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The role of MCP-1-CCR2 ligand-receptor axis in chondrocyte degradation and disease progress in knee osteoarthritis
Xu, Yuan-kun; Ke, Yan; Wang, Bin; Lin, Jian-hao1
关键词MCP-1 CCR2 Osteoarthritis Chondrocyte Rat Mouse
刊名BIOLOGICAL RESEARCH
2015-11-17
DOI10.1186/s40659-015-0057-0
48
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biology
研究领域[WOS]Life Sciences & Biomedicine - Other Topics
关键词[WOS]RHEUMATOID-ARTHRITIS ; HISTOLOGICAL ASSESSMENTS ; CHEMOKINE RECEPTORS ; ARTICULAR-CARTILAGE ; MODEL ; RAT ; RECOMMENDATIONS ; EXPRESSION ; BIOMARKERS ; JOINTS
英文摘要

Background: Osteoarthritis (OA) is a common arthritic disease and multifactorial whole-joint disease. Interactions of chemokines and OA is inadequately documented.

Results: In vivo and in vitro studies were conducted to investigate monocyte chemoattractant protein 1 (MCP-1) and receptor chemokine (C-C motif) receptor 2 (CCR2) in chondrocyte degradation and cartilage degeneration. Chondrocytes from 16 OA patients and 6 normal controls were involved in this study. After stimulation of MCP-1, the expression of MCP-1 and CCR2 increased significantly (P < 0.001) and the expression of MMP-13 also increased (P < 0.05). MCP-1 stimulation also induced (or enhanced) the apoptosis of OA chondrocytes (P < 0.05). Additionally, the degradation of cartilage matrix markers (metalloproteinase 3 and 13, MMP3 and MMP13) in the culture medium of normal chondrocytes was also assessed. Furthermore, intra-articular injection of MCP-1 in mouse knees induced cartilage degradation and the CCR2 antagonist did not impede cartilage destroy in rats knees of monosodium iodoacetate (MIA) model.

Conclusions: The results of this study demonstrate that the MCP-1-CCR2 ligand-receptor axis plays a special role in the initiation and progression of OA pathology. Patients with ambiguous etiology can gain some insight from the MCP-1-CCR2 ligand-receptor axis.

语种英语
WOS记录号WOS:000365262000001
项目编号2107000065 ; 81441056
资助机构Beijing Municipal Science and Technology Commission ; National Natural Science Fund
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65762
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Arthrit Clin, Beijing 100871, Peoples R China
2.Peking Univ, Peoples Hosp, Res Ctr, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xu, Yuan-kun,Ke, Yan,Wang, Bin,et al. The role of MCP-1-CCR2 ligand-receptor axis in chondrocyte degradation and disease progress in knee osteoarthritis[J]. BIOLOGICAL RESEARCH,2015,48.
APA Xu, Yuan-kun,Ke, Yan,Wang, Bin,&Lin, Jian-hao.(2015).The role of MCP-1-CCR2 ligand-receptor axis in chondrocyte degradation and disease progress in knee osteoarthritis.BIOLOGICAL RESEARCH,48.
MLA Xu, Yuan-kun,et al."The role of MCP-1-CCR2 ligand-receptor axis in chondrocyte degradation and disease progress in knee osteoarthritis".BIOLOGICAL RESEARCH 48(2015).
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