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Comprehensive Chemical Analysis of the Rhizomes of Drynaria fortunei by Orthogonal Pre-Separation and Liquid Chromatography Mass Spectrometry
Qiao, Xue1; Lin, Xiong-hao1; Liang, Yong-hong1; Dong, Jing2; Guo, De-an1; Ye, Min1
关键词Drynaria fortune Polypodiaceae pre-separation proanthocyanidins orthogonal chromatography HPLC-DAD-ESI-MSn
刊名PLANTA MEDICA
2014-03-01
DOI10.1055/s-0033-1360362
80期:4页:330-336
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]PROANTHOCYANIDINS
英文摘要

The chemical composition of Drynaria fortunei, a traditional Chinese herbal medicine, is very complicated. In order to separate these chemicals to obtain their structural information, an orthogonal sample enrichment procedure was established. The ethyl acetate extract of D. fortunei was pre-separated by Sephadex LH-20 x polyamide columns to yield 15 fractions. These fractions were analyzed successively using a reversed-phase Agilent Zorbax SB-C-18 column, coupled with diode array detection and electrospray ionization tandem mass spectrometry. The method reduced co-elution and enriched minor compounds on the basis of their chemical features. A total of 369 compounds were detected by LC/MSn, compared to less than 50 compounds without pre-separation. The pretreatment facilitated the analytical separation of flavonoids, proanthocyanidins, triterpenoids, phenolic acids, and lignans in D. fortunei, and allowed a comprehensive chemical profiling of these constituents. This method could be applied to other multicomponent herbal extracts.

语种英语
WOS记录号WOS:000332395000012
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65779
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Shimadzu Int Trading Shanghai Co Ltd, Beijing Off, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Qiao, Xue,Lin, Xiong-hao,Liang, Yong-hong,et al. Comprehensive Chemical Analysis of the Rhizomes of Drynaria fortunei by Orthogonal Pre-Separation and Liquid Chromatography Mass Spectrometry[J]. PLANTA MEDICA,2014,80(4):330-336.
APA Qiao, Xue,Lin, Xiong-hao,Liang, Yong-hong,Dong, Jing,Guo, De-an,&Ye, Min.(2014).Comprehensive Chemical Analysis of the Rhizomes of Drynaria fortunei by Orthogonal Pre-Separation and Liquid Chromatography Mass Spectrometry.PLANTA MEDICA,80(4),330-336.
MLA Qiao, Xue,et al."Comprehensive Chemical Analysis of the Rhizomes of Drynaria fortunei by Orthogonal Pre-Separation and Liquid Chromatography Mass Spectrometry".PLANTA MEDICA 80.4(2014):330-336.
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