学科主题基础医学
The biomechanical alterations in the CD14(+) monocytes of patients with living donor renal transplantation
Du, Yuan1; Sun, Xiaolu2,3; Shao, Qiang1; Zhang, Fengbo1; Wen, Zongyao4; Qian, Yeyong5; Shi, Bingyi5; Yao, Weijuan4; Tian, Ye1
关键词Living-donor renal transplantation CD14(+) monocytes cytoskeletal regulatory proteins
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2015
DOI10.3233/CH-141806
61期:1页:1-11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]ALLOGRAFT-REJECTION ; DENDRITIC CELLS ; MACROPHAGE ; MONOCYTES/MACROPHAGES ; KIDNEY ; ADF/COFILIN ; EXPRESSION ; RESPONSES ; SURVIVAL ; DIALYSIS
英文摘要

Living-donor renal transplantation is an ideal treatment for patients with end stage renal disease because it affords earlier transplantation and better graft for long term survival. CD14(+) monocytes are the predominant inflammatory cells in renal allograft intimal arteritis. The biomechanical alterations in CD14(+) monocytes would affect the function of graft. The aim of the present study was to explore the changes in the biorheological properties of CD14(+) monocytes before and after the living donor renal transplantation. We found that the viscoelastic properties of CD14(+) monocytes were greatly decreased after renal transplantation. Confocal microscopy showed that the F-actin content was increased when the oral immunosuppressive agents started. We also found that two cytoskeletal regulatory proteins, cofilin1 and profilin1, changed. Our results suggest that the immunosuppressive agents could significantly change the biorheological characteristics of the CD14(+) mononuclear cells and the biomechanical changes may greatly affects their function, which would play a critical role to gain longer immune-tolerance stage.

语种英语
WOS记录号WOS:000364130300001
项目编号31170886
资助机构National Natural Science Foundation of China ; Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Ministry
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65688
专题北京大学基础医学院_北京大学血液流变中心
作者单位1.Capital Med Univ, Beijing Friendship Hosp, Dept Urol, Beijing 100050, Peoples R China
2.Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Fuwai Hosp, Beijing 100730, Peoples R China
3.309th Hosp PLA, Dept Urol, Beijing, Peoples R China
4.Peking Union Med Coll, Beijing 100021, Peoples R China
5.Peking Univ Hlth Sci Ctr, Sch Basic Med Sci, Hemorheol Ctr, Beijing 100191, Peoples R China
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GB/T 7714
Du, Yuan,Sun, Xiaolu,Shao, Qiang,et al. The biomechanical alterations in the CD14(+) monocytes of patients with living donor renal transplantation[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2015,61(1):1-11.
APA Du, Yuan.,Sun, Xiaolu.,Shao, Qiang.,Zhang, Fengbo.,Wen, Zongyao.,...&Tian, Ye.(2015).The biomechanical alterations in the CD14(+) monocytes of patients with living donor renal transplantation.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,61(1),1-11.
MLA Du, Yuan,et al."The biomechanical alterations in the CD14(+) monocytes of patients with living donor renal transplantation".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 61.1(2015):1-11.
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