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学科主题: 临床医学
题名:
Role of substance P in viral myocarditis in mice
作者: Wang, Yong1,2; Shimada, Miho1; Xu, Yawei2; Hu, Dayi3; Nishio, Ryosuke4; Matsumori, Akira1
关键词: Substance P ; Viral myocarditis ; Encephalomyocarditis virus ; Mast cell
刊名: HEART AND VESSELS
发表日期: 2010-07-01
DOI: 10.1007/s00380-009-1189-3
卷: 25, 期:4, 页:348-352
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems ; Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: GUINEA-PIG HEART ; IMMUNOREACTIVE NERVES ; DILATED CARDIOMYOPATHY ; PEPTIDE ; FAILURE ; NEUROPEPTIDE ; INFLAMMATION ; NEUROTENSIN ; TACHYKININS ; INNERVATION
英文摘要:

Substance P (SP) is widely expressed in the central nervous system and in peripheral tissues such as myocardial nerves. We examined SP in viral myocarditis in mice induced by encephalomyocarditis virus (EMCV). Localization of SP in the hearts was examined immunohistochemically, and concentrations of SP in hearts and sera were measured by enzyme immunoassay. Substance P levels and density of SP-containing cells in murine hearts on day 6 after EMCV inoculation were decreased compared with those in normal controls. There was a negative correlation between SP levels in the hearts and ratio of heart weight to body weight of the mice at 6 days. Circulating SP levels were decreased in mice on day 6 after EMCV inoculation, and further decreased on day 14. Substance P in hearts and sera is decreased in viral myocarditis in mice, suggesting that SP may play a role in the pathogenesis of viral myocarditis, and that interaction of the neuropeptide nervous system and mast-cell immune system is important in the pathogenesis of viral myocarditis.

语种: 英语
项目资助者: Japanese Ministry of Health, Labour and Welfare ; Japanese Ministry of Education, Culture, Sports, Science, and Technology
WOS记录号: WOS:000280477500012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65740
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Tongji Univ, Peoples Hosp 10, Shanghai, Peoples R China
2.Kyoto Univ Hosp, Div Emergency Med, Kyoto 606, Japan
3.Kyoto Univ, Dept Cardiovasc Med, Grad Sch Med, Sakyo Ku, Kyoto 6068507, Japan
4.Peking Univ, Dept Cardiol, Peoples Hosp, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Yong,Shimada, Miho,Xu, Yawei,et al. Role of substance P in viral myocarditis in mice[J]. HEART AND VESSELS,2010,25(4):348-352.
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