北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 儿科  > 期刊论文
学科主题: 临床医学
题名:
Comparison of immune manifestations between refractory cytopenia of childhood and aplastic anemia in children: A single-center retrospective study
作者: Wu, Jun; Cheng, Yifei; Zhang, Leping
关键词: Immune manifestation ; Children ; Refractory cytopenia ; Aplastic anemia
刊名: LEUKEMIA RESEARCH
发表日期: 2015-12-01
DOI: 10.1016/j.leukres.2015.09.012
卷: 39, 期:12, 页:1347-1352
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: NATURAL-KILLER-CELLS ; MYELODYSPLASTIC SYNDROME ; BONE-MARROW ; IMMUNOLOGICAL ABNORMALITIES ; IMMUNOSUPPRESSIVE THERAPY ; AUTOIMMUNE PHENOMENA ; FREQUENTLY OCCURS ; T-CELLS ; MDS ; EXPRESSION
英文摘要:

This retrospective single-center study assessed the incidence and clinical features of immune manifestations of refractory cytopenia of childhood (RCC) and childhood aplastic anemia (AA). We evaluated 72 children with RCC and 123 with AA between February 2008 and March 2013. RCC was associated with autoimmune disease in 4 children, including 1 case each with autoimmune hemolytic anemia, rheumatoid arthritis, systemic lupus erythematosus, and anaphylactoid purpura. No children with AA were diagnosed with autoimmune diseases. Immune abnormalities were common in both RCC and AA; the most significant reductions were in the relative numbers of CD3 CD56+ subsets found in RCC. Despite the many similar immunologic abnormalities in AA and RCC, the rate of autoimmune disease was significantly lower in childhood AA than RCC (p = 0.008, chi(2) = 6.976). The relative numbers of natural killer cells were significantly lower in RCC patients than AA patients. By month 6, there was no significant difference in autoimmune manifestations between RCC and AA in relation to the response to immunosuppressive therapy (p = 0.907, chi(2) = 0.014). The large overlap of analogous immunologic abnormalities indicates that RCC and childhood AA may share the same pathogenesis. (C) 2015 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81100339
项目资助者: National Natural Science Fund Committee of China
WOS记录号: WOS:000365335200007
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65742
Appears in Collections:北京大学第二临床医学院_儿科_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
1-s2.0-S0145212615303830-main.pdf(495KB)期刊论文作者接受稿限制开放 联系获取全文

作者单位: Peking Univ, Affiliated Peoples Hosp, Dept Pediat, Sch Med, Beijing 100044, Peoples R China

Recommended Citation:
Wu, Jun,Cheng, Yifei,Zhang, Leping. Comparison of immune manifestations between refractory cytopenia of childhood and aplastic anemia in children: A single-center retrospective study[J]. LEUKEMIA RESEARCH,2015,39(12):1347-1352.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wu, Jun]'s Articles
[Cheng, Yifei]'s Articles
[Zhang, Leping]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wu, Jun]‘s Articles
[Cheng, Yifei]‘s Articles
[Zhang, Leping]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace