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学科主题: 临床医学
题名:
Effects of proton-pump inhibitors on functional dyspepsia: A meta-analysis of randomized placebo-controlled trials
作者: Wang, Wei Hong; Huang, Jia Qing; Zheng, Ge Fan; Xia, Harry H. X.; Wong, Wai Man; Liu, Xin Guang; Karlberg, Johan; Wong, Benjamin C. Y.
刊名: CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
发表日期: 2007-02-01
DOI: 10.1016/j.cgh.2006.09.012
卷: 5, 期:2, 页:178-185
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: GASTROESOPHAGEAL-REFLUX DISEASE ; ACID-RELATED DYSPEPSIA ; STARTING-DAY TRIAL ; HEALTH-CARE CONSUMPTION ; LOW-DOSE LANSOPRAZOLE ; QUALITY-OF-LIFE ; NONULCER DYSPEPSIA ; DOUBLE-BLIND ; GENERAL-PRACTICE ; HELICOBACTER-PYLORI
英文摘要:

Background & Aims: The aim of this study was to assess systematically the efficacy of proton pump inhibitors (PPIs) in the treatment of functional dyspepsia compared with placebo and to determine if any difference in the response exists between symptom subgroups of functional dyspepsia. Methods: A literature search was performed through September 2005 in PubMed, Medline, Embase, CINAHL, and Cochrane databases to include randomized, double-blind, placebo-controlled trials evaluating the efficacy of PPIs for the treatment of functional dyspepsia. Relative risk (RR) and relative risk reduction (RRR) and 95% confidence intervals (CI) were calculated under a random-effects model. Results: Seven studies with a total of 3725 patients were identified. PPIs were found to be more effective than placebo for reducing symptoms in patients with functional dyspepsia (RRR, 10.3%; 95% C1, 2.7%-17.3%). The estimated number needed to treat is 14.6 (95% CI, 8.7-57.1). When stratified analyses were performed, a significant difference in the efficacy was observed only in patients with ulcer-like (RRR, 12.8%; 95% CI, 7.2%-18.1%) and reflux-like dyspepsia (RRR, 19.7%; 95% CI, 1.8%-34.3%), but not in those with dysmotility-like (RRR, 5.1%; 95% CI, -10.9% to 18.7%) and unspecified dyspepsia (RRR, -8.0%; 95% CI, -23.7% to 5.6%). The effect of H pylori on the efficacy of PPIs remains unclear. Significant heterogeneity among studies was found for the overall analysis, dysmotility-like dyspepsia, H pylori-negative subgroup, and different dose subgroups. Conclusions: PPIs are more effective than placebo for the management of patients with ulcer-like and reflux-like functional dyspepsia.

语种: 英语
WOS记录号: WOS:000244511700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65758
Appears in Collections:北京大学第一临床医学院_消化内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100871, Peoples R China
2.Univ Hong Kong, Dept Med, Hong Kong, Hong Kong, Peoples R China
3.Univ Hong Kong, Clin Trials Ctr, Fac Med, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Wang, Wei Hong,Huang, Jia Qing,Zheng, Ge Fan,et al. Effects of proton-pump inhibitors on functional dyspepsia: A meta-analysis of randomized placebo-controlled trials[J]. CLINICAL GASTROENTEROLOGY AND HEPATOLOGY,2007,5(2):178-185.
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