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学科主题: 临床医学
题名:
The role of MCP-1-CCR2 ligand-receptor axis in chondrocyte degradation and disease progress in knee osteoarthritis
作者: Xu, Yuan-kun; Ke, Yan; Wang, Bin; Lin, Jian-hao1
关键词: MCP-1 ; CCR2 ; Osteoarthritis ; Chondrocyte ; Rat ; Mouse
刊名: BIOLOGICAL RESEARCH
发表日期: 2015-11-17
DOI: 10.1186/s40659-015-0057-0
卷: 48
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
关键词[WOS]: RHEUMATOID-ARTHRITIS ; HISTOLOGICAL ASSESSMENTS ; CHEMOKINE RECEPTORS ; ARTICULAR-CARTILAGE ; MODEL ; RAT ; RECOMMENDATIONS ; EXPRESSION ; BIOMARKERS ; JOINTS
英文摘要:

Background: Osteoarthritis (OA) is a common arthritic disease and multifactorial whole-joint disease. Interactions of chemokines and OA is inadequately documented.

Results: In vivo and in vitro studies were conducted to investigate monocyte chemoattractant protein 1 (MCP-1) and receptor chemokine (C-C motif) receptor 2 (CCR2) in chondrocyte degradation and cartilage degeneration. Chondrocytes from 16 OA patients and 6 normal controls were involved in this study. After stimulation of MCP-1, the expression of MCP-1 and CCR2 increased significantly (P < 0.001) and the expression of MMP-13 also increased (P < 0.05). MCP-1 stimulation also induced (or enhanced) the apoptosis of OA chondrocytes (P < 0.05). Additionally, the degradation of cartilage matrix markers (metalloproteinase 3 and 13, MMP3 and MMP13) in the culture medium of normal chondrocytes was also assessed. Furthermore, intra-articular injection of MCP-1 in mouse knees induced cartilage degradation and the CCR2 antagonist did not impede cartilage destroy in rats knees of monosodium iodoacetate (MIA) model.

Conclusions: The results of this study demonstrate that the MCP-1-CCR2 ligand-receptor axis plays a special role in the initiation and progression of OA pathology. Patients with ambiguous etiology can gain some insight from the MCP-1-CCR2 ligand-receptor axis.

语种: 英语
所属项目编号: 2107000065 ; 81441056
项目资助者: Beijing Municipal Science and Technology Commission ; National Natural Science Fund
WOS记录号: WOS:000365262000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65762
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Arthrit Clin, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Res Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Xu, Yuan-kun,Ke, Yan,Wang, Bin,et al. The role of MCP-1-CCR2 ligand-receptor axis in chondrocyte degradation and disease progress in knee osteoarthritis[J]. BIOLOGICAL RESEARCH,2015,48.
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