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学科主题: 临床医学
题名:
Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial
作者: Sato, Shoichiro1,2; Arima, Hisatomi1,2; Heeley, Emma1,2; Hirakawa, Yoichiro1,2; Delcourt, Candice1,2; Lindley, Richard I.1,2; Robinson, Thompson3; Huang, Yining4; Morgenstern, Lewis5,6,7; Stapf, Christian8; Wang, Jiguang9; Chalmers, John1,2; Anderson, Craig S.1,2; INTERACT2 Investigators
关键词: Intracerebral hemorrhage ; Hypertension ; Blood pressure ; Acute stroke care ; Clinical trials
刊名: CEREBROVASCULAR DISEASES
发表日期: 2015
DOI: 10.1159/000434690
卷: 40, 期:3-4, 页:114-120
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Peripheral Vascular Disease
研究领域[WOS]: Neurosciences & Neurology ; Cardiovascular System & Cardiology
关键词[WOS]: ISCHEMIC-STROKE ; CASE-FATALITY ; WEEKEND ; MORTALITY ; CARE ; ASSOCIATION ; COHORT ; TIME
英文摘要:

Background: Conflicting data exist of an association between off-hour (weekend, holiday, or night-time) hospital admission and adverse outcome in intracerebral hemorrhage (ICH). We determined the association between off-hour admissions and poor clinical outcome, and of any differential effect of early intensive blood pressure (BP) lowering treatment between off-and on-hour admissions, among participants of the Intensive BP Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Methods: Subsidiary analysis of INTERACT2, a multinational, multicenter, clinical trial of patients with spontaneous ICH with elevated systolic BP, randomly assigned to intensive (target systolic BP < 140 mm Hg) or guideline-based (< 180 mm Hg) BP management. Primary outcome was death or major disability (modified Rankin scale of 3-6) at 90 days. Off-hour admission was defined as night-time (4: 30 p.m. to 8: 30 a.m.) on weekdays, weekends (Saturday and Sunday), and public holidays in each participating country. Results: Of 2,794 patients with information on the primary outcome, 1,770 (63%) were admitted to study centers during off-hours. Off-hour admission was not associated with risk of poor outcome at 90 days (53% off-hour vs. 55% on-hour; p = 0.49), even after adjustment for comorbid risk factors (odds ratio 0.92; 95% CI 0.76-1.12). Consistency exists in the effects of intensive BP lowering between off-and on-hour admission (p = 0.85 for homogeneity). Conclusions: Off-hour admission was not associated with increased risks of death or major disability among trial protocol participants with acute ICH. Intensive BP lowering can provide similar treatment effect irrespective of admission hours. (C) 2015 S. Karger AG, Basel

语种: 英语
项目资助者: National Health and Medical Research Council of Australia
WOS记录号: WOS:000361496900003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65701
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.Univ Sydney, George Inst Global Hlth, Sydney, NSW 2006, Australia
2.Royal Prince Alfred Hosp, Sydney, NSW, Australia
3.Univ Leicester, NIHR Biomed Res Unit Cardiovasc Dis, Dept Cardiovasc Sci, Leicester, Leics, England
4.Peking Univ, Hosp 1, Dept Neurol, Beijing 100871, Peoples R China
5.Univ Michigan, Sch Med, Stroke Program, Ann Arbor, MI USA
6.Univ Michigan, Sch Med, Dept Epidemiol, Ann Arbor, MI USA
7.Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA
8.Univ Paris Diderot Sorbonne Paris, Hop Lariboisiere, AP HP, Paris, France
9.Yutian Cty Hosp, Dept Neurol, Tangshan, Hebei Province, Peoples R China

Recommended Citation:
Sato, Shoichiro,Arima, Hisatomi,Heeley, Emma,et al. Off-Hour Admission and Outcomes in Patients with Acute Intracerebral Hemorrhage in the INTERACT2 Trial[J]. CEREBROVASCULAR DISEASES,2015,40(3-4):114-120.
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