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学科主题: 临床医学
题名:
Aberrant galactosylation of IgA1 is involved in the genetic susceptibility of Chinese patients with IgA nephropathy
作者: Lin, Xiaojie; Ding, Jiaxiang; Zhu, Li; Shi, Sufang; Jiang, Lei; Zhao, Minghui; Zhang, Hong1
关键词: Ga1-deficient ; genetic susceptibility ; glycosylation ; HAA ; IgA1
刊名: NEPHROLOGY DIALYSIS TRANSPLANTATION
发表日期: 2009-11-01
DOI: 10.1093/ndt/gfp294
卷: 24, 期:11, 页:3372-3375
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Transplantation ; Urology & Nephrology
研究领域[WOS]: Transplantation ; Urology & Nephrology
关键词[WOS]: SERUM IGA1 ; GLOMERULONEPHRITIS ; VARIANTS
英文摘要:

Background. Immunoglobulin A nephropathy (IgAN) is associated with genetic and environmental factors, and undergalactosylation of IgA1 in the serum is considered to be a contributor to pathogenesis of IgAN. The present study was conducted to detect the galactose- (Gal) deficient IgA1 level in Chinese IgAN patients and their family members.

Methods. Sixty-three IgAN patients were enrolled, where 32 first-degree relatives of 19 patients and 44 spouses of 44 patients were recruited. Healthy blood donors (n = 39) were used as normal controls. Biotinylated HAA (Helix aspersa) was utilized to detect the Gal-deficient IgA1 in enzyme-linked immunosorbent assay (ELISA). All the results were corrected by serum IgA1 concentration.

Results. Compared with normal controls, the sera IgA1 of patients and their first-degree relatives demonstrated increased Gal-deficient IgA1 level (0.17 +/- 0.09 versus 0.10 +/- 0.04, P = 0.001; 0.14 +/- 0.07 versus 0.10 +/- 0.04, P = 0.028); no significant difference between patients and their first-degree relatives was detected (0.17 0.09 versus 0.14 +/- 0.07, P = 0.127). In contrast, serum Gal-deficient IgA1 level of IgAN patients was higher than their counterpart spouses and normal controls (0.18 +/- 0.13 versus 0.14 +/- 0.09, P = 0.009; 0.18 +/- 0.13 versus 0.10 +/- 0.04, P = 0.001), while that of patients′ spouses was comparable with normal controls (0.14 +/- 0.09 versus 0.10 +/- 0.04, P = 0.075). There was no correlation between clinicopathological data and serum Gal-deficient IgA1 level.

Conclusion. The patients with IgAN and their first relatives showed significant higher Gal-deficient IgA1 level than healthy controls, whereas patients′ spouses were the same as healthy controls. It can be suggested that the Galdeficient IgA1 might be inherited in Chinese patients with IgAN.

语种: 英语
所属项目编号: 30670981 ; 30825021 ; 200802052
项目资助者: NSCF ; Foundation of Ministry of Health of China
WOS记录号: WOS:000271718900023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65782
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
2.Peking Univ, Div Renal, Dept Med, Inst Nephrol,Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Lin, Xiaojie,Ding, Jiaxiang,Zhu, Li,et al. Aberrant galactosylation of IgA1 is involved in the genetic susceptibility of Chinese patients with IgA nephropathy[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2009,24(11):3372-3375.
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