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学科主题: 临床医学
题名:
Esophageal intraluminal baseline impedance is associated with severity of acid reflux and epithelial structural abnormalities in patients with gastroesophageal reflux disease
作者: Zhong, Chanjuan; Duan, Liping; Wang, Kun; Xu, Zhijie; Ge, Ying; Yang, Changqing; Han, Yajing
关键词: Baseline impedance ; Acid reflux ; Intercellular spaces ; Tight junction
刊名: JOURNAL OF GASTROENTEROLOGY
发表日期: 2013-05-01
DOI: 10.1007/s00535-012-0689-6
卷: 48, 期:5, 页:601-610
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: DILATED INTERCELLULAR SPACES ; IMPAIR MUCOSAL INTEGRITY ; TIGHT-JUNCTION PROTEINS ; OMEPRAZOLE TREATMENT ; BILE ; PERMEABILITY ; EXPRESSION ; SYMPTOMS ; EXPOSURE ; LIGHT
英文摘要:

The esophageal intraluminal baseline impedance may be used to evaluate the status of mucosa integrity. Esophageal acid exposure decreases the baseline impedance. We aimed to compare baseline impedance in patients with various reflux events and with different acid-related parameters, and investigate the relationships between epithelial histopathologic abnormalities and baseline impedance.

A total of 229 GERD patients and 34 controls underwent 24-h multichannel intraluminal impedance and pH monitoring (MII-pH monitoring), gastroendoscopy, and completed a GERD questionnaire (GerdQ). We quantified epithelial intercellular spaces (ICSs) and expression of tight junction (TJ) proteins by histologic techniques.

Mean baseline values in reflux esophagitis (RE) (1752 +/- A 1018 Omega) and non-erosive reflux disease (NERD) (2640 +/- A 1143 Omega) were significantly lower than in controls (3360 +/- A 1258 Omega; p < 0.001 and p = 0.001, respectively). Among NERD subgroups, mean baselines in the acid reflux group (2510 +/- A 1239 Omega) and mixed acid/weakly acidic reflux group (2393 +/- A 1009 Omega) were much lower than in controls (3360 +/- A 1258 Omega; p = 0.020 and p < 0.001, respectively). The mean baseline in severe RE patients was significantly lower than in mild RE patients (LA-C/D vs. LA-A/B: 970 +/- A 505 Omega vs. 1921 +/- A 1024 Omega, p < 0.001). There was a significant negative correlation between baseline value and acid exposure time (AET) (r = -0.41, p < 0.001), and a weak but significant correlation (r = -0.20, p = 0.007) between baseline value and weakly AET. Negative correlations were observed between ICS and the baseline impedance (r = -0.637, p < 0.001) and claudin-1 and the baseline impedance (r = -0.648, p < 0.001).

Patients with dominant acid reflux events and with longer AET have low baseline impedance. Baseline values are correlated with esophageal mucosal histopathologic changes such as dilated ICS and TJ alteration.

语种: 英语
所属项目编号: SZR08-3-03
项目资助者: Natural Science Funding of Beijing
WOS记录号: WOS:000319068700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65772
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: Peking Univ, Dept Gastroenterol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Zhong, Chanjuan,Duan, Liping,Wang, Kun,et al. Esophageal intraluminal baseline impedance is associated with severity of acid reflux and epithelial structural abnormalities in patients with gastroesophageal reflux disease[J]. JOURNAL OF GASTROENTEROLOGY,2013,48(5):601-610.
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