IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Hippocampal Nerve Growth Factor Potentiated by 17 beta-Estradiol and Involved in Allodynia of Inflamed TMJ in Rat
Wu, Yu-Wei1; Kou, Xiao-Xing1; Bi, Rui-Yun1; Xu, Wen2,3; Wang, Ke-Wei2,3; Gan, Ye-Hua1; Ma, Xu-Chen1
关键词Estrogen nerve growth factor (NGF) temporomandibular disorder (TMD) pain hippocampus
刊名JOURNAL OF PAIN
2012-06-01
DOI10.1016/j.jpain.2012.03.005
13期:6页:555-563
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]TEMPOROMANDIBULAR-JOINT INFLAMMATION ; C-FOS EXPRESSION ; MESSENGER-RNA ; FEMALE RATS ; INTRACEREBROVENTRICULAR INFUSION ; SPINOMEDULLARY JUNCTION ; NEUROTROPHIN RECEPTORS ; OVARIECTOMIZED RATS ; CEREBROSPINAL-FLUID ; ALZHEIMERS-DISEASE
英文摘要

The hippocampus is believed to play an important role in sex-based differences of pain perception. Whether estrogen potentiates allodynia in the inflamed temporomandibular joint (TMJ) through affecting the expressions of pain-related genes in the hippocampus remains largely unknown. Because the nerve growth factor (NGF) is an important gene related to inflammatory pain, we tested whether hippocampal NGF may be involved in TMJ inflammatory pain. Here we showed that the rat hippocampal NGF was upregulated by TMJ inflammation induced by complete Freund adjuvant. NGF upregulation was further potentiated by estradiol in a dose-dependent manner. In contrast, NGF transcription in the amygdala, prefrontal cortex, and thalamus was not affected by TMJ inflammation and estradiol. An intrahippocampal injection of NGF antibody or NGF receptor inhibitor K252a (inhibitor for tropomyosin receptor kinase A, TrkA) reduced the allodynia of inflamed TMJ in proestrous rats. Our data suggest that the hippocampal NGF is involved in estradiol-sensitized allodynia of inflammatory TMJ pain.

Perspective: We report that complete Freund adjuvant induced temporomandibular joint (TMJ) inflammation upregulated hippocampal nerve growth factor (NGF) expression, and estradiol replacement potentiated this upregulation. These results propose that estradiol could modulate TMJ pain through the NGF signaling pathway in the hippocampus to exacerbate TMJ pain and offer a possible mechanism of sexual dimorphism of temporomandibular disorder pain. (C) 2012 by the American Pain Society

语种英语
所属项目编号30740046 ; 81070849
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000305366400006
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65760
Collection北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Ctr TMD & Orofacial Pain, Beijing 100081, Peoples R China
3.Peking Univ, Dept Neurobiol, Minist Educ & Hlth, Key Lab Neurosci, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Wu, Yu-Wei,Kou, Xiao-Xing,Bi, Rui-Yun,et al. Hippocampal Nerve Growth Factor Potentiated by 17 beta-Estradiol and Involved in Allodynia of Inflamed TMJ in Rat[J]. JOURNAL OF PAIN,2012,13(6):555-563.
APA Wu, Yu-Wei.,Kou, Xiao-Xing.,Bi, Rui-Yun.,Xu, Wen.,Wang, Ke-Wei.,...&Ma, Xu-Chen.(2012).Hippocampal Nerve Growth Factor Potentiated by 17 beta-Estradiol and Involved in Allodynia of Inflamed TMJ in Rat.JOURNAL OF PAIN,13(6),555-563.
MLA Wu, Yu-Wei,et al."Hippocampal Nerve Growth Factor Potentiated by 17 beta-Estradiol and Involved in Allodynia of Inflamed TMJ in Rat".JOURNAL OF PAIN 13.6(2012):555-563.
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