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学科主题: 药学
题名:
Effects of lanthanide ions (La3+, Gd3+, Yb3+) on production of reactive oxygen species in mitochondria
作者: Liu Hui-Xue; Yang Xiao-Da; Wang Kui
关键词: lanthanide ; mitochondria ; reactive oxygen species(ROS)
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2006-06-01
卷: 27, 期:6, 页:999-1002
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
英文摘要:

The effects of lanthanides (Ln) on the production of reactive oxygen species(ROS) in isolated mitochondria were investigated by fluorescence assays upon incubation with Ln(3+). The results show that Ln(3+) (La3+, Gd3+, Yb3+) could reduce the rates of overall ROS production. The results obtained from experiments on xanthine/xanthine oxidative enzyme system suggest that Ln(3+) ions can reduce the formation of O-center dot(2)-, but H2O2 did not react with Ln(3+). The influences of Ln(3+) on the activities of metabolize enzymes (GSH-Px and Mn-SOD) indicate that Ln(3+) could decrease the activity of Mn-SOD, but could not affect the activity of GSH-Px. The effects of Ln(3+) on cellular H2O2 level are discussed.

语种: 中文
WOS记录号: WOS:000238377500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65788
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China

Recommended Citation:
Liu Hui-Xue,Yang Xiao-Da,Wang Kui. Effects of lanthanide ions (La3+, Gd3+, Yb3+) on production of reactive oxygen species in mitochondria[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2006,27(6):999-1002.
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