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学科主题: 临床医学
题名:
Estimated Dietary Acid Load Is Not Associated with Blood Pressure or Hypertension Incidence in Men Who Are Approximately 70 Years Old
作者: Luis, Desiree1,2; Huang, Xiaoyan1,2,4; Riserus, Ulf5; Sjogren, Per5; Lindholm, Bengt1,2; Arnlov, Johan6,7; Cederholm, Tommy5; Carrero, Juan Jesos1,2,3
关键词: chronic kidney disease ; metabolic acidosis ; nutritional epidemiology ; renal nutrition ; dip
刊名: JOURNAL OF NUTRITION
发表日期: 2015-02-01
DOI: 10.3945/jn.114.197020
卷: 145, 期:2, 页:315-321
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: SERUM ANION GAP ; INTRACELLULAR PH ; EXCRETION ; HUMANS ; CALCIUM ; DISEASE ; RISK ; SENSITIVITY ; MANAGEMENT ; POTASSIUM
英文摘要:

Background: Dietary acid load affects acid-base homeostasis, which may be associated with blood pressure (BP). Previous research on dietary acid load and BP in the community has provided conflicting results, which may be confounded by underlying kidney function with inability to eliminate acid excess.

Objective: The objective of this study was to determine whether dietary acid load is associated with blood pressure or the incidence of hypertension in older men taking into account each individual′s kidney function.

Methods: We included 673 men aged 70-71 y and not receiving antihypertensive medication from the Uppsala Longitudinal Study of Adult Men. Of those, 378 men were re-examined after 7 y. Dietary acid load was estimated at baseline by potential renal acid load (PRAL) and net endogenous acid production (NEAP), based on nutrient intake assessed by 7-d food records at baseline. Ambulatory blood pressure monitoring (ABPM) was performed at both visits. Cystatin C-estimated kidney function allowed identification of underlying chronic kidney disease.

Results: Median estimated PRAL and NEAP were 3.3 and 40.7 mEq/d, respectively. In cross-section, PRAL was in general not associated with ABPM measurements (all P > 0.05, except for the 24-h diastolic BP). During follow-up, PRAL did not predict ABPM changes (all P > 0.05). When individuals with baseline hypertension (ABPM >= 130/80 mm Hg) or nondippers (with nighttime-to-daytime systolic BP ratio > 0.9) were excluded, PRAL was not a predictor of incident cases (P > 0.30). Kidney function did not modify these null relations. Similar findings were obtained with the use of NEAP as the exposure.

Conclusion: Our analyses linking estimated dietary acid load with BP outcome measurements both cross-sectionally and after 7 y in community-based older Swedish men of similar age did not reveal an association between dietary acid load and BP.

语种: 英语
项目资助者: Swedish Research Council
WOS记录号: WOS:000349057200018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65768
Appears in Collections:北京大学深圳医院_肾内科_期刊论文

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作者单位: 1.Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Renal Med, Stockholm, Sweden
2.Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Baxter Novum, Stockholm, Sweden
3.Peking Univ, Shenzhen Hosp, Div Nephrol, Shenzhen, Peoples R China
4.Uppsala Univ, Dept Publ Hlth & Caring Sci, Geriatr Sect, Uppsala, Sweden
5.Karolinska Inst, Ctr Mol Med, Stockholm, Sweden
6.Uppsala Univ, Uppsala, Sweden
7.Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden

Recommended Citation:
Luis, Desiree,Huang, Xiaoyan,Riserus, Ulf,et al. Estimated Dietary Acid Load Is Not Associated with Blood Pressure or Hypertension Incidence in Men Who Are Approximately 70 Years Old[J]. JOURNAL OF NUTRITION,2015,145(2):315-321.
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