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学科主题临床医学
Comparison of immune manifestations between refractory cytopenia of childhood and aplastic anemia in children: A single-center retrospective study
Wu, Jun; Cheng, Yifei; Zhang, Leping
关键词Immune manifestation Children Refractory cytopenia Aplastic anemia
刊名LEUKEMIA RESEARCH
2015-12-01
DOI10.1016/j.leukres.2015.09.012
39期:12页:1347-1352
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]NATURAL-KILLER-CELLS ; MYELODYSPLASTIC SYNDROME ; BONE-MARROW ; IMMUNOLOGICAL ABNORMALITIES ; IMMUNOSUPPRESSIVE THERAPY ; AUTOIMMUNE PHENOMENA ; FREQUENTLY OCCURS ; T-CELLS ; MDS ; EXPRESSION
英文摘要

This retrospective single-center study assessed the incidence and clinical features of immune manifestations of refractory cytopenia of childhood (RCC) and childhood aplastic anemia (AA). We evaluated 72 children with RCC and 123 with AA between February 2008 and March 2013. RCC was associated with autoimmune disease in 4 children, including 1 case each with autoimmune hemolytic anemia, rheumatoid arthritis, systemic lupus erythematosus, and anaphylactoid purpura. No children with AA were diagnosed with autoimmune diseases. Immune abnormalities were common in both RCC and AA; the most significant reductions were in the relative numbers of CD3 CD56+ subsets found in RCC. Despite the many similar immunologic abnormalities in AA and RCC, the rate of autoimmune disease was significantly lower in childhood AA than RCC (p = 0.008, chi(2) = 6.976). The relative numbers of natural killer cells were significantly lower in RCC patients than AA patients. By month 6, there was no significant difference in autoimmune manifestations between RCC and AA in relation to the response to immunosuppressive therapy (p = 0.907, chi(2) = 0.014). The large overlap of analogous immunologic abnormalities indicates that RCC and childhood AA may share the same pathogenesis. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000365335200007
项目编号81100339
资助机构National Natural Science Fund Committee of China
引用统计
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65742
专题北京大学第二临床医学院_儿科
作者单位Peking Univ, Affiliated Peoples Hosp, Dept Pediat, Sch Med, Beijing 100044, Peoples R China
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Wu, Jun,Cheng, Yifei,Zhang, Leping. Comparison of immune manifestations between refractory cytopenia of childhood and aplastic anemia in children: A single-center retrospective study[J]. LEUKEMIA RESEARCH,2015,39(12):1347-1352.
APA Wu, Jun,Cheng, Yifei,&Zhang, Leping.(2015).Comparison of immune manifestations between refractory cytopenia of childhood and aplastic anemia in children: A single-center retrospective study.LEUKEMIA RESEARCH,39(12),1347-1352.
MLA Wu, Jun,et al."Comparison of immune manifestations between refractory cytopenia of childhood and aplastic anemia in children: A single-center retrospective study".LEUKEMIA RESEARCH 39.12(2015):1347-1352.
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