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学科主题: 基础医学
题名:
Mammalian cell cycles without cyclin E-CDK2
作者: Yu, QY; Sicinski, P
关键词: cyclin E ; CDK2 ; cell cycle ; mouse knockout
刊名: CELL CYCLE
发表日期: 2004-03-01
卷: 3, 期:3, 页:292-295
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: HISTONE GENE-TRANSCRIPTION ; S-PHASE ; DEPENDENT KINASES ; DNA-REPLICATION ; RETINOBLASTOMA PROTEIN ; CENTROSOME DUPLICATION ; P300 COACTIVATOR ; FREE SYSTEM ; G1 CYCLIN ; CDK2
英文摘要:

The family of mammalian E-type cyclins is composed of two proteins, termed cyclin E1 and E2. These two cyclins are widely expressed in proliferating cells. E-cyclins bind and activate cyclin dependent kinase CDK2. Cyclin E-CDK2 complexes were believed to play critical function in driving cell cycle progression of normal, nontransformed cells and of cancer cells. Several recent reports challenge this notion.

语种: 英语
WOS记录号: WOS:000222361400019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65763
Appears in Collections:基础医学院_细胞生物学系_期刊论文

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作者单位: 1.Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
2.Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
3.Beijing Univ, Beijing Tumor Hosp, Dept Cell Biol, Beijing 100871, Peoples R China
4.Beijing Univ, Beijing Canc Inst, Beijing 100871, Peoples R China

Recommended Citation:
Yu, QY,Sicinski, P. Mammalian cell cycles without cyclin E-CDK2[J]. CELL CYCLE,2004,3(3):292-295.
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