IR@PKUHSC  > 北京大学药学院  > 化学生物学系
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Effects of lanthanide ions (La3+, Gd3+, Yb3+) on production of reactive oxygen species in mitochondria
Liu Hui-Xue; Yang Xiao-Da; Wang Kui
关键词lanthanide mitochondria reactive oxygen species(ROS)
刊名CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
2006-06-01
27期:6页:999-1002
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
英文摘要

The effects of lanthanides (Ln) on the production of reactive oxygen species(ROS) in isolated mitochondria were investigated by fluorescence assays upon incubation with Ln(3+). The results show that Ln(3+) (La3+, Gd3+, Yb3+) could reduce the rates of overall ROS production. The results obtained from experiments on xanthine/xanthine oxidative enzyme system suggest that Ln(3+) ions can reduce the formation of O-center dot(2)-, but H2O2 did not react with Ln(3+). The influences of Ln(3+) on the activities of metabolize enzymes (GSH-Px and Mn-SOD) indicate that Ln(3+) could decrease the activity of Mn-SOD, but could not affect the activity of GSH-Px. The effects of Ln(3+) on cellular H2O2 level are discussed.

语种中文
WOS记录号WOS:000238377500003
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65788
专题北京大学药学院_化学生物学系
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Liu Hui-Xue,Yang Xiao-Da,Wang Kui. Effects of lanthanide ions (La3+, Gd3+, Yb3+) on production of reactive oxygen species in mitochondria[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2006,27(6):999-1002.
APA Liu Hui-Xue,Yang Xiao-Da,&Wang Kui.(2006).Effects of lanthanide ions (La3+, Gd3+, Yb3+) on production of reactive oxygen species in mitochondria.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,27(6),999-1002.
MLA Liu Hui-Xue,et al."Effects of lanthanide ions (La3+, Gd3+, Yb3+) on production of reactive oxygen species in mitochondria".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 27.6(2006):999-1002.
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