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IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Serial changes of mean platelet volume in relation to Killip Class in patients with acute myocardial infarction and primary percutaneous coronary intervention
作者: Wang, Xin-Yu1,2,3,4; Yu, Hai-Yi1,2,3,4; Zhang, You-Yi1,2,3,4; Wang, Yu-Peng1,2,3,4; Feng, Xin-Heng1,2,3,4; Li, Zhao-Ping1,2,3,4; Du, Xiao-Jun5,6; Gao, Wei1,2,3,4
关键词: Mean platelet volume ; Acute myocardial infarction ; Killip Class ; Primary percutaneous coronary intervention ; Clopidogrel
刊名: THROMBOSIS RESEARCH
发表日期: 2015-04-01
DOI: 10.1016/j.thromres.2015.01.033
卷: 135, 期:4, 页:652-658
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: ARTERY-DISEASE ; HEART-FAILURE ; INDEXES ; SIZE ; SUBPOPULATIONS ; ASSOCIATION ; ACTIVATION ; RANGE ; RISK
英文摘要:

Introduction: Mean platelet volume (MPV) is related to the reactivity of platelets. Among survivors of acute myocardial infarction (MI), greater MPV is known to be associated with impaired reperfusion and higher mortality. The aims of the study is to investigate the dynamic changes of MPV and the relation between MPV and cardiac function in patients with acute MI and received primary percutaneous coronary intervention (PCI).

Materials and Methods: This retrospective cohort study included patients presented during January 2008 to March 2011 to Peking University Third Hospital with ST-segment elevation MI. All patients received successful PCI. MPV was measured serially, using a Sysmex XE2100 haematology analyser, from admission to day-7 after MI.

Results: In 375 patients, MPV was at its highest value (10.2 +/- 1.0 fL) and correlated well with platelet distribution width (PDW, r=0.833, p < 0.0001) at the admission, and then reduced by 16% within the 24 hours, together with marked weakening of its correlation with PDW. Patients with poorer ventricular function, estimated by high Killip Class (>= 2, n = 96), had higher MPV values at all-time points. By logistic regression model and after adjusting for related confounders, high MPV remained as an independent predictor of Killip Class = 2 (OR 1.873, CI 95% 1.373 - 2.673, p = 0.001). Clopidogrel pre-usage resulted in significant MPV reduction on admission.

Conclusions: MPV undergoes rapid and dynamic changes during the acute phase of MI, and was higher in patients with high Killip Class, suggesting a predictive value of MPV in ventricular dysfunction and clinical outcome of acute phase of MI. (C) 2015 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 30910103902 ; 81370317 ; 7144254
项目资助者: Projects of International Cooperation and Exchanges NSFC ; National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000351086000015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65728
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Sci, Beijing, Peoples R China
2.Beijing Key Lab Cardiovasc Receptors Res, Beijing, Peoples R China
3.Monash Univ, Cent Clin Sch, Melbourne, Vic 3004, Australia
4.Peking Univ, Dept Cardiol, Inst Vasc Med, Hosp 3, Beijing 100191, Peoples R China
5.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing, Peoples R China
6.Baker IDI Heart Diabet Inst, Melbourne, Vic 3004, Australia

Recommended Citation:
Wang, Xin-Yu,Yu, Hai-Yi,Zhang, You-Yi,et al. Serial changes of mean platelet volume in relation to Killip Class in patients with acute myocardial infarction and primary percutaneous coronary intervention[J]. THROMBOSIS RESEARCH,2015,135(4):652-658.
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