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Renal Neutrophils Infiltration in Antineutrophil Cytoplasmic Antibodies-Negative Pauci-Immune Crescentic Glomerulonephritis
Xing, Guang-qun1,2,3,4; Chen, Min1,2,3; Liu, Gang1,2,3; Wang, Su-xia1,2,3; Zhao, Ming-hui1,2,3
关键词ANCA-negative Crescentic glomerulonephritis Neutrophil Pauci-immune
刊名AMERICAN JOURNAL OF THE MEDICAL SCIENCES
2010-12-01
DOI10.1097/MAJ.0b013e3181f0768e
340期:6页:474-480
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]ANCA-ASSOCIATED VASCULITIS ; AUTOANTIBODIES ; MYELOPEROXIDASE ; INVOLVEMENT ; NEPHRITIS ; HISTOLOGY
英文摘要

Introduction: This study aims to investigate the evidence of neutrophil infiltration in renal tissue from patients with antineutrophil cytoplasmic antibodies (ANCA)-negative pauci-immune crescentic glomerulonephritis (CrGN), and a comparison with their ANCA-positive counterparts was performed. Methods: Renal biopsy specimens from 31 patients with pauci-immune CrGN were collected. Twelve patients were ANCA negative, and 19 patients were ANCA positive. Neutrophil infiltration was investigated by staining of 2 markers, CD15 and myeloperoxidase (MPO), using immunohistochemistry. Results: Positive-stained cells of CD15 (CD15(+)) and MPO (MPO+) were mainly located in glomeruli with cellular crescents and segmental fibrinoid necrotic lesions and in periglomerular area of cellular crescents, especially at the area of ruptured Bowman capsule. Scanty positive staining was found in normal renal tissue. The number of CD15(+) cells in the glomeruli and periglomerular area was significantly higher in ANCA-negative group than in ANCA-positive group (in glomeruli: 2.70 +/- 1.61 versus 1.38 +/- 0.85, P = 0.019; in periglomerular area: 4.35 +/- 4.36 versus 1.48 +/- 1.67, P = 0.047). The number of MPO+ cells in the periglomerular area was also significantly higher in ANCA-negative group than that in ANCA-positive group. Conclusions: Renal neutrophil infiltration might play a pathogenic role in ANCA-negative pauci-immune CrGN, and the neutrophil infiltration might be more severe in ANCA-negative pauci-immune CrGN than in ANCA-positive one.

语种英语
WOS记录号WOS:000284821500009
项目编号30725034 ; 30972733
资助机构National Science Fund for Distinguished Young Scholars ; National Natural Science grant
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65737
专题北京大学第一临床医学院_肾脏内科
北京大学第一临床医学院_电镜室
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Div Renal, Dept Med, Beijing 100034, Peoples R China
4.Qingdao Univ, Div Renal, Dept Med, Affiliated Hosp,Med Coll, Qingdao 266071, Peoples R China
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GB/T 7714
Xing, Guang-qun,Chen, Min,Liu, Gang,et al. Renal Neutrophils Infiltration in Antineutrophil Cytoplasmic Antibodies-Negative Pauci-Immune Crescentic Glomerulonephritis[J]. AMERICAN JOURNAL OF THE MEDICAL SCIENCES,2010,340(6):474-480.
APA Xing, Guang-qun,Chen, Min,Liu, Gang,Wang, Su-xia,&Zhao, Ming-hui.(2010).Renal Neutrophils Infiltration in Antineutrophil Cytoplasmic Antibodies-Negative Pauci-Immune Crescentic Glomerulonephritis.AMERICAN JOURNAL OF THE MEDICAL SCIENCES,340(6),474-480.
MLA Xing, Guang-qun,et al."Renal Neutrophils Infiltration in Antineutrophil Cytoplasmic Antibodies-Negative Pauci-Immune Crescentic Glomerulonephritis".AMERICAN JOURNAL OF THE MEDICAL SCIENCES 340.6(2010):474-480.
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