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Plasma S-100B protein in Chinese patients with schizophrenia: Comparison with healthy controls and effect of antipsychotics treatment
Ling, Si-hai; Tang, Yi-lang; Jiang, Feng; Wiste, Anna; Guo, Shi-shi; Weng, Yong-zhen; Yang, Tie-Sheng
关键词schizophrenia S-100B protein psychopathology PANSS
刊名JOURNAL OF PSYCHIATRIC RESEARCH
2007
DOI10.1016/j.jpsychires.2005.11.006
41期:1-2页:36-42
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]SOLUBLE INTERLEUKIN-2 RECEPTORS ; S100-BETA TRANSGENIC MICE ; NEURON-SPECIFIC ENOLASE ; SERUM S100B PROTEIN ; MAJOR DEPRESSION ; HEAD-INJURY ; PSYCHOSIS ; FAMILY ; BLOOD ; NEUROPATHOLOGY
英文摘要

Purpose: To examine the possibility that structural damage to the brain may play a role in the pathogenesis of schizophrenia by measuring the level of plasma S-100B, a calcium-binding protein found predominantly in the cytosol of glial cells. Method: Fifty-seven Chinese psychiatric inpatients who met DSM-IV diagnosis of schizophrenia and 60 healthy controls were enrolled in the study. Patients were assessed with the Positive and Negative Symptoms Scale (PANSS) at admission and at 12 weeks after treatment. Plasma samples were collected from patients and controls and S-100B protein was assayed using ELISA. Results: (1) 29 of 57 patients (50.9%) showed increased S-100B level compared to the mean level of 60 healthy controls (p < 0.005) vs. only 1 of 60 (1.67%) controls. The S-100B levels of unmedicated (0.119 +/- 0.059 mu g/L) and medicated patients (0.117 +/- 0.057 mu g/ L) were significantly higher than controls (0.067 +/- 0.022 mu g/L, both p < 0.001), and S-100B levels of unmedicated patients were higher than those of medicated patients (p = 0.024); (2) at admission, S-100B level was positively correlated with total score of PANSS (r = 0.269, p = 0.043), especially with negative subscore of PANSS (r = 0.306, p = 0.021), but the correlation was no longer present after patients were treated by anti-psychotic agents.

Conclusion: The S-100B levels of patients with schizophrenia are significantly higher than that of healthy controls, and the S-100B level is associated with severity of psychopathology, particularly negative symptoms, indicating that patients with schizophrenia may suffer structural damage to central nervous system. The concentration of S-100B may also be associated with treatment progress. (c) 2005 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000242709800006
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65720
专题北京大学第二临床医学院
作者单位1.Cent S Univ, Xiang Ya Med Coll, Changsha, Peoples R China
2.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
3.Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA
4.Capital Univ Med Sci, Beijing Anding Hosp, Beijing, Peoples R China
5.Emory Univ, Sch Med, Dept Psychiat & Behav Sci, Atlanta, GA 30322 USA
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GB/T 7714
Ling, Si-hai,Tang, Yi-lang,Jiang, Feng,et al. Plasma S-100B protein in Chinese patients with schizophrenia: Comparison with healthy controls and effect of antipsychotics treatment[J]. JOURNAL OF PSYCHIATRIC RESEARCH,2007,41(1-2):36-42.
APA Ling, Si-hai.,Tang, Yi-lang.,Jiang, Feng.,Wiste, Anna.,Guo, Shi-shi.,...&Yang, Tie-Sheng.(2007).Plasma S-100B protein in Chinese patients with schizophrenia: Comparison with healthy controls and effect of antipsychotics treatment.JOURNAL OF PSYCHIATRIC RESEARCH,41(1-2),36-42.
MLA Ling, Si-hai,et al."Plasma S-100B protein in Chinese patients with schizophrenia: Comparison with healthy controls and effect of antipsychotics treatment".JOURNAL OF PSYCHIATRIC RESEARCH 41.1-2(2007):36-42.
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