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学科主题口腔医学
Association analysis between the -2518MCP-1(A/G) polymorphism and generalized aggressive periodontitis in a Chinese population
Zhu, X. L.1,2; Meng, H. X.1; Zhang, L.1; Xu, L.1; Chen, Z. B.1; Shi, D.1; Feng, X. H.1; Zhang, X.1
关键词aggressive periodontitis genetics monocyte chemoattractant protein 1 (MCP-1) monocytes
刊名JOURNAL OF PERIODONTAL RESEARCH
2012-06-01
DOI10.1111/j.1600-0765.2011.01426.x
47期:3页:286-292
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]MONOCYTE CHEMOATTRACTANT PROTEIN-1 ; SYSTEMIC-LUPUS-ERYTHEMATOSUS ; MCP-1 PROMOTER POLYMORPHISM ; GENE REGULATORY REGION ; RHEUMATOID-ARTHRITIS ; SPANISH PATIENTS ; EXPRESSION ; SUSCEPTIBILITY ; DISEASE ; TISSUES
英文摘要

Background and Objective: It has been suggested that aggressive periodontitis has a genetic basis. Monocyte chemoattractant protein 1 (MCP-1) plays a critical role in the recruitment of monocytes and the development of periodontitis. The) 2518MCP-1(A/ G) polymorphism has been implicated as a risk or susceptibility factor for a variety of autoimmune conditions and inflammatory diseases. The intent of this investigation was to study whether the) 2518MCP-1(A/ G) polymorphism is associated with generalized aggressive periodontitis in the Chinese population. Material and Methods: One hundred and twenty-four patients with generalized aggressive periodontitis and 94 healthy subjects were included in this case-control study. Genomic DNA was isolated from a peripheral blood sample obtained from each subject. Gene polymorphisms of) 2518MCP-1(A/ G) were analyzed by a standard polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. A logistic regression analysis was performed to test the association between the) 2518MCP-1(A/ G) genotype (alleles) and generalized aggressive periodontitis with adjustment of the major covariates (gender, age and smoking status). Results: There was no significant association of the) 2518MCP-1(A/ G) polymorphism with generalized aggressive periodontitis in the unstratified subjects. However, when patients were stratified by gender, the frequency of the G + genotype was significantly lower in female patients with generalized aggressive periodontitis compared with female controls (p = 0.036, adjusted odds ratio = 0.3, 95% CI: 0.1-0.9). In female patients with generalized aggressive periodontitis, the probing pocket depth was larger in subjects with the AA genotype than in subjects with the G + genotype (5.07 mm vs. 4.30 mm; Z =) 2.470, p = 0.014). Conclusion: The polymorphisms of) 2518MCP-1 may play an important role in determining generalized aggressive periodontitis susceptibility in this cohort of Chinese women.

语种英语
WOS记录号WOS:000302999400002
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65774
Collection北京大学口腔医学院_牙周科
作者单位1.Peking Univ, Dept Periodontol, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Dept Stomatol, Peoples Hosp, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Zhu, X. L.,Meng, H. X.,Zhang, L.,et al. Association analysis between the -2518MCP-1(A/G) polymorphism and generalized aggressive periodontitis in a Chinese population[J]. JOURNAL OF PERIODONTAL RESEARCH,2012,47(3):286-292.
APA Zhu, X. L..,Meng, H. X..,Zhang, L..,Xu, L..,Chen, Z. B..,...&Zhang, X..(2012).Association analysis between the -2518MCP-1(A/G) polymorphism and generalized aggressive periodontitis in a Chinese population.JOURNAL OF PERIODONTAL RESEARCH,47(3),286-292.
MLA Zhu, X. L.,et al."Association analysis between the -2518MCP-1(A/G) polymorphism and generalized aggressive periodontitis in a Chinese population".JOURNAL OF PERIODONTAL RESEARCH 47.3(2012):286-292.
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