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学科主题: 药学
题名:
The Permeability and the Efflux of Alkaloids of the Evodiae Fructus in the Caco-2 Model
作者: Yang, Xiu-Wei1; Teng, Jie1,2; Wang, Ying1; Xu, Wei1
关键词: Caco-2 cells rutaecarpine ; evodiamine ; dehydroevodiamine ; wuzhuyurutine B
刊名: PHYTOTHERAPY RESEARCH
发表日期: 2009
DOI: 10.1002/ptr.2555
卷: 23, 期:1, 页:56-60
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: IN-VITRO ; INTESTINAL EPITHELIUM ; LIQUID-CHROMATOGRAPHY ; QUINOLONE ALKALOIDS ; CELL MONOLAYERS ; P-GLYCOPROTEIN ; TRANSPORT ; RUTAECARPA ; DEHYDROEVODIAMINE ; FRUITS
英文摘要:

The intestinal transport of four indoloquinazoline alkaloids, rutaecarpine (RCP), evodiamine (EDM), dehydroevodiamine (DEDM) and wuzhuyurutine B (WZYB) isolated from the Evodiae fructus was investigated using the monolayers; of the human colon adenocarcinoma cell line Caco-2 as a model system for intestinal absorption. The four alkaloids were measured by high performance liquid chromatography (HPLC) coupled with UV detector. Transport parameters and permeability coefficients were then calculated and compared under identical conditions with those of mannitol, propranolol and paclitaxel. Permeability coefficients were also compared with the reported values for model compounds like propranolol and mannitol. The four alkaloids at a concentration of 5 mu M were demonstrated substantial transport across the Caco-2 cell monolayers with moderate to high permeability coefficients and WZYB demonstrated higher-level intestinal transcellular efflux. The transports of DEDM and WZYB were concentration dependent at the concentrations of 5-25 mu M. Among four alkaloids, EDM and DEDM are better-transported compounds, and RCP and WZYB are moderate transport compounds. The data support the involvement for multidrug resistance-associated proteins (MRPs) in the intestinal transcellular efflux of WZYB. Copyright (c) 2008 John Wiley & Sons, Ltd.

语种: 英语
WOS记录号: WOS:000262567200009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65678
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, State Key Lab Nat & Biometr Drugs, Beijing 100083, Peoples R China
2.Tianjin Med Univ, Sch Pharmaceut Sci, Tianjin 300072, Peoples R China

Recommended Citation:
Yang, Xiu-Wei,Teng, Jie,Wang, Ying,et al. The Permeability and the Efflux of Alkaloids of the Evodiae Fructus in the Caco-2 Model[J]. PHYTOTHERAPY RESEARCH,2009,23(1):56-60.
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