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学科主题: 临床医学
题名:
Calibrated automated thrombography for monitoring coagulation function in patients with intracerebral haemorrhage
作者: Yu, Yao1; Wu, Jun2; Zhao, Wei3; Zhao, Lei4; Zhu, Chunpeng3; Gao, Xuguang1
关键词: Intracerebral haemorrhage ; thrombin ; calibrated automated thrombogram
刊名: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
发表日期: 2015-06-01
DOI: 10.1177/0300060514565801
卷: 43, 期:3, 页:316-325
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: ACTIVATED FACTOR-VII ; THROMBIN GENERATION ; CASE-FATALITY ; THERAPY
英文摘要:

Objective To monitor coagulation function in patients with intracerebral haemorrhage (ICH) using calibrated automated thrombography.

Methods Patients admitted to hospital with ICH (confirmed within 18h of symptom onset) were enrolled. Patient history and blood samples were obtained within 6h of admission; further blood samples were collected on days 4, 8 and 15 (or on discharge between days 9-15: grouped with day 15 data). Blood samples were also collected from age- and sex-matched healthy controls. All samples underwent calibrated automated thrombography.

Results At admission, thrombin lag time and time to peak was longer, and endogenous thrombin potential and peak height were lower, in patients with ICH (n=20) than in healthy controls (n=29). Lag time in patients with ICH gradually decreased, but remained significantly longer than in controls until day 8. Time to peak also gradually decreased, but remained longer in patients than in controls by day 15. Endogenous thrombin potential and peak height gradually increased in patients, but remained lower than in controls on day 15.

Conclusions Patients with ICH have poorer coagulation function than healthy individuals, but this function gradually recovers during hospitalization.

语种: 英语
WOS记录号: WOS:000354772600005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65723
Appears in Collections:北京大学第二临床医学院_神经内科_期刊论文

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作者单位: 1.Mancheng Cty Hosp, Dept Neurol, Baoding, Peoples R China
2.Peking Univ, Peoples Hosp, Med Lab, Beijing 100044, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China
4.Peking Univ, Jishuitan Hosp, Med Lab, Beijing 100044, Peoples R China

Recommended Citation:
Yu, Yao,Wu, Jun,Zhao, Wei,et al. Calibrated automated thrombography for monitoring coagulation function in patients with intracerebral haemorrhage[J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH,2015,43(3):316-325.
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