IR@PKUHSC  > 北京大学药学院
学科主题药学
Effect of synthetic oligopeptides on osteoporosis
Cui, W; Wang, C; Zhao, M; Peng, SQ
刊名PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
2002
DOI10.1080/PB-120013472
32期:3页:253-268
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
研究领域[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology
关键词[WOS]HORMONE ; HEXAPEPTIDE ; SECRETION
英文摘要

The objective of this study was to establish the solution method of GHRPS, the synthetic oligopeptides Tyr-Gly-Gly-Phe-Met-NH2, Tyr-Gly-Gly- Phe-Met-OH, Tyr-Gly-Gly-Phe-Leu-NH2, Tyr-Gly-Gly-Phe-Leu-OH, Tyr-Gly-Gly-Phe-Gly-NH2, and Tyr-Gly-Gly-Phe -Gly-OH, to verify their effect on osteoporosis. Male ICR mice (20 +/- 2 g) were used. The intramuscular injection dose of 6.3 mg/kg prednisone induced a significant decrease of body and femur weight of the animals. The subcutaneous injection dose. of 18 mug/kg synthetic peptide was not effective to prevent the decrease of body and femur weight of the animals. The subcutaneous injection dose of 6.3 mg/kg prednisone elicited a decrease in content of femur calcium and in the level of serum calcium of the animals. The subcutaneous injection dose of 18 mug/kg Tyr-Gly-Gly-Phe-Leu-NH2, or Tyr-Gly-Gly-Phe-Leu-OH, or Tyr-Gly-Gly-Phe-Gly-NH2 significantly increased the content of femur calcium and decreased the level of serum calcium of the animals. It was also observed that the subcutaneous injection dose of 18 mug/kg Tyr-Gly-Gly-Phe-Gly-OH, Tyr-Gly-Gly-Phe-Leu-OH, Tyr-Gly-Gly-Phe-Met-OH, Tyr-Gly-Gly-Phe-Met-NH2 significantly increased the content of femur phosphorous and decreased the activity of ALP of the animals.

语种英语
WOS记录号WOS:000178535000003
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65739
Collection北京大学药学院
作者单位Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Cui, W,Wang, C,Zhao, M,et al. Effect of synthetic oligopeptides on osteoporosis[J]. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY,2002,32(3):253-268.
APA Cui, W,Wang, C,Zhao, M,&Peng, SQ.(2002).Effect of synthetic oligopeptides on osteoporosis.PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY,32(3),253-268.
MLA Cui, W,et al."Effect of synthetic oligopeptides on osteoporosis".PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY 32.3(2002):253-268.
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