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学科主题: 临床医学
题名:
Overview of lupus nephritis management guidelines and perspective from Asia
作者: Mok, Chi Chiu1; Yap, Desmond Y. H.2; Navarra, Sandra V.3; Liu, Zhi-Hong4; Zhao, Ming-Hui5; Lu, Liangjing6; Takeuchi, Tsutomu7; Avihingsanon, Yingyos8; Yu, Xue-Qing9; Lapid, Elizabeth A.3; Lugue-Lizardo, Lenrore R.3; Sumethkul, Vasant10; Shen, Nan6; Chen, Shun-Le6; Chan, Tak Mao2; ALNN
关键词: Asia ; lupus ; nephritis
刊名: NEPHROLOGY
发表日期: 2014
DOI: 10.1111/nep.12136
卷: 19, 期:1, 页:11-20
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: COATED MYCOPHENOLATE SODIUM ; RANDOMIZED CONTROLLED-TRIAL ; LONG-TERM ; INTRAVENOUS CYCLOPHOSPHAMIDE ; ORAL CYCLOPHOSPHAMIDE ; INDUCTION TREATMENT ; PULSE METHYLPREDNISOLONE ; ANGIOTENSIN INHIBITION ; MAINTENANCE THERAPY ; MOFETIL
英文摘要:

Lupus nephritis (LN) is a common and important manifestation of systemic lupus erythematosus (SLE). Evidence suggests higher rates of lupus renal involvement in Asian populations, and maybe more severe nephritis, compared with other racial or ethnic groups. The management of LN has evolved considerably over the past three decades, based on observations from clinical studies that investigated different immunosuppressive agents including corticosteroids, cyclophosphamide, azathioprine, mycophenolic acid, calcineurin inhibitors and novel biologic therapies. This is accompanied by improvements in both the short-term treatment response rate and long-term renal function preservation. Treatment guidelines for LN have recently been issued by rheumatology and nephrology communities in U.S.A. and Europe. In view of the racial difference in disease manifestation and response to therapy, and the substantial disease burden in Asia, a panel of 15 nephrologists and rheumatologists from different Asian regions with extensive experience in lupus nephritis - the Steering Group for the Asian Lupus Nephritis Network (ALNN) - met and discussed the management of lupus nephritis in Asian patients. The group has also reviewed and deliberated on the recently published recommendations from other parts of the world. This manuscript summarizes the discussions by the group and presents consensus views on the clinical management and treatment of adult Asian patients with LN, taking into account both the available evidence and expert opinion in areas where evidence remains to be sought.

语种: 英语
项目资助者: Wai Hung Charitable Foundation, Mr G. King ; Estate of the late Mr Chan Wing Hei ; Astellas Pharma Co. Hong Kong Ltd. ; Roche Hong Kong Ltd. ; Endowment Fund established for the &prime ; Yu Chiu Kwong Professorship in Medicine&prime ; at The University of Hong Kong
WOS记录号: WOS:000328573500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65726
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Renji Hosp, Dept Rheumatol, Shanghai, Peoples R China
2.Keio Univ, Sch Med, Div Rheumatol, Tokyo 108, Japan
3.Mahidol Univ, Div Nephrol, Bangkok 10700, Thailand
4.Jinling Hosp, Res Inst Nephrol, Nanjing, Peoples R China
5.Beijing Univ, Hosp 1, Renal Div, Beijing 100871, Peoples R China
6.Tuen Mun Hosp, Dept Med & Geriatr, Div Rheumatol, Hong Kong, Hong Kong, Peoples R China
7.Univ Hong Kong, Dept Med, Div Nephrol, Hong Kong, Hong Kong, Peoples R China
8.Univ Santo Tomas, St Lukes Med Ctr, Rheumatol Div, Manila, Philippines
9.Chulalongkorn Univ, Dept Med, Renal Div, Bangkok 10330, Thailand
10.Sun Yat Sen Univ, Hosp 1, Dept Nephrol, Guangzhou, Peoples R China

Recommended Citation:
Mok, Chi Chiu,Yap, Desmond Y. H.,Navarra, Sandra V.,et al. Overview of lupus nephritis management guidelines and perspective from Asia[J]. NEPHROLOGY,2014,19(1):11-20.
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