IR@PKUHSC  > 北京大学第一临床医学院  > 神经内科
学科主题临床医学
Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial
Sato, Shoichiro1,2; Arima, Hisatomi1,2; Heeley, Emma1,2; Hirakawa, Yoichiro1,2; Delcourt, Candice1,2; Lindley, Richard I.1,2; Robinson, Thompson3; Huang, Yining4; Morgenstern, Lewis5,6,7; Stapf, Christian8; Wang, Jiguang9; Chalmers, John1,2; Anderson, Craig S.1,2; INTERACT2 Investigators
关键词Intracerebral hemorrhage Hypertension Blood pressure Acute stroke care Clinical trials
刊名CEREBROVASCULAR DISEASES
2015
DOI10.1159/000434690
40期:3-4页:114-120
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Peripheral Vascular Disease
研究领域[WOS]Neurosciences & Neurology ; Cardiovascular System & Cardiology
关键词[WOS]ISCHEMIC-STROKE ; CASE-FATALITY ; WEEKEND ; MORTALITY ; CARE ; ASSOCIATION ; COHORT ; TIME
英文摘要

Background: Conflicting data exist of an association between off-hour (weekend, holiday, or night-time) hospital admission and adverse outcome in intracerebral hemorrhage (ICH). We determined the association between off-hour admissions and poor clinical outcome, and of any differential effect of early intensive blood pressure (BP) lowering treatment between off-and on-hour admissions, among participants of the Intensive BP Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Subsidiary analysis of INTERACT2, a multinational, multicenter, clinical trial of patients with spontaneous ICH with elevated systolic BP, randomly assigned to intensive (target systolic BP < 140 mm Hg) or guideline-based (< 180 mm Hg) BP management. Primary outcome was death or major disability (modified Rankin scale of 3-6) at 90 days. Off-hour admission was defined as night-time (4: 30 p.m. to 8: 30 a.m.) on weekdays, weekends (Saturday and Sunday), and public holidays in each participating country. Results: Of 2,794 patients with information on the primary outcome, 1,770 (63%) were admitted to study centers during off-hours. Off-hour admission was not associated with risk of poor outcome at 90 days (53% off-hour vs. 55% on-hour; p = 0.49), even after adjustment for comorbid risk factors (odds ratio 0.92; 95% CI 0.76-1.12). Consistency exists in the effects of intensive BP lowering between off-and on-hour admission (p = 0.85 for homogeneity). Conclusions: Off-hour admission was not associated with increased risks of death or major disability among trial protocol participants with acute ICH. Intensive BP lowering can provide similar treatment effect irrespective of admission hours. (C) 2015 S. Karger AG, Basel

语种英语
WOS记录号WOS:000361496900003
资助机构National Health and Medical Research Council of Australia
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65701
专题北京大学第一临床医学院_神经内科
作者单位1.Univ Sydney, George Inst Global Hlth, Sydney, NSW 2006, Australia
2.Royal Prince Alfred Hosp, Sydney, NSW, Australia
3.Univ Leicester, NIHR Biomed Res Unit Cardiovasc Dis, Dept Cardiovasc Sci, Leicester, Leics, England
4.Peking Univ, Hosp 1, Dept Neurol, Beijing 100871, Peoples R China
5.Univ Michigan, Sch Med, Stroke Program, Ann Arbor, MI USA
6.Univ Michigan, Sch Med, Dept Epidemiol, Ann Arbor, MI USA
7.Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA
8.Univ Paris Diderot Sorbonne Paris, Hop Lariboisiere, AP HP, Paris, France
9.Yutian Cty Hosp, Dept Neurol, Tangshan, Hebei Province, Peoples R China
推荐引用方式
GB/T 7714
Sato, Shoichiro,Arima, Hisatomi,Heeley, Emma,et al. Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial[J]. CEREBROVASCULAR DISEASES,2015,40(3-4):114-120.
APA Sato, Shoichiro.,Arima, Hisatomi.,Heeley, Emma.,Hirakawa, Yoichiro.,Delcourt, Candice.,...&INTERACT2 Investigators.(2015).Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial.CEREBROVASCULAR DISEASES,40(3-4),114-120.
MLA Sato, Shoichiro,et al."Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial".CEREBROVASCULAR DISEASES 40.3-4(2015):114-120.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Sato, Shoichiro]的文章
[Arima, Hisatomi]的文章
[Heeley, Emma]的文章
百度学术
百度学术中相似的文章
[Sato, Shoichiro]的文章
[Arima, Hisatomi]的文章
[Heeley, Emma]的文章
必应学术
必应学术中相似的文章
[Sato, Shoichiro]的文章
[Arima, Hisatomi]的文章
[Heeley, Emma]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。