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学科主题: 口腔医学
题名:
Association analysis between the -2518MCP-1(A/G) polymorphism and generalized aggressive periodontitis in a Chinese population
作者: Zhu, X. L.1,2; Meng, H. X.1; Zhang, L.1; Xu, L.1; Chen, Z. B.1; Shi, D.1; Feng, X. H.1; Zhang, X.1
关键词: aggressive periodontitis ; genetics ; monocyte chemoattractant protein 1 (MCP-1) ; monocytes
刊名: JOURNAL OF PERIODONTAL RESEARCH
发表日期: 2012-06-01
DOI: 10.1111/j.1600-0765.2011.01426.x
卷: 47, 期:3, 页:286-292
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: MONOCYTE CHEMOATTRACTANT PROTEIN-1 ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; MCP-1 PROMOTER POLYMORPHISM ; GENE REGULATORY REGION ; RHEUMATOID-ARTHRITIS ; SPANISH PATIENTS ; EXPRESSION ; SUSCEPTIBILITY ; DISEASE ; TISSUES
英文摘要:

Background and Objective: It has been suggested that aggressive periodontitis has a genetic basis. Monocyte chemoattractant protein 1 (MCP-1) plays a critical role in the recruitment of monocytes and the development of periodontitis. The) 2518MCP-1(A/ G) polymorphism has been implicated as a risk or susceptibility factor for a variety of autoimmune conditions and inflammatory diseases. The intent of this investigation was to study whether the) 2518MCP-1(A/ G) polymorphism is associated with generalized aggressive periodontitis in the Chinese population. Material and Methods: One hundred and twenty-four patients with generalized aggressive periodontitis and 94 healthy subjects were included in this case-control study. Genomic DNA was isolated from a peripheral blood sample obtained from each subject. Gene polymorphisms of) 2518MCP-1(A/ G) were analyzed by a standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. A logistic regression analysis was performed to test the association between the) 2518MCP-1(A/ G) genotype (alleles) and generalized aggressive periodontitis with adjustment of the major covariates (gender, age and smoking status). Results: There was no significant association of the) 2518MCP-1(A/ G) polymorphism with generalized aggressive periodontitis in the unstratified subjects. However, when patients were stratified by gender, the frequency of the G + genotype was significantly lower in female patients with generalized aggressive periodontitis compared with female controls (p = 0.036, adjusted odds ratio = 0.3, 95% CI: 0.1-0.9). In female patients with generalized aggressive periodontitis, the probing pocket depth was larger in subjects with the AA genotype than in subjects with the G + genotype (5.07 mm vs. 4.30 mm; Z =) 2.470, p = 0.014). Conclusion: The polymorphisms of) 2518MCP-1 may play an important role in determining generalized aggressive periodontitis susceptibility in this cohort of Chinese women.

语种: 英语
所属项目编号: 30271411 ; 30471882 ; 2007BAZ18B02 ; 2002AA217091
项目资助者: National Natural Science Foundation of China ; National Key Project of Scientific and Technical Supporting Programs of China ; National High Tech Program (&prime ; 863&prime ; Program)
WOS记录号: WOS:000302999400002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65774
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Peking Univ, Dept Periodontol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Dept Stomatol, Peoples Hosp, Beijing 100081, Peoples R China

Recommended Citation:
Zhu, X. L.,Meng, H. X.,Zhang, L.,et al. Association analysis between the -2518MCP-1(A/G) polymorphism and generalized aggressive periodontitis in a Chinese population[J]. JOURNAL OF PERIODONTAL RESEARCH,2012,47(3):286-292.
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