IR@PKUHSC  > 北京大学第一临床医学院  > 胸外科
学科主题临床医学
Human Tracheal Allotransplant With Greater Omentum for Revascularization
Xu, Lin; Zhang, Shijie; Li, Jian; Liu, Jingwei; Liu, Haibo; Huang, Weiming; Shang, Xueqian
关键词Cancer Immunosuppression Reconstruction Surgery Trachea Bronchoscopy
刊名EXPERIMENTAL AND CLINICAL TRANSPLANTATION
2014-10-01
DOI10.6002/ect.2013.0250
12期:5页:448-453
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation
研究领域[WOS]Transplantation
关键词[WOS]TRANSPLANTATION ; ALLOGRAFT ; RESECTION ; STENOSIS ; CANCER
英文摘要

Objectives: Human tracheal allotransplant is an option for treating long-segment tracheal defects, but no reliable and satisfactory tracheal transplant procedure has been developed. The purpose of this study is to review the results of 2-stage tracheal reconstruction in human tracheal allotransplant for tracheal defects > 5 cm with the use of greater omentum for revascularization.

Materials and Methods: There were 3 patients who had tracheal allograft. In stage 1, a segment of donor trachea (6 cm) was excised and wrapped in the recipient greater omentum. In stage 2, at 3 to 5 weeks after stage 1, the tracheal allograft and omental pedicle were orthotopically transplanted to the cervical part of the trachea. All patients received immunosuppression with tacrolimus, mycophenolate mofetil, and methylprednisolone. Fiberoptic bronchoscopy was performed monthly during the 6 months after stage 2.

Results: In all 3 patients, no major postoperative complication was observed. Transverse section of the donor trachea showed a mechanically stable chondral framework. Histologic sections stained with hematoxylin-eosin showed complete cartilage rings covered by intact respiratory epithelium.

Conclusions: A 2-stage procedure for human tracheal transplant with greater omentum is a safe and effective technique for tracheal reconstruction.

语种英语
WOS记录号WOS:000358450600010
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/65801
专题北京大学第一临床医学院_胸外科
作者单位Peking Univ, Hosp 1, Dept Thorac Surg, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Xu, Lin,Zhang, Shijie,Li, Jian,et al. Human Tracheal Allotransplant With Greater Omentum for Revascularization[J]. EXPERIMENTAL AND CLINICAL TRANSPLANTATION,2014,12(5):448-453.
APA Xu, Lin.,Zhang, Shijie.,Li, Jian.,Liu, Jingwei.,Liu, Haibo.,...&Shang, Xueqian.(2014).Human Tracheal Allotransplant With Greater Omentum for Revascularization.EXPERIMENTAL AND CLINICAL TRANSPLANTATION,12(5),448-453.
MLA Xu, Lin,et al."Human Tracheal Allotransplant With Greater Omentum for Revascularization".EXPERIMENTAL AND CLINICAL TRANSPLANTATION 12.5(2014):448-453.
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