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学科主题: 临床医学
题名:
Renal Neutrophils Infiltration in Antineutrophil Cytoplasmic Antibodies-Negative Pauci-Immune Crescentic Glomerulonephritis
作者: Xing, Guang-qun1,2,3,4; Chen, Min1,2,3; Liu, Gang1,2,3; Wang, Su-xia1,2,3; Zhao, Ming-hui1,2,3
关键词: ANCA-negative ; Crescentic glomerulonephritis ; Neutrophil ; Pauci-immune
刊名: AMERICAN JOURNAL OF THE MEDICAL SCIENCES
发表日期: 2010-12-01
DOI: 10.1097/MAJ.0b013e3181f0768e
卷: 340, 期:6, 页:474-480
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: ANCA-ASSOCIATED VASCULITIS ; AUTOANTIBODIES ; MYELOPEROXIDASE ; INVOLVEMENT ; NEPHRITIS ; HISTOLOGY
英文摘要:

Introduction: This study aims to investigate the evidence of neutrophil infiltration in renal tissue from patients with antineutrophil cytoplasmic antibodies (ANCA)-negative pauci-immune crescentic glomerulonephritis (CrGN), and a comparison with their ANCA-positive counterparts was performed. Methods: Renal biopsy specimens from 31 patients with pauci-immune CrGN were collected. Twelve patients were ANCA negative, and 19 patients were ANCA positive. Neutrophil infiltration was investigated by staining of 2 markers, CD15 and myeloperoxidase (MPO), using immunohistochemistry. Results: Positive-stained cells of CD15 (CD15(+)) and MPO (MPO+) were mainly located in glomeruli with cellular crescents and segmental fibrinoid necrotic lesions and in periglomerular area of cellular crescents, especially at the area of ruptured Bowman capsule. Scanty positive staining was found in normal renal tissue. The number of CD15(+) cells in the glomeruli and periglomerular area was significantly higher in ANCA-negative group than in ANCA-positive group (in glomeruli: 2.70 +/- 1.61 versus 1.38 +/- 0.85, P = 0.019; in periglomerular area: 4.35 +/- 4.36 versus 1.48 +/- 1.67, P = 0.047). The number of MPO+ cells in the periglomerular area was also significantly higher in ANCA-negative group than that in ANCA-positive group. Conclusions: Renal neutrophil infiltration might play a pathogenic role in ANCA-negative pauci-immune CrGN, and the neutrophil infiltration might be more severe in ANCA-negative pauci-immune CrGN than in ANCA-positive one.

语种: 英语
所属项目编号: 30725034 ; 30972733
项目资助者: National Science Fund for Distinguished Young Scholars ; National Natural Science grant
WOS记录号: WOS:000284821500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65737
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Div Renal, Dept Med, Beijing 100034, Peoples R China
4.Qingdao Univ, Div Renal, Dept Med, Affiliated Hosp,Med Coll, Qingdao 266071, Peoples R China

Recommended Citation:
Xing, Guang-qun,Chen, Min,Liu, Gang,et al. Renal Neutrophils Infiltration in Antineutrophil Cytoplasmic Antibodies-Negative Pauci-Immune Crescentic Glomerulonephritis[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2010,340(6):474-480.
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