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学科主题: 临床医学
题名:
Increased CD8+ central memory T cells in patients with multiple sclerosis
作者: Liu, Guang-Zhi; Fang, Li-Bo; Hjelmstrom, Peter; Gao, Xu-Guang
关键词: CCR7 ; interleukin-15 ; memory T cell ; multiple sclerosis ; peripheral blood
刊名: MULTIPLE SCLEROSIS
发表日期: 2007-03-01
DOI: 10.1177/1352458506069246
卷: 13, 期:2, 页:149-155
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: MYELIN BASIC-PROTEIN ; IL-15 MESSENGER-RNA ; CEREBROSPINAL-FLUID ; MONONUCLEAR-CELLS ; CD8(+) ; SUBSETS ; DIFFERENTIATION ; COSTIMULATION ; LYMPHOCYTE ; IMMUNITY
英文摘要:

A T-cell-mediated autoimmune process against central nervous system myelin is believed to underlie the pathogenesis of multiple sclerosis (MS). Formation of immunological memory is based on the differentiation of naive T cells to memory T cells after exposure to antigens and specific cytokines. The aim of this study was to analyse peripheral blood mononuclear cells in patients with MS for different T-cell subsets including naive and memory T cells. Flow cytometry and enzyme-linked immunosorbent assay were used to analyse memory T-cell subsets and plasma concentration of interleukin-15 (IL-15) in peripheral blood of MS patients, patients with other neurological disorders and healthy controls. MS patients had a skewed distribution of T cells with an increased level of CD8+/CCR7+/CD45RA- central memory T cells (TCM) compared to healthy controls. In addition, MS patients showed significantly higher levels of plasma IL-15 than healthy controls did. Upregulated CD8+ TCM in MS patients may reflect a persistent chronic inflammatory response that may have been induced during early stages of the disease. This derangement may be important for maintaining chronic inflammation in MS.

语种: 英语
WOS记录号: WOS:000245792800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65680
Appears in Collections:北京大学第二临床医学院_神经内科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China
2.Capital Med Univ, Beijing Fuxing Hosp, Dept Neurol, Beijing 100038, Peoples R China
3.Karolinska Inst, Dept Clin Sci Intervent & Technol, SE-14186 Stockholm, Sweden

Recommended Citation:
Liu, Guang-Zhi,Fang, Li-Bo,Hjelmstrom, Peter,et al. Increased CD8+ central memory T cells in patients with multiple sclerosis[J]. MULTIPLE SCLEROSIS,2007,13(2):149-155.
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