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学科主题临床医学
Effects of proton-pump inhibitors on functional dyspepsia: A meta-analysis of randomized placebo-controlled trials
Wang, Wei Hong; Huang, Jia Qing; Zheng, Ge Fan; Xia, Harry H. X.; Wong, Wai Man; Liu, Xin Guang; Karlberg, Johan; Wong, Benjamin C. Y.
刊名CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
2007-02-01
DOI10.1016/j.cgh.2006.09.012
5期:2页:178-185
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]GASTROESOPHAGEAL-REFLUX DISEASE ; ACID-RELATED DYSPEPSIA ; STARTING-DAY TRIAL ; HEALTH-CARE CONSUMPTION ; LOW-DOSE LANSOPRAZOLE ; QUALITY-OF-LIFE ; NONULCER DYSPEPSIA ; DOUBLE-BLIND ; GENERAL-PRACTICE ; HELICOBACTER-PYLORI
英文摘要

Background & Aims: The aim of this study was to assess systematically the efficacy of proton pump inhibitors (PPIs) in the treatment of functional dyspepsia compared with placebo and to determine if any difference in the response exists between symptom subgroups of functional dyspepsia. Methods: A literature search was performed through September 2005 in PubMed, Medline, Embase, CINAHL, and Cochrane databases to include randomized, double-blind, placebo-controlled trials evaluating the efficacy of PPIs for the treatment of functional dyspepsia. Relative risk (RR) and relative risk reduction (RRR) and 95% confidence intervals (CI) were calculated under a random-effects model. Results: Seven studies with a total of 3725 patients were identified. PPIs were found to be more effective than placebo for reducing symptoms in patients with functional dyspepsia (RRR, 10.3%; 95% C1, 2.7%-17.3%). The estimated number needed to treat is 14.6 (95% CI, 8.7-57.1). When stratified analyses were performed, a significant difference in the efficacy was observed only in patients with ulcer-like (RRR, 12.8%; 95% CI, 7.2%-18.1%) and reflux-like dyspepsia (RRR, 19.7%; 95% CI, 1.8%-34.3%), but not in those with dysmotility-like (RRR, 5.1%; 95% CI, -10.9% to 18.7%) and unspecified dyspepsia (RRR, -8.0%; 95% CI, -23.7% to 5.6%). The effect of H pylori on the efficacy of PPIs remains unclear. Significant heterogeneity among studies was found for the overall analysis, dysmotility-like dyspepsia, H pylori-negative subgroup, and different dose subgroups. Conclusions: PPIs are more effective than placebo for the management of patients with ulcer-like and reflux-like functional dyspepsia.

语种英语
WOS记录号WOS:000244511700010
引用统计
被引频次:69[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65758
专题北京大学第一临床医学院_消化科
作者单位1.Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100871, Peoples R China
2.Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China
3.Univ Hong Kong, Clin Trials Ctr, Fac Med, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Wang, Wei Hong,Huang, Jia Qing,Zheng, Ge Fan,et al. Effects of proton-pump inhibitors on functional dyspepsia: A meta-analysis of randomized placebo-controlled trials[J]. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY,2007,5(2):178-185.
APA Wang, Wei Hong.,Huang, Jia Qing.,Zheng, Ge Fan.,Xia, Harry H. X..,Wong, Wai Man.,...&Wong, Benjamin C. Y..(2007).Effects of proton-pump inhibitors on functional dyspepsia: A meta-analysis of randomized placebo-controlled trials.CLINICAL GASTROENTEROLOGY AND HEPATOLOGY,5(2),178-185.
MLA Wang, Wei Hong,et al."Effects of proton-pump inhibitors on functional dyspepsia: A meta-analysis of randomized placebo-controlled trials".CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 5.2(2007):178-185.
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