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学科主题临床医学
Role of substance P in viral myocarditis in mice
Wang, Yong1,2; Shimada, Miho1; Xu, Yawei2; Hu, Dayi3; Nishio, Ryosuke4; Matsumori, Akira1
关键词Substance P Viral myocarditis Encephalomyocarditis virus Mast cell
刊名HEART AND VESSELS
2010-07-01
DOI10.1007/s00380-009-1189-3
25期:4页:348-352
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]GUINEA-PIG HEART ; IMMUNOREACTIVE NERVES ; DILATED CARDIOMYOPATHY ; PEPTIDE ; FAILURE ; NEUROPEPTIDE ; INFLAMMATION ; NEUROTENSIN ; TACHYKININS ; INNERVATION
英文摘要

Substance P (SP) is widely expressed in the central nervous system and in peripheral tissues such as myocardial nerves. We examined SP in viral myocarditis in mice induced by encephalomyocarditis virus (EMCV). Localization of SP in the hearts was examined immunohistochemically, and concentrations of SP in hearts and sera were measured by enzyme immunoassay. Substance P levels and density of SP-containing cells in murine hearts on day 6 after EMCV inoculation were decreased compared with those in normal controls. There was a negative correlation between SP levels in the hearts and ratio of heart weight to body weight of the mice at 6 days. Circulating SP levels were decreased in mice on day 6 after EMCV inoculation, and further decreased on day 14. Substance P in hearts and sera is decreased in viral myocarditis in mice, suggesting that SP may play a role in the pathogenesis of viral myocarditis, and that interaction of the neuropeptide nervous system and mast-cell immune system is important in the pathogenesis of viral myocarditis.

语种英语
WOS记录号WOS:000280477500012
资助机构Japanese Ministry of Health, Labour and Welfare ; Japanese Ministry of Education, Culture, Sports, Science, and Technology
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65740
专题北京大学第二临床医学院_心血管内科
作者单位1.Tongji Univ, Peoples Hosp 10, Shanghai, Peoples R China
2.Kyoto Univ Hosp, Div Emergency Med, Kyoto 606, Japan
3.Kyoto Univ, Dept Cardiovasc Med, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
4.Peking Univ, Dept Cardiol, Peoples Hosp, Beijing 100871, Peoples R China
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GB/T 7714
Wang, Yong,Shimada, Miho,Xu, Yawei,et al. Role of substance P in viral myocarditis in mice[J]. HEART AND VESSELS,2010,25(4):348-352.
APA Wang, Yong,Shimada, Miho,Xu, Yawei,Hu, Dayi,Nishio, Ryosuke,&Matsumori, Akira.(2010).Role of substance P in viral myocarditis in mice.HEART AND VESSELS,25(4),348-352.
MLA Wang, Yong,et al."Role of substance P in viral myocarditis in mice".HEART AND VESSELS 25.4(2010):348-352.
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