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学科主题: 临床医学
题名:
The hematopoietic cell transplantation-specific comorbidity index (HCT-CI) is an outcome predictor for partially matched related donor transplantation
作者: Mo, Xiao-Dong; Xu, Lan-Ping; Liu, Dai-Hong; Zhang, Xiao-Hui; Chen, Huan; Chen, Yu-Hong; Han, Wei; Wang, Yu; Wang, Feng-Rong; Wang, Jing-Zhi; Liu, Kai-Yan; Huang, Xiao-Jun1,2
刊名: AMERICAN JOURNAL OF HEMATOLOGY
发表日期: 2013-06-01
DOI: 10.1002/ajh.23443
卷: 88, 期:6, 页:497-502
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; ACUTE MYELOID-LEUKEMIA ; INSULIN-RESISTANCE ; DISEASE STATUS ; CANCER ; TUMOR ; INFLAMMATION ; MULTICENTER ; MANAGEMENT
英文摘要:

To validate the predictive ability of the Hematopoietic Cell Transplantation-Specific Comorbidity Index (HCT-CI) on the outcome of hematopoietic stem cell transplantation (HSCT) patients who received transplants from partially matched related donors (PMRD), a total of 526 patients who received PMRD HSCT between January 2006 and December 2009 at the Institute of Hematology, Peking University were enrolled. Patients were grouped according to their HCT-CI score; 31.0%, 31.4%, and 37.6% of patients had HCT-CI scores of 0, 12, and 3, respectively. Patients with HCT-CI scores of 3 had a significantly poorer 2-year overall survival (OS) than patients with HCT-CI scores of 02 (54.55% vs. 78.05%, P<0.001). In addition, patients with HCT-CI scores of 3 had a significantly higher 2-year cumulative incidence of relapse and nonrelapse mortality (NRM) than patients with scores of 02 (relapse: 23.23% vs. 11.59%, P<0.001; NRM: 34.30% vs. 15.93%, P<0.001). HCT-CI scores of <3 were associated with better OS, less relapse, and lower NRM in multivariate analysis. Patients who had high comorbidity scores as well as high-risk disease had the poorest outcomes. Therefore, we found that HCT-CI is associated with the outcomes of PMRD HSCT and we should closely monitor patients with a high comorbidity burden. Am. J. Hematol. 88:497502, 2013. (c) 2013 Wiley Periodicals, Inc.

语种: 英语
所属项目编号: 2011AA020105 ; 81230013
项目资助者: National High Technology Research and Development Program of China (Program 863) ; Key Program of National Natural Science Foundation of China
WOS记录号: WOS:000319293000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65761
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Beijing Key Lab Hematopoiet Stem Cell Transplanta, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Mo, Xiao-Dong,Xu, Lan-Ping,Liu, Dai-Hong,et al. The hematopoietic cell transplantation-specific comorbidity index (HCT-CI) is an outcome predictor for partially matched related donor transplantation[J]. AMERICAN JOURNAL OF HEMATOLOGY,2013,88(6):497-502.
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