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学科主题: 临床医学
题名:
Human Tracheal Allotransplant With Greater Omentum for Revascularization
作者: Xu, Lin; Zhang, Shijie; Li, Jian; Liu, Jingwei; Liu, Haibo; Huang, Weiming; Shang, Xueqian
关键词: Cancer ; Immunosuppression ; Reconstruction ; Surgery ; Trachea ; Bronchoscopy
刊名: EXPERIMENTAL AND CLINICAL TRANSPLANTATION
发表日期: 2014-10-01
DOI: 10.6002/ect.2013.0250
卷: 12, 期:5, 页:448-453
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Transplantation
研究领域[WOS]: Transplantation
关键词[WOS]: TRANSPLANTATION ; ALLOGRAFT ; RESECTION ; STENOSIS ; CANCER
英文摘要:

Objectives: Human tracheal allotransplant is an option for treating long-segment tracheal defects, but no reliable and satisfactory tracheal transplant procedure has been developed. The purpose of this study is to review the results of 2-stage tracheal reconstruction in human tracheal allotransplant for tracheal defects > 5 cm with the use of greater omentum for revascularization.

Materials and Methods: There were 3 patients who had tracheal allograft. In stage 1, a segment of donor trachea (6 cm) was excised and wrapped in the recipient greater omentum. In stage 2, at 3 to 5 weeks after stage 1, the tracheal allograft and omental pedicle were orthotopically transplanted to the cervical part of the trachea. All patients received immunosuppression with tacrolimus, mycophenolate mofetil, and methylprednisolone. Fiberoptic bronchoscopy was performed monthly during the 6 months after stage 2.

Results: In all 3 patients, no major postoperative complication was observed. Transverse section of the donor trachea showed a mechanically stable chondral framework. Histologic sections stained with hematoxylin-eosin showed complete cartilage rings covered by intact respiratory epithelium.

Conclusions: A 2-stage procedure for human tracheal transplant with greater omentum is a safe and effective technique for tracheal reconstruction.

语种: 英语
WOS记录号: WOS:000358450600010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65801
Appears in Collections:北京大学第一临床医学院_胸外科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Thorac Surg, Beijing 100034, Peoples R China

Recommended Citation:
Xu, Lin,Zhang, Shijie,Li, Jian,et al. Human Tracheal Allotransplant With Greater Omentum for Revascularization[J]. EXPERIMENTAL AND CLINICAL TRANSPLANTATION,2014,12(5):448-453.
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