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学科主题临床医学
Plasma catestatin level in patients with acute myocardial infarction and its correlation with ventricular remodelling
Meng, Lei1; Wang, Jie1; Ding, Wen-hui1; Han, Ping2; Yang, Ying1; Qi, Li-tong1; Zhang, Bao-wei1
刊名POSTGRADUATE MEDICAL JOURNAL
2013-04-01
DOI10.1136/postgradmedj-2012-131060
89期:1050页:193-196
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]INHIBITORY PEPTIDE CATESTATIN ; CHROMOGRANIN-A FRAGMENT ; CATECHOLAMINE RELEASE ; PROGNOSTIC VALUE ; TIME-COURSE ; A(344-364) ; ACTIVATION ; ACTS
英文摘要

Background The evaluation of ventricular remodelling and functional recovery is essential in predicting the prognosis of patients with acute myocardial infarction (AMI).

Objective To determine the plasma catestatin level in patients with AMI, and investigate the association between plasma catestatin and heart function, and with left ventricular remodelling (LVR).

Methods Fifty-eight consecutive patients who were admitted within 12 h of the onset of their ST-segment elevation myocardial infarction symptoms between 1 October 2009 and 30 June 2011 were prospectively recruited. Circulating catestatin was measured by ELISA. All patients underwent an echocardiography examination during the first week; 31 patients had a second echocardiography examination 3 months after the myocardial infarction.

Results Plasma catestatin at the time of admission was significantly higher in patients than in normal controls. The level increased further in the first week after AMI. Three months after AMI, the plasma catestatin level of patients was comparable to that of normal controls. The plasma level of catestatin correlated with anterior AMI and left ventricular ejection fraction (LVEF) in the acute stage. Compared with patients without LVR, those with LVR had significantly higher level of plasma brain natriuretic peptide on day 7 and a significantly higher level of plasma catestatin on admission and on days 3 and 7 (p=0.033, p=0.001, p=0.006, p=0.021, respectively).

Conclusions Plasma catestatin levels were raised after AMI. An early increase of catestatin correlated with anterior AMI and LVEF. Plasma catestatin after the onset of AMI might be associated with the magnitude of progressive ventricular remodelling 3 months after AMI.

语种英语
WOS记录号WOS:000316110300003
项目编号2009-3026
资助机构Medical Development of the Capital
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65700
专题北京大学第一临床医学院_心血管内科
作者单位1.Beijing Haidian Hosp, Dept Cardiol, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China
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GB/T 7714
Meng, Lei,Wang, Jie,Ding, Wen-hui,et al. Plasma catestatin level in patients with acute myocardial infarction and its correlation with ventricular remodelling[J]. POSTGRADUATE MEDICAL JOURNAL,2013,89(1050):193-196.
APA Meng, Lei.,Wang, Jie.,Ding, Wen-hui.,Han, Ping.,Yang, Ying.,...&Zhang, Bao-wei.(2013).Plasma catestatin level in patients with acute myocardial infarction and its correlation with ventricular remodelling.POSTGRADUATE MEDICAL JOURNAL,89(1050),193-196.
MLA Meng, Lei,et al."Plasma catestatin level in patients with acute myocardial infarction and its correlation with ventricular remodelling".POSTGRADUATE MEDICAL JOURNAL 89.1050(2013):193-196.
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