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学科主题临床医学
Gene polymorphism of platelet glycoprotein I b alpha in Chinese patients with large- and small-artery subtypes of ischemic stroke
Gao, XG; Huo, Y; Liu, XZ; Teng, ZP
关键词ischemic stroke platelet glycoprotein I b alpha polymorphism human platelet antigen 2
刊名EUROPEAN NEUROLOGY
2005
DOI10.1159/000087716
54期:2页:73-77
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]VON-WILLEBRAND-FACTOR ; VONWILLEBRAND-FACTOR ; THROMBUS FORMATION ; INCREASED RISK ; SHEAR-STRESS ; ASSOCIATION ; AGGREGATION ; DISEASE ; TRIAL ; HPA-2
英文摘要

The platelet surface glycoprotein (GP) I b alpha, an important part of the GP I b-IX-V complex, participates in the formation of thrombosis by initially mediating platelet adhesion under high shear stress. The purpose of present study was to investigate the association between gene polymorphism of GP I b alpha ( human platelet antigen 2, HPA2) and ischemic stroke in a matched case-control study. One hundred patients and 100 matched controls were enrolled in the study. The cases were divided into large- and small-vessel subtypes of ischemic stroke according to Trial of Org10172 in Acute Stroke Treatment criteria. Genotyping for GP I b alpha polymorphism was documented by polymerase chain reaction amplifi cation and restriction enzyme analysis. There were no statistically significant differences in the GP I b alpha HPA2 genotype distribution between ischemic stroke group, large- vessel subtype group, small-vessel subtype group and corresponding control groups. The heterozygote genotype of GP I b alpha HPA2 was more frequent in the large- vessel subtype group (16.1%) than in the small-vessel subtype group (10.1%), but the difference was not statistically significant. Our results suggest that the polymorphism of the GP I b alpha HPA2 genotype might not be a genetic risk factor of ischemic stroke. Copyright (C) 2005 S. Karger AG, Basel.

语种英语
WOS记录号WOS:000232876400003
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65757
专题北京大学第二临床医学院_神经内科
作者单位1.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Gao, XG,Huo, Y,Liu, XZ,et al. Gene polymorphism of platelet glycoprotein I b alpha in Chinese patients with large- and small-artery subtypes of ischemic stroke[J]. EUROPEAN NEUROLOGY,2005,54(2):73-77.
APA Gao, XG,Huo, Y,Liu, XZ,&Teng, ZP.(2005).Gene polymorphism of platelet glycoprotein I b alpha in Chinese patients with large- and small-artery subtypes of ischemic stroke.EUROPEAN NEUROLOGY,54(2),73-77.
MLA Gao, XG,et al."Gene polymorphism of platelet glycoprotein I b alpha in Chinese patients with large- and small-artery subtypes of ischemic stroke".EUROPEAN NEUROLOGY 54.2(2005):73-77.
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