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学科主题: 临床医学
题名:
Human RIF1 encodes an anti-apoptotic factor required for DNA repair
作者: Wang, Haibo1; Zhao, Ailian2; Chen, Lin1; Zhong, Xueyan3; Liao, Ji1; Gao, Min4; Cai, Minghua1; Lee, Dong-Hyun5; Li, Jing1; Chowdhury, Dipanjan5; Yang, Yun-gui4; Pfeifer, Gerd P.3; Yen, Yun6; Xu, Xingzhi1
刊名: CARCINOGENESIS
发表日期: 2009-08-01
DOI: 10.1093/carcin/bgp136
卷: 30, 期:8, 页:1314-1319
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: MAMMALIAN-CELLS ; PATHWAYS ; DAMAGE ; PHOSPHORYLATION ; METASTASIS ; NETWORKS ; MELANOMA ; REVEALS ; COMPLEX
英文摘要:

Human Rap1-interacting protein 1 (RIF1) contributes to the ataxia telangiectasia, mutated-mediated DNA damage response against the dexterous effect of DNA lesions and plays a critical role in the S-phase checkpoint. However, the molecular mechanisms by which human RIF1 conquers DNA aberrations remain largely unknown. We here showed that inhibition of RIF1 expression by small interfering RNA led to defective homologous recombination-mediated DNA double-strand break repair and sensitized cancer cells to camptothecin or staurosporine treatment. RIF1 underwent caspase-dependent cleavage upon apoptosis. We further found that RIF1 was highly expressed in human breast tumors, and its expression status was positively correlated with differentiation degrees of invasive ductal carcinoma of the breast. Our results suggest that RIF1 encodes an anti-apoptotic factor required for DNA repair and is a potential target for cancer treatment.

语种: 英语
WOS记录号: WOS:000268586400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65775
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Capital Normal Univ, Coll Life Sci, Canc Biol Lab, Beijing 100048, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Ins,Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
3.City Hope Natl Med Ctr, Div Biol, Duarte, CA 91010 USA
4.Chinese Acad Sci, Beijing Inst Genom, Genome Stabil Grp, Beijing 100029, Peoples R China
5.Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA
6.City Hope Natl Med Ctr, Div Mol & Clin Pharmacol, Duarte, CA 91010 USA

Recommended Citation:
Wang, Haibo,Zhao, Ailian,Chen, Lin,et al. Human RIF1 encodes an anti-apoptotic factor required for DNA repair[J]. CARCINOGENESIS,2009,30(8):1314-1319.
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