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The hematopoietic cell transplantation-specific comorbidity index (HCT-CI) is an outcome predictor for partially matched related donor transplantation
Mo, Xiao-Dong; Xu, Lan-Ping; Liu, Dai-Hong; Zhang, Xiao-Hui; Chen, Huan; Chen, Yu-Hong; Han, Wei; Wang, Yu; Wang, Feng-Rong; Wang, Jing-Zhi; Liu, Kai-Yan; Huang, Xiao-Jun1,2
刊名AMERICAN JOURNAL OF HEMATOLOGY
2013-06-01
DOI10.1002/ajh.23443
88期:6页:497-502
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; ACUTE MYELOID-LEUKEMIA ; INSULIN-RESISTANCE ; DISEASE STATUS ; CANCER ; TUMOR ; INFLAMMATION ; MULTICENTER ; MANAGEMENT
英文摘要

To validate the predictive ability of the Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) on the outcome of hematopoietic stem cell transplantation (HSCT) patients who received transplants from partially matched related donors (PMRD), a total of 526 patients who received PMRD HSCT between January 2006 and December 2009 at the Institute of Hematology, Peking University were enrolled. Patients were grouped according to their HCT-CI score; 31.0%, 31.4%, and 37.6% of patients had HCT-CI scores of 0, 12, and 3, respectively. Patients with HCT-CI scores of 3 had a significantly poorer 2-year overall survival (OS) than patients with HCT-CI scores of 02 (54.55% vs. 78.05%, P<0.001). In addition, patients with HCT-CI scores of 3 had a significantly higher 2-year cumulative incidence of relapse and nonrelapse mortality (NRM) than patients with scores of 02 (relapse: 23.23% vs. 11.59%, P<0.001; NRM: 34.30% vs. 15.93%, P<0.001). HCT-CI scores of <3 were associated with better OS, less relapse, and lower NRM in multivariate analysis. Patients who had high comorbidity scores as well as high-risk disease had the poorest outcomes. Therefore, we found that HCT-CI is associated with the outcomes of PMRD HSCT and we should closely monitor patients with a high comorbidity burden. Am. J. Hematol. 88:497502, 2013. (c) 2013 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000319293000009
项目编号2011AA020105 ; 81230013
资助机构National High Technology Research and Development Program of China (Program 863) ; Key Program of National Natural Science Foundation of China
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65761
专题北京大学第二临床医学院
北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Beijing Key Lab Hematopoiet Stem Cell Transplanta, Inst Hematol, Beijing 100044, Peoples R China
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Mo, Xiao-Dong,Xu, Lan-Ping,Liu, Dai-Hong,et al. The hematopoietic cell transplantation-specific comorbidity index (HCT-CI) is an outcome predictor for partially matched related donor transplantation[J]. AMERICAN JOURNAL OF HEMATOLOGY,2013,88(6):497-502.
APA Mo, Xiao-Dong.,Xu, Lan-Ping.,Liu, Dai-Hong.,Zhang, Xiao-Hui.,Chen, Huan.,...&Huang, Xiao-Jun.(2013).The hematopoietic cell transplantation-specific comorbidity index (HCT-CI) is an outcome predictor for partially matched related donor transplantation.AMERICAN JOURNAL OF HEMATOLOGY,88(6),497-502.
MLA Mo, Xiao-Dong,et al."The hematopoietic cell transplantation-specific comorbidity index (HCT-CI) is an outcome predictor for partially matched related donor transplantation".AMERICAN JOURNAL OF HEMATOLOGY 88.6(2013):497-502.
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