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学科主题: 临床医学
题名:
Plasma catestatin level in patients with acute myocardial infarction and its correlation with ventricular remodelling
作者: Meng, Lei1; Wang, Jie1; Ding, Wen-hui1; Han, Ping2; Yang, Ying1; Qi, Li-tong1; Zhang, Bao-wei1
刊名: POSTGRADUATE MEDICAL JOURNAL
发表日期: 2013-04-01
DOI: 10.1136/postgradmedj-2012-131060
卷: 89, 期:1050, 页:193-196
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: INHIBITORY PEPTIDE CATESTATIN ; CHROMOGRANIN-A FRAGMENT ; CATECHOLAMINE RELEASE ; PROGNOSTIC VALUE ; TIME-COURSE ; A(344-364) ; ACTIVATION ; ACTS
英文摘要:

Background The evaluation of ventricular remodelling and functional recovery is essential in predicting the prognosis of patients with acute myocardial infarction (AMI).

Objective To determine the plasma catestatin level in patients with AMI, and investigate the association between plasma catestatin and heart function, and with left ventricular remodelling (LVR).

Methods Fifty-eight consecutive patients who were admitted within 12 h of the onset of their ST-segment elevation myocardial infarction symptoms between 1 October 2009 and 30 June 2011 were prospectively recruited. Circulating catestatin was measured by ELISA. All patients underwent an echocardiography examination during the first week; 31 patients had a second echocardiography examination 3 months after the myocardial infarction.

Results Plasma catestatin at the time of admission was significantly higher in patients than in normal controls. The level increased further in the first week after AMI. Three months after AMI, the plasma catestatin level of patients was comparable to that of normal controls. The plasma level of catestatin correlated with anterior AMI and left ventricular ejection fraction (LVEF) in the acute stage. Compared with patients without LVR, those with LVR had significantly higher level of plasma brain natriuretic peptide on day 7 and a significantly higher level of plasma catestatin on admission and on days 3 and 7 (p=0.033, p=0.001, p=0.006, p=0.021, respectively).

Conclusions Plasma catestatin levels were raised after AMI. An early increase of catestatin correlated with anterior AMI and LVEF. Plasma catestatin after the onset of AMI might be associated with the magnitude of progressive ventricular remodelling 3 months after AMI.

语种: 英语
所属项目编号: 2009-3026
项目资助者: Medical Development of the Capital
WOS记录号: WOS:000316110300003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65700
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Beijing Haidian Hosp, Dept Cardiol, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China

Recommended Citation:
Meng, Lei,Wang, Jie,Ding, Wen-hui,et al. Plasma catestatin level in patients with acute myocardial infarction and its correlation with ventricular remodelling[J]. POSTGRADUATE MEDICAL JOURNAL,2013,89(1050):193-196.
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