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学科主题: 基础医学
题名:
Effects of TFAR19 gene on the in vivo biorheological properties and pathogenicity of mouse erythroleukemia cell line MEL
作者: Gu Li; Tang ZhiYu; He DongQi; Ka WeiBo; Sun DaGong; Wen ZongYao
关键词: TFAR19 gene ; erythroleukemia cell line MEL ; biorheological property
刊名: SCIENCE IN CHINA SERIES C-LIFE SCIENCES
发表日期: 2007-02-01
DOI: 10.1007/s11427-007-0007-3
卷: 50, 期:1, 页:111-119
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics
关键词[WOS]: BIOPHYSICAL PROPERTIES ; LOW-VISCOSITY ; RBC MEMBRANE ; LEUKEMIA ; MICE ; RECEPTORS ; DISEASE ; JURKAT ; TRAIL ; DEATH
英文摘要:

After injecting VP16, MEL cells and MEL-TF19 cells into the body of mice, with those injected with the same dose of saline as the control group, we observed the mice for their blood pictures, histological changes of the liver and spleen, and the hemorhelogical indexes within 4 weeks. The results indicated that after injecting MEL cells, the mice entered into a pathological status similar to erythroleukemia, which had the following exhibitions: the tissue structures of the liver and spleen were damaged, a mass of proerythroblasts, basophil erythroblasts and polychromatophilic erythroblasts could be observed on the smears of the bone marrow and spleen, and the deformability and orientation ability of erythrocytes were both depressed. The pathogenicity of MEL-TF19 cells carrying TFAR19 gene was obviously lower than that of MEL cells, and the MEL-TF19 cells even lost their faintish pathogenicity under the apoptosis-inducing effect of the chemotherapeutic reagent. The outcome from the animal experiments suggests that the TFAR19 gene suppresses the pathogenicity of MEL cells to the mice, and the effect may be better exerted with the synergy of the chemotherapeutic reagent.

语种: 英语
WOS记录号: WOS:000245146700016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/65810
Appears in Collections:基础医学院_北京大学血液流变中心_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Hemorheol Ctr, Dept Med Phys,Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Shandong Univ, Life Sch, State Key Lab Microbial Technol, Jinan 250100, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Appl Sci, Beijing 100083, Peoples R China

Recommended Citation:
Gu Li,Tang ZhiYu,He DongQi,et al. Effects of TFAR19 gene on the in vivo biorheological properties and pathogenicity of mouse erythroleukemia cell line MEL[J]. SCIENCE IN CHINA SERIES C-LIFE SCIENCES,2007,50(1):111-119.
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