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Calibrated automated thrombography for monitoring coagulation function in patients with intracerebral haemorrhage
Yu, Yao1; Wu, Jun2; Zhao, Wei3; Zhao, Lei4; Zhu, Chunpeng3; Gao, Xuguang1
关键词Intracerebral haemorrhage thrombin calibrated automated thrombogram
刊名JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
2015-06-01
DOI10.1177/0300060514565801
43期:3页:316-325
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]ACTIVATED FACTOR-VII ; THROMBIN GENERATION ; CASE-FATALITY ; THERAPY
英文摘要

Objective To monitor coagulation function in patients with intracerebral haemorrhage (ICH) using calibrated automated thrombography.

Methods Patients admitted to hospital with ICH (confirmed within 18h of symptom onset) were enrolled. Patient history and blood samples were obtained within 6h of admission; further blood samples were collected on days 4, 8 and 15 (or on discharge between days 9-15: grouped with day 15 data). Blood samples were also collected from age- and sex-matched healthy controls. All samples underwent calibrated automated thrombography.

Results At admission, thrombin lag time and time to peak was longer, and endogenous thrombin potential and peak height were lower, in patients with ICH (n=20) than in healthy controls (n=29). Lag time in patients with ICH gradually decreased, but remained significantly longer than in controls until day 8. Time to peak also gradually decreased, but remained longer in patients than in controls by day 15. Endogenous thrombin potential and peak height gradually increased in patients, but remained lower than in controls on day 15.

Conclusions Patients with ICH have poorer coagulation function than healthy individuals, but this function gradually recovers during hospitalization.

语种英语
WOS记录号WOS:000354772600005
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65723
专题北京大学第二临床医学院_神经内科
北京大学基础医学院
北京大学第二临床医学院_检验科
作者单位1.Mancheng Cty Hosp, Dept Neurol, Baoding, Peoples R China
2.Peking Univ, Peoples Hosp, Med Lab, Beijing 100044, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China
4.Peking Univ, Jishuitan Hosp, Med Lab, Beijing 100044, Peoples R China
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GB/T 7714
Yu, Yao,Wu, Jun,Zhao, Wei,et al. Calibrated automated thrombography for monitoring coagulation function in patients with intracerebral haemorrhage[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2015,43(3):316-325.
APA Yu, Yao,Wu, Jun,Zhao, Wei,Zhao, Lei,Zhu, Chunpeng,&Gao, Xuguang.(2015).Calibrated automated thrombography for monitoring coagulation function in patients with intracerebral haemorrhage.JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,43(3),316-325.
MLA Yu, Yao,et al."Calibrated automated thrombography for monitoring coagulation function in patients with intracerebral haemorrhage".JOURNAL OF INTERNATIONAL MEDICAL RESEARCH 43.3(2015):316-325.
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