DEDM are better-transported compounds, and RCP and WZYB are moderate transport compounds. The data support the involvement for multidrug resistance-associated proteins (MRPs) in the intestinal transcellular efflux of WZYB. Copyright (c) 2008 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000262567200009
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65678
专题北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, State Key Lab Nat & Biometr Drugs, Beijing 100083, Peoples R China
2.Tianjin Med Univ, Sch Pharmaceut Sci, Tianjin 300072, Peoples R China
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GB/T 7714
Yang, Xiu-Wei,Teng, Jie,Wang, Ying,et al. The Permeability and the Efflux of Alkaloids of the Evodiae Fructus in the Caco-2 Model[J]. PHYTOTHERAPY RESEARCH,2009,23(1):56-60.
APA Yang, Xiu-Wei,Teng, Jie,Wang, Ying,&Xu, Wei.(2009).The Permeability and the Efflux of Alkaloids of the Evodiae Fructus in the Caco-2 Model.PHYTOTHERAPY RESEARCH,23(1),56-60.
MLA Yang, Xiu-Wei,et al."The Permeability and the Efflux of Alkaloids of the Evodiae Fructus in the Caco-2 Model".PHYTOTHERAPY RESEARCH 23.1(2009):56-60.
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