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学科主题临床医学
Human RIF1 encodes an anti-apoptotic factor required for DNA repair
Wang, Haibo1; Zhao, Ailian2; Chen, Lin1; Zhong, Xueyan3; Liao, Ji1; Gao, Min4; Cai, Minghua1; Lee, Dong-Hyun5; Li, Jing1; Chowdhury, Dipanjan5; Yang, Yun-gui4; Pfeifer, Gerd P.3; Yen, Yun6; Xu, Xingzhi1
刊名CARCINOGENESIS
2009-08-01
DOI10.1093/carcin/bgp136
30期:8页:1314-1319
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]MAMMALIAN-CELLS ; PATHWAYS ; DAMAGE ; PHOSPHORYLATION ; METASTASIS ; NETWORKS ; MELANOMA ; REVEALS ; COMPLEX
英文摘要

Human Rap1-interacting protein 1 (RIF1) contributes to the ataxia telangiectasia, mutated-mediated DNA damage response against the dexterous effect of DNA lesions and plays a critical role in the S-phase checkpoint. However, the molecular mechanisms by which human RIF1 conquers DNA aberrations remain largely unknown. We here showed that inhibition of RIF1 expression by small interfering RNA led to defective homologous recombination-mediated DNA double-strand break repair and sensitized cancer cells to camptothecin or staurosporine treatment. RIF1 underwent caspase-dependent cleavage upon apoptosis. We further found that RIF1 was highly expressed in human breast tumors, and its expression status was positively correlated with differentiation degrees of invasive ductal carcinoma of the breast. Our results suggest that RIF1 encodes an anti-apoptotic factor required for DNA repair and is a potential target for cancer treatment.

语种英语
WOS记录号WOS:000268586400006
引用统计
被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65775
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_病理科
作者单位1.Capital Normal Univ, Coll Life Sci, Canc Biol Lab, Beijing 100048, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Ins,Dept Pathol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
3.City Hope Natl Med Ctr, Div Biol, Duarte, CA 91010 USA
4.Chinese Acad Sci, Beijing Inst Genom, Genome Stabil Grp, Beijing 100029, Peoples R China
5.Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA
6.City Hope Natl Med Ctr, Div Mol & Clin Pharmacol, Duarte, CA 91010 USA
推荐引用方式
GB/T 7714
Wang, Haibo,Zhao, Ailian,Chen, Lin,et al. Human RIF1 encodes an anti-apoptotic factor required for DNA repair[J]. CARCINOGENESIS,2009,30(8):1314-1319.
APA Wang, Haibo.,Zhao, Ailian.,Chen, Lin.,Zhong, Xueyan.,Liao, Ji.,...&Xu, Xingzhi.(2009).Human RIF1 encodes an anti-apoptotic factor required for DNA repair.CARCINOGENESIS,30(8),1314-1319.
MLA Wang, Haibo,et al."Human RIF1 encodes an anti-apoptotic factor required for DNA repair".CARCINOGENESIS 30.8(2009):1314-1319.
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