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学科主题基础医学
Kirenol, a compound from Herba Siegesbeckiae, induces apoptosis in human chronic myeloid leukemia K562 cells
Lu, Yue1; Qian, Ruiqin1; Xiao, Juan2; Xu, Dong2; Fu, Hongzheng3; Chen, Yingyu2
刊名PHARMAZIE
2014-02-01
DOI10.1691/ph.2014.3560
69期:2页:148-153
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]CYCLIN-DEPENDENT KINASES ; BCL-2 FAMILY PROTEINS ; CYTOCHROME-C ; P53 ; P21 ; MITOCHONDRIA ; INHIBITION ; MECHANISMS ; RELEASE ; CANCER
英文摘要

Kirenol is a biologically active substance isolated from Herba Siegesbeckiae. In the experiments, we explored a novel antitumor activity of kirenol. The data demonstrated that kirenol had strong cytotoxic effects to human chronic myeloid leukemia K562 cells, the 50% inhibitory concentration (IC50) for kirenol was 53.05 mu g/ml,18.19 mu g/ml and 15.08 mu g/ml for 24, 48 and 72 h, determined using the MU assay. Further studies showed that kirenol treatment caused externalization of phosphatidylserine, accumulation of ROS (reactive oxygen species), alteration of mitochondrial membrane potential, release of cytochrome c, reduction in the level of the Bcl-2 protein and upregulation of Bax and tBid, kirenol induced cell apoptosis in a caspase-independent manner. Further studies indicated that kirenol treatment triggered the arrest of cell cycle S period which might resulted from the up-regulation of phosphorylation of p53 (Ser 6 and Ser 37) and expression of p21 protein. Our results indicated that kirenol possesses antitumor action on human chronic myeloid leukemia K562 cells in vitro. Kirenol may have therapeutic potential for the treatment of cancer that deserves further investigation.

语种英语
WOS记录号WOS:000334261000013
项目编号2011CB910103 ; 2012ZX09101 ; 7072043
资助机构National Key Project for Basic Research of China (973) ; National Key New Drug Creation Program of China ; Natural Science Foundation of Beijing, China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65789
专题北京大学基础医学院_免疫学系
北京大学基础医学院
北京大学药学院
北京大学护理学院_护理学院
作者单位1.Peking Univ, Dept Integrated Chinese Tradit Western Med, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Dept Immunol, Ctr Human Dis Genom, Beijing 100191, Peoples R China
3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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GB/T 7714
Lu, Yue,Qian, Ruiqin,Xiao, Juan,et al. Kirenol, a compound from Herba Siegesbeckiae, induces apoptosis in human chronic myeloid leukemia K562 cells[J]. PHARMAZIE,2014,69(2):148-153.
APA Lu, Yue,Qian, Ruiqin,Xiao, Juan,Xu, Dong,Fu, Hongzheng,&Chen, Yingyu.(2014).Kirenol, a compound from Herba Siegesbeckiae, induces apoptosis in human chronic myeloid leukemia K562 cells.PHARMAZIE,69(2),148-153.
MLA Lu, Yue,et al."Kirenol, a compound from Herba Siegesbeckiae, induces apoptosis in human chronic myeloid leukemia K562 cells".PHARMAZIE 69.2(2014):148-153.
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