IR@PKUHSC  > 北京大学第三临床医学院  > 消化科
学科主题临床医学
Esophageal intraluminal baseline impedance is associated with severity of acid reflux and epithelial structural abnormalities in patients with gastroesophageal reflux disease
Zhong, Chanjuan; Duan, Liping; Wang, Kun; Xu, Zhijie; Ge, Ying; Yang, Changqing; Han, Yajing
关键词Baseline impedance Acid reflux Intercellular spaces Tight junction
刊名JOURNAL OF GASTROENTEROLOGY
2013-05-01
DOI10.1007/s00535-012-0689-6
48期:5页:601-610
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]DILATED INTERCELLULAR SPACES ; IMPAIR MUCOSAL INTEGRITY ; TIGHT-JUNCTION PROTEINS ; OMEPRAZOLE TREATMENT ; BILE ; PERMEABILITY ; EXPRESSION ; SYMPTOMS ; EXPOSURE ; LIGHT
英文摘要

The esophageal intraluminal baseline impedance may be used to evaluate the status of mucosa integrity. Esophageal acid exposure decreases the baseline impedance. We aimed to compare baseline impedance in patients with various reflux events and with different acid-related parameters, and investigate the relationships between epithelial histopathologic abnormalities and baseline impedance.

A total of 229 GERD patients and 34 controls underwent 24-h multichannel intraluminal impedance and pH monitoring (MII-pH monitoring), gastroendoscopy, and completed a GERD questionnaire (GerdQ). We quantified epithelial intercellular spaces (ICSs) and expression of tight junction (TJ) proteins by histologic techniques.

Mean baseline values in reflux esophagitis (RE) (1752 +/- A 1018 Omega) and non-erosive reflux disease (NERD) (2640 +/- A 1143 Omega) were significantly lower than in controls (3360 +/- A 1258 Omega; p < 0.001 and p = 0.001, respectively). Among NERD subgroups, mean baselines in the acid reflux group (2510 +/- A 1239 Omega) and mixed acid/weakly acidic reflux group (2393 +/- A 1009 Omega) were much lower than in controls (3360 +/- A 1258 Omega; p = 0.020 and p < 0.001, respectively). The mean baseline in severe RE patients was significantly lower than in mild RE patients (LA-C/D vs. LA-A/B: 970 +/- A 505 Omega vs. 1921 +/- A 1024 Omega, p < 0.001). There was a significant negative correlation between baseline value and acid exposure time (AET) (r = -0.41, p < 0.001), and a weak but significant correlation (r = -0.20, p = 0.007) between baseline value and weakly AET. Negative correlations were observed between ICS and the baseline impedance (r = -0.637, p < 0.001) and claudin-1 and the baseline impedance (r = -0.648, p < 0.001).

Patients with dominant acid reflux events and with longer AET have low baseline impedance. Baseline values are correlated with esophageal mucosal histopathologic changes such as dilated ICS and TJ alteration.

语种英语
WOS记录号WOS:000319068700004
项目编号SZR08-3-03
资助机构Natural Science Funding of Beijing
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65772
专题北京大学第三临床医学院_消化科
北京大学医学部管理机构_科学研究处
作者单位Peking Univ, Dept Gastroenterol, Hosp 3, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhong, Chanjuan,Duan, Liping,Wang, Kun,et al. Esophageal intraluminal baseline impedance is associated with severity of acid reflux and epithelial structural abnormalities in patients with gastroesophageal reflux disease[J]. JOURNAL OF GASTROENTEROLOGY,2013,48(5):601-610.
APA Zhong, Chanjuan.,Duan, Liping.,Wang, Kun.,Xu, Zhijie.,Ge, Ying.,...&Han, Yajing.(2013).Esophageal intraluminal baseline impedance is associated with severity of acid reflux and epithelial structural abnormalities in patients with gastroesophageal reflux disease.JOURNAL OF GASTROENTEROLOGY,48(5),601-610.
MLA Zhong, Chanjuan,et al."Esophageal intraluminal baseline impedance is associated with severity of acid reflux and epithelial structural abnormalities in patients with gastroesophageal reflux disease".JOURNAL OF GASTROENTEROLOGY 48.5(2013):601-610.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhong, Chanjuan]的文章
[Duan, Liping]的文章
[Wang, Kun]的文章
百度学术
百度学术中相似的文章
[Zhong, Chanjuan]的文章
[Duan, Liping]的文章
[Wang, Kun]的文章
必应学术
必应学术中相似的文章
[Zhong, Chanjuan]的文章
[Duan, Liping]的文章
[Wang, Kun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。